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Gi Appointment Today

bobtom

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bobtom Rookie
bobtom
Posted

An update from last week. My 11 year old son, complaining of stomach aches for several months, to most of the year went to pediatrition last week. The only celiac test she did was Gliadin IGA antibody (deamidated peptide) with the result of 67 (<20). Got in to see GI today and he said this test is not reliable unless it is drawn with the tissue transglutiminase AB IGA and total IGA, which he will have drawn in a couple of days. So my question is, do you see many negative tTg levels with a positive gliadin IGA? and if the tTg is negative, can we pretty much rule out the celiac? I am assuming his total IGA will be within normal range since he had and elevated gliadin IGA to begin with. Any thoughts?? The GI was not very forthcoming. Thanks!!

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gatita Enthusiast
gatita
Posted

I'm anxious to hear what others say about this!

I had highly positive anti-gliadin iga but slightly negative ttg ab. This was after almost 4 weeks gluten-free, however, so me and my doc assumed that was why the negative ttg. He is satisfied to call it celiac anyway (for a long list of other reasons).

ps. Oh, but my overall IGA was also tested and normal, which gives the anti-gliadin iga test more value.

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    • trents
      Test interpretations

      By trents · Posted

      Possibly. Your total IGA (Immunoglobulin A, Qn, Serum) is actually high so you are not IGA deficient. In the absence of IGA deficiency, the most reliable celiac antibody test would be the t-Transglutaminase (tTG) IgA for which your score is within normal range. There are other things besides celiac disease that might cause an elevated DGP-IGA (Deamidated Gliadin Abs, lgA) for which you do have a positive score. It might also be of concern that your total IGA is elevated as that can indicate some other health problems, some of which are serious.  Had you been practicing a gluten free or a reduced gluten free diet prior to the blood draw? Talk to your physician about these things. I would also seek an endoscopy/biopsy of the small bowel to check for damage to the villous lining, which is the gold standard diagnostic test for celiac disease.
    • MicG
      Test interpretations

      By MicG · Posted

      Test results as follows: Deamidated Gliadin Abs, lgA 40 H (normal range 0-19) Deamidated Gliadin Abs, IgG 4 (0-19) t-Transglutaminase (tTG) IgA <2 (0-3) t-Transglutaminase (tTG) IgG <2 (0-5) Endomysial Antibody IgA Negative (Negative) Immunoglobulin A, Qn, Serum 535 H (87-352) Do I have celiac?
    • catnapt
      how long does it take for the genetic blood test for celiac to come back?

      By catnapt · Posted

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    • Scott Adams
      Second chance

      By Scott Adams · Posted

      I'm not sure why "colonoscopy" keeps coming up for you, again it would be an endoscopy to diagnose celiac disease, but it seems that Kaiser should still have your records. If you were diagnosed by them in the 1990's using a blood test and endoscopy, then you definitely have celiac disease, and hopefully you've been gluten-free since that time. You should be able to contact Kaiser for those records.
    • Russ H
      Concerning GP advice

      By Russ H · Posted

      This sounds like a GP who is ignorant regarding coeliac disease. The risk with consuming gluten for several days is that it triggers the coeliac immune response, leading to raised auto-antibodies and active disease for several months. People may not even be aware of symptoms during this process, but it is causing damage to the body. As trents has said, the gut lining normally recovers on a strict gluten-free diet, and this happens much faster in children than in adults.
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