Jump to content
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Odds, My Father Has Celiac, What Are Chances My Future Kid Gets It?


KP44

Recommended Posts

KP44 Newbie

My dad has celiac, I am currently in my 20s and do not have it, or any signs of it. I was just wondering for me and my future spouse, what the chances are if any that my son or daughter will have celiac?


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



sa1937 Community Regular

Welcome to the forum! If your father has celiac, your risk and your future children's risk is definitely greater. Check out these Open Original Shared Link from the U of Chicago Celiac Disease Center.

KP44 Newbie

I do not have celiac though thankfully, I was just wondering about the chances of my future kids having it.

lilu Rookie

Dear KP,

I am very happy for you that you don't currently have the disease. May I ask, did you do genetic testing? If you had the genetic tests and know whether or not you carry your father's celiac gene, you can then have a better idea of your future risk and also potential risk for your future children (at least with respect to your contribution! :D )

For instance, even though I don't have my gene test back yet, we got my husbands results, and he is DQ2/DQ2, the strongest genetic profile for the disease. We have 2 daughters, and all the poor guy had available to give were DQ2s, so that means, independent of my genetic results, I already know that both girls carry at least 1 high risk gene.

If you get genetic testing done (assuming you haven't already) you will also find out whether or not you are at increased risk for developing the disease at some point in life, and can make personal lifestyle choices in an informed manner, such as regular screening, etc.

We decided after receiving my husband's results to begin living gluten free even though his antibody tests were all normal, because of his elevated risk, his strong family history of gastric cancers, related autoimmune diseases, and his own pretty severe symptoms.

He is feeling amazing symptom relief and we figured, better an ounce of prevention now than a pound of cure later.

Take care of yourself!

sa1937 Community Regular

I do not have celiac though thankfully, I was just wondering about the chances of my future kids having it.

Thankfully you don't have it! Although if I had to choose a disease, this is a pretty good one to have.

Since your father has it, it definitely increases your chance of getting it some time in your lifetime...like a 1 in 22 chance. I think my late mother had it (undiagnosed), I have it and my adult daughter was diagnosed in Aug., 2010.

KP44 Newbie

I haven't had any genetic test, and I am 24 with no signs. I would probably be interested at some point in getting a genetic test, for I can see if I carry..which I probably do, then I'll have to pull out my highschool biology skills with punnet squares lol

melikamaui Explorer

I haven't had any genetic test, and I am 24 with no signs. I would probably be interested at some point in getting a genetic test, for I can see if I carry..which I probably do, then I'll have to pull out my highschool biology skills with punnet squares lol

Unfortunately just because you don't have symptoms doesn't mean you don't have celiac disease. Some people are "silent celiacs", totally asymptomatic. Also there are over 300 symptoms of celiac disease, so you just never know. You may want to at least have a genetic test to find out for sure.


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



KP44 Newbie

Well lets say I dont have it like I assume..what are the odds of my kid having it?

kareng Grand Master

If you received the gene from a parent, you can pass it to a child. These are genes you can have but, unless they " activate", you can be disease free.

lovegrov Collaborator

All the experts say that ALL first-degree relatives of somebody with celiac should have the blood test for the disease. Whether you have symptoms or not.

richard

Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      131,902
    • Most Online (within 30 mins)
      7,748

    Patty6133
    Newest Member
    Patty6133
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • Xravith
      Yes, you are right. Indeed, I’ve been feeling anemic since the beginning of this week, and today I felt horrible during a lecture at the university, I was trembling a lot and felt all my body incredibly heavy, so I had to come back home. I’ll do a blood test tomorrow, but I’m just worried about the possibility of it coming back negative. I’ve been eating two cookies in the morning as my only source of gluten over the past two weeks—could that affect the final result?
    • trents
      Welcome to the forum, @Judy M! Yes, he definitely needs to continue eating gluten until the day of the endoscopy. Not sure why the GI doc advised otherwise but it was a bum steer.  Celiac disease has a genetic component but also an "epigenetic" component. Let me explain. There are two main genes that have been identified as providing the "potential" to develop "active" celiac disease. We know them as HLA-DQ 2.5 (aka, HLA-DQ 2) and HLA-DQ8. Without one or both of these genes it is highly unlikely that a person will develop celiac disease at some point in their life. About 40% of the general population carry one or both of these two genes but only about 1% of the population develops active celiac disease. Thus, possessing the genetic potential for celiac disease is far less than deterministic. Most who have the potential never develop the disease. In order for the potential to develop celiac disease to turn into active celiac disease, some triggering stress event or events must "turn on" the latent genes. This triggering stress event can be a viral infection, some other medical event, or even prolonged psychological/emotional trauma. This part of the equation is difficult to quantify but this is the epigenetic dimension of the disease. Epigenetics has to do with the influence that environmental factors and things not coded into the DNA itself have to do in "turning on" susceptible genes. And this is why celiac disease can develop at any stage of life. Celiac disease is an autoimmune condition (not a food allergy) that causes inflammation in the lining of the small bowel. The ingestion of gluten causes the body to attack the cells of this lining which, over time, damages and destroys them, impairing the body's ability to absorb nutrients since this is the part of the intestinal track responsible for nutrient absorption and also causing numerous other food sensitivities such as dairy/lactose intolerance. There is another gluten-related disorder known as NCGS (Non Celiac Gluten Sensitivity or just, "gluten sensitivity") that is not autoimmune in nature and which does not damage the small bowel lining. However, NCGS shares many of the same symptoms with celiac disease such as gas, bloating, and diarrhea. It is also much more common than celiac disease. There is no test for NCGS so, because they share common symptoms, celiac disease must first be ruled out through formal testing for celiac disease. This is where your husband is right now. It should also be said that some experts believe NCGS can transition into celiac disease. I hope this helps.
    • Judy M
      My husband has had lactose intolerance for his entire life (he's 68 yo).  So, he's used to gastro issues. But for the past year he's been experiencing bouts of diarrhea that last for hours.  He finally went to his gastroenterologist ... several blood tests ruled out other maladies, but his celiac results are suspect.  He is scheduled for an endoscopy and colonoscopy in 2 weeks.  He was told to eat "gluten free" until the tests!!!  I, and he know nothing about this "diet" much less how to navigate his in daily life!! The more I read, the more my head is spinning.  So I guess I have 2 questions.  First, I read on this website that prior to testing, eat gluten so as not to compromise the testing!  Is that true? His primary care doctor told him to eat gluten free prior to testing!  I'm so confused.  Second, I read that celiac disease is genetic or caused by other ways such as surgery.  No family history but Gall bladder removal 7 years ago, maybe?  But how in God's name does something like this crop up and now is so awful he can't go a day without worrying.  He still works in Manhattan and considers himself lucky if he gets there without incident!  Advice from those who know would be appreciated!!!!!!!!!!!!
    • Scott Adams
      You've done an excellent job of meticulously tracking the rash's unpredictable behavior, from its symmetrical spread and stubborn scabbing to the potential triggers you've identified, like the asthma medication and dietary changes. It's particularly telling that the rash seems to flare with wheat consumption, even though your initial blood test was negative—as you've noted, being off wheat before a test can sometimes lead to a false negative, and your description of the other symptoms—joint pain, brain fog, stomach issues—is very compelling. The symmetry of the rash is a crucial detail that often points toward an internal cause, such as an autoimmune response or a systemic reaction, rather than just an external irritant like a plant or mites. I hope your doctor tomorrow takes the time to listen carefully to all of this evidence you've gathered and works with you to find some real answers and effective relief. Don't be discouraged if the rash fluctuates; your detailed history is the most valuable tool you have for getting an accurate diagnosis.
    • Scott Adams
      In this case the beer is excellent, but for those who are super sensitive it is likely better to go the full gluten-free beer route. Lakefront Brewery (another sponsor!) has good gluten-free beer made without any gluten ingredients.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.