Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Dgp/iga Results Positive

patz

Recommended Posts

patz Newbie
patz
Posted

Hi all, I just recvd panel back. All neg except the new GDP IGA came back 38. GDP IGG was neg. Doc wants me to see GI. With only one positive test but supposedly quite accurate can I assume celiac disease? I have bloating, gas, nausea and sometimes just don't feel well.

Mainly need to know if worth getting scoped on only one positive test. Help!!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Wolicki Enthusiast
Wolicki
Posted

This is actually the first I have heard of this test. After reading this study:

Open Original Shared Link

I think that a biopsy is wise. It appears to be a very reliable indicator. Good luck!

  • 1 year later...
gfcolorado Newbie
gfcolorado
Posted

Hi all, I just recvd panel back. All neg except the new GDP IGA came back 38. GDP IGG was neg. Doc wants me to see GI. With only one positive test but supposedly quite accurate can I assume celiac disease? I have bloating, gas, nausea and sometimes just don't feel well.

Mainly need to know if worth getting scoped on only one positive test. Help!!

I just came across your post and realize it's been awhile so I'm not sure if you'll get this. I just had a positive only GDP biopsy and was wondering what your biopsy came back. Thanks!

Emsstacey Rookie
Emsstacey
Posted

gfcolorado, are you saying that only your deamidated gliadin was positive and your biopsy was positive, too?

I ask because my only antibody that came back positive was the deamidated gliadin at a 31. I did not get the scope because I had one done about 10 years ago looking for the same thing. I never did get the results, though, just told it was ok. I'm actually going to go pick them up this week to see for myself what they say.

Just curious! Thanks!

melissa222 Newbie
melissa222
Posted

I just got my results back I had deamidated gliadin antibodies at 36, along with a DQ8 gene (I got the genetic test at the same time). Other tests were negative. I have major celiac symptoms. I'm having the scope done next week. My GI Dr, who was recommended to me by a local celiac support group, said this test was a very strong indication that I do have celiac. From what I've read this test is very specific to celiac, and a valuable new test in detecting celiac in patients, like me, who have tested negative with the other tests.

Emsstacey Rookie
Emsstacey
Posted

Wow. It sounds like a lot more people with only the positive DGP. I guess that I need to go retest and find a GI. I would be very grateful if you update after your scope!

Skylark Collaborator
Skylark
Posted

DGP is considerably more sensitive than the other tests in the celiac panel.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


melissa222 Newbie
melissa222
Posted

My biopsy came back normal. Dr says it is not celiac but to try gluten free diet. I'm bummed because I thought I had hope to feel better.

ravenwoodglass Mentor
ravenwoodglass
Posted

My biopsy came back normal. Dr says it is not celiac but to try gluten free diet. I'm bummed because I thought I had hope to feel better.

Don't be bummed get on the diet. If your DGP was positive you do need to avoid all gluten. False negative biopsies are very common. Get on the diet strictly and you should be feeling better soon.

Skylark Collaborator
Skylark
Posted

My biopsy came back normal. Dr says it is not celiac but to try gluten free diet. I'm bummed because I thought I had hope to feel better.

You do have hope to feel better. My mom came back negative on antibodies and biopsy. She feels a heck of a lot better off gluten. With the DGP there is certainly something going on and you might be pleasantly surprised.

pain*in*my*gut Apprentice
pain*in*my*gut
Posted

My biopsy came back normal. Dr says it is not celiac but to try gluten free diet. I'm bummed because I thought I had hope to feel better.

My biopsy was normal, too. My GI doc dismissed me without any follow up to discuss my obvious Celiac symptoms. According to him (and a lot of docs), if the biopsy was negative, I don't have a problem. What an idiot. :angry:

When my rheumatologist took one look at my DGP levels, he said it was most certainly Celiac and to avoid gluten like the plague. :o DGP is very specific for Celiac, so in his opinion, it trumps the biopsy because of the false negative probability if the damage is patchy in the intestines.

I am now one month gluten free, and my stomach issues are 80% better than before! I think you will be pleasanly suprised by how good you will feel off of gluten! B)

gfcolorado Newbie
gfcolorado
Posted

gfcolorado, are you saying that only your deamidated gliadin was positive and your biopsy was positive, too?

I ask because my only antibody that came back positive was the deamidated gliadin at a 31. I did not get the scope because I had one done about 10 years ago looking for the same thing. I never did get the results, though, just told it was ok. I'm actually going to go pick them up this week to see for myself what they say.

Just curious! Thanks!

When I was originally tested 3 years ago, all my tests (TTG, EMA, DGP) were positive and so was my biopsy. This time, only my DGP was positive. My TTG and EMA were negative. I think I'm going to get another endoscopy just to see what's going on. If I do, I'll let you know.

gfcolorado Newbie
gfcolorado
Posted

My biopsy was normal, too. My GI doc dismissed me without any follow up to discuss my obvious Celiac symptoms. According to him (and a lot of docs), if the biopsy was negative, I don't have a problem. What an idiot. :angry:

When my rheumatologist took one look at my DGP levels, he said it was most certainly Celiac and to avoid gluten like the plague. :o DGP is very specific for Celiac, so in his opinion, it trumps the biopsy because of the false negative probability if the damage is patchy in the intestines.

I am now one month gluten free, and my stomach issues are 80% better than before! I think you will be pleasanly suprised by how good you will feel off of gluten! B)

I think there is so much they still don't know about Celiac and Gluten Sensitivity and the DGP test. When I went to a Celiac conference about 3 years ago, they hardly talked about Gluten sensitivity. When I went last year, the top Celiac researchers all talked about it. Most doctors say that you don't have Celiac until your biopsy is positive and no one really knows at what point you become positive. I had really bad stomach aches my whole life but wasn't diagnosed with Celiac until I was 43. My biopsy was positive and my stomach aches are gone but would I have tested positive when I was a kid or 10 years prior? I don't know but going off of gluten would have made my stomach aches go away and might have prevented villous atrophy and other auto immune diseases.

Thanks everyone for sharing your info!

  • 2 weeks later...
melissa222 Newbie
melissa222
Posted

Yall were right! After about 11 days gluten free my energy levels picked up and I have felt incredible...more energy, anxiety is gone, more focus...I have not felt this good in years. Now I'm going to patiently wait for my physical problems to improve! It's almost miraculous. To think had I not figured this out on my own, I would've lived out the rest of my life completely miserable. Doctors are grossly mis/uneducated about this!! All the time n money spent on Dr visits and tests, when the whole time it was food. :/ I consider myself lucky. So many suffer so much longer and never know how poisonous gluten can be. It should come with a warning label!

Skylark Collaborator
Skylark
Posted

That's wonderful news! I'm so glad to hear you're feeling better. Thanks a lot for coming back to update us and share your good news!

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. trents
      - trents replied to JudyLou's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      1

      Seeking advice on potential gluten challenge

      Welcome to the celiac.com community, @JudyLou! There are a couple of things you might consider to help you in your decision that would not require you to do a gluten challenge. The first, that is if you have not had this test run already, is to request a "total IGA" test to be run. One of the reasons that celiac blood antibody tests can be negative...
    2. JudyLou
      - JudyLou posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      1

      Seeking advice on potential gluten challenge

      Hi there, I’m debating whether to consider a gluten challenge and I’m hoping someone here can help with that decision (so far, none of the doctors have been helpful). I have a history of breaking out in a horrible, burning/itchy somewhat blistering rash about every 8 years. This started when I was in my early 30’s and at that point it started at the ankle...
    3. marzian
      - marzian commented on Scott Adams's article in Diagnosis, Testing & Treatment
      5

      A Future Beyond the Gluten-Free Diet? Scientists Test a New Cell Therapy for Celiac Disease (+Video)

      This is very exciting news. The research lends itself to preventing the immune system in other autoimmune disorders from getting out of sorts. As someone with a compendium of autoimmune disorders I feel a bit of hope.
    4. Jmartes71
      - Jmartes71 posted a topic in Related Issues & Disorders
      0

      Medications

      Hello, just popped in my head to ask this question about medications and celiac? I have always had refurse reaction to meds since I can remember of what little meds my body is able to tolerate. I was taking gabapentin 300mg for a week, in past I believe 150? Any ways it amps me up not able to sleep, though very tired.However I did notice it helped with...
    5. Scott Adams
      - Scott Adams replied to GlutenFreeChef's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      11

      Blood Test for Celiac wheat type matters?

      I'm not saying that some celiacs won't need it, but it should be done under a doctor's supervision because it can cause lots of problems in some people.
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      133,139
    • Most Online (within 30 mins)
      7,748
    kathleen apodaca
    Newest Member
    kathleen apodaca
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Who's Online (See full list)

    • There are no registered users currently online

  • Upcoming Events

  • Posts

    • trents
      Seeking advice on potential gluten challenge

      By trents · Posted

      Welcome to the celiac.com community, @JudyLou! There are a couple of things you might consider to help you in your decision that would not require you to do a gluten challenge. The first, that is if you have not had this test run already, is to request a "total IGA" test to be run. One of the reasons that celiac blood antibody tests can be negative, apart from not having celiac disease, that is, is because of IGA deficiency. If a person is IGA deficient, they will not respond accurately to the celiac disease blood antibody tests (such as the commonly run TTG-IGA). The total IGA test is designed to check for IGA deficiency. The total IGA test is not a celiac antibody test so I wouldn't think that a gluten challenge is necessary. The second is to have genetic testing done to determine if you have the genetic potential to develop celiac disease. About 30-40% of  the general population have the genetic potential but only about 1% actually develop celiac disease. So, genetic testing cannot be used to diagnose celiac disease but it can be used to rule it out. Those who don't have the genetic potential but still have reaction to gluten would not be diagnosed with celiac disease but with NCGS (Non Celiac Gluten Sensitivity).  Another possibility is that you do have celiac disease but are in remission. We do see this but often it doesn't last.
    • JudyLou
      Seeking advice on potential gluten challenge

      By JudyLou · Posted

      Hi there, I’m debating whether to consider a gluten challenge and I’m hoping someone here can help with that decision (so far, none of the doctors have been helpful). I have a history of breaking out in a horrible, burning/itchy somewhat blistering rash about every 8 years. This started when I was in my early 30’s and at that point it started at the ankles and went about to my knees. Every time I had the rash it would cover more of my body, so my arms and part of my torso were impacted as well, and it was always symmetrical. First I was told it was an allergic reaction to a bug bite. Next I was told it was eczema (after a biopsy of the lesion - not the skin near the lesion) and given a steroid injection (didn’t help). I took myself off of gluten about 3 weeks before seeing an allergist, just to see if it would help (it didn’t in that time period). He thought the rash looked like dermatitis herpetiformis and told me to eat some bread the night before my blood tests, which I did, and the tests came back negative. I’ve since learned from this forum that I needed to be eating gluten daily for at least a month in order to get an accurate test result. I’m grateful to the allergist as he found that 5 mg of doxepin daily will eliminate the rash within about 10 days (previously it lasted for months whether I was eating gluten or not). I have been gluten free for about 25 years as a precaution and recommendation from my doctor, and the pattern of breaking out every 8 years or so remains the same except once I broke out after just one year (was not glutened as far as I know), and now it’s been over 9 years. What’s confusing to me, is that there have been 3 times in the past 2 years when I’ve accidentally eaten gluten, and I haven’t had any reaction at all. Once someone made pancakes (they said they were gluten-free, they were not) and I ate several. I need to decide whether to do a gluten challenge and get another blood test. If I do, are these tests really accurate? I’m also concerned that I could damage my gut in that process if I do have celiac disease. My brother and cousin both had lymphoma so that’s a concern regarding a challenge as well, though there is a lot of cancer in various forms in my family so there may be no gluten connection there. Sorry for the ramble, I’m just doubting the need to remain gluten free if I don’t have any reaction to eating it and haven’t had a positive test (other than testing positive for one of the genes, though it sounds like that’s pretty common). I’d appreciate any thoughts or advice! 
    • Jmartes71
      Medications

      By Jmartes71 · Posted

      Hello, just popped in my head to ask this question about medications and celiac? I have always had refurse reaction to meds since I can remember  of what little meds my body is able to tolerate. I was taking gabapentin 300mg for a week,  in past I believe 150? Any ways it amps me up not able to sleep, though very tired.However I did notice it helped with my bloating sibo belly.I hate that my body is that sensitive and medical doesn't seem to take seriously. Im STILL healing with my skin, eye, and now ms or meningioma ( will know in April  which)and dealing with this limbo nightmare. I did write my name, address ect on the reclamation but im not tech savvy and not sure if went through properly. I called my city representative in Stanislaus County and asked if theres a physical paper i can sign for proclamation for celiac and she had no clue about what I was saying, so I just said I'll go back on website. 
    • Scott Adams
      Blood Test for Celiac wheat type matters?

      By Scott Adams · Posted

      I'm not saying that some celiacs won't need it, but it should be done under a doctor's supervision because it can cause lots of problems in some people.
    • Jmartes71
      Airborne Gluten?

      By Jmartes71 · Posted

      I also noticed I get debilitating migraines when I smell gluten, wheat and its not taken seriously when it affects one in every way.Im still begging to properly be heard.I also noticed tolerance level is down the drain with age and life changes. I have been told by incompetent medical that im not celiac or that sensitive. Diagnosed in 1994 by gi biopsy gluten-free ever since along with other lovely food allergies. Prayers
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.