Help With Lab Result Interpretation

[cwredden]

Morning All,

While using my limited Google-Fu skills to find a way of deciphering the results of my Enterolab stool testing, I saw several results pointing me to this forum. While I consider myself a reasonable intelligent person, this seems sort of Greek to me so, I thought I'd try to ask someone who might be more of a 'subject matter expert'. If I'm reading this correctly, I do not really have Celiac disease but, I do have sensitivity to both gluten and eggs (the later completely threw me for a loop!) - am I correct in my understanding?

I also don't know if I really understand the genetic results but, again, sounds like I do not have the genes for Celiac but, do have two genes which indicate a predisposition to gluten sensitivity, does that sound right? Any input or guidance would be greatly appreciated. I'd like to be able to explain this to my other half who's pretty much said he won't be changing the way he cooks, with regard to the elimination of gluten, until I can show him there's a legitimate reason why he should (e.g., results showing that I have a sensitivity to wheat products).

Thanks in advance for your time and information!

Best,

C.

Edit - Realized I never included the actual results....

Gluten/Antigenic Food Sensitivity Stool/Gene Panel

Fecal Anti-gliadin IgA 13 Units (Normal Range is less than 10 Units)

Fecal Anti-casein (cow’s milk) IgA 7 Units (Normal Range is less than 10 Units)

Fecal Anti-ovalbumin (chicken egg) IgA 13 Units (Normal Range is less than 10 Units)

Fecal Anti-soy IgA 4 Units (Normal Range is less than 10 Units)

HLA-DQB1 Molecular analysis, Allele 1 0301

HLA-DQB1 Molecular analysis, Allele 2 0609

Serologic equivalent: HLA-DQ 3,1 (Subtype 7,6)

I wasn't sure if the narrative bits were also important to include but if so, please let me know and I'll happily update the information.

[kareng]

Curious....why didn't you go to a doctor and get a blood test? from what I have seen with Enterolabs, everyone gets a positive result. .

I don't believe scientists have identified any genes for gluten sensitivity as that is a fairly new area of study.

Also read this link and the link T the bottom of it:

Open Original Shared Link

"Why don’t you recognize tests (stool tests or otherwise) for non-celiac gluten sensitivity that are currently available through companies like Enterolab or Cyrex?

We only embrace tests that have endured rigorous scientific evaluations. So far, these tests have received no evidence-based support.

Enterolab has never successfully published anything on the accuracy of stool tests (nor have any other stool test manufacturers, to our knowledge) making it difficult to confirm the research results. Because of this, we must make our decisions based on what has been published; Harvard, UCSD, and the American College of Gastroenterology all agree that stool tests are simply not sensitive or specific enough methods in screening for celiac disease.

Further reading: “Detection of secretory IgA antibodies against gliadin and human tissue transglutaminase in stool to screen for coeliac disease in children: validation study” at BMJ.com"

[cwredden]

Curious....why didn't you go to a doctor and get a blood test? from what I have seen with Enterolabs, everyone gets a positive result. .

Primarily because from searching around the internet, it sounded as though blood tests were not as reliable (a link from an article on this site) and in my mind it did seem reasonable that if there was an issue with something related to the antibodies in the digestive tract, it made more sense to look there before those made their way into the blood stream. In my case, I don't think the test showed a positive for Celiac, which I'm quite happy about. With regard to everyone getting a positive result from Enterolab, I think a reasonable answer might be that individuals who have symptoms which align with gluten intolerance/sensitivity are the ones requesting the test. Could there be false positives? Possible. From my readings, I've seen a lot of information about false negatives from blood tests as well.

If the results from the stool testing had indicated Celiac then my next step would have been to move to the blood testing and/or the biopsy testing.

[cwredden]

Updated....realized I didn't actually include the information from the test....

[nvsmom]

The only test you did that tests for celiac (as far as I can tell) is your anti-gliadin IgA whish is positive at 13. As you said, your next step is to try blood testing. The most common tests are:

ttg IgA and IgG

EMA IgA

total serum IgA

DGP IgA and IgG

I'm not sure how accurate the enterolab tests are (did not do them) but I have heard they tend to have a LOT of positives. The blood work done in your typical lab will err the other way: they have approximately a 25% false positive rate, but biopsies seem to catch those who appear to have normal blood.

I don't know anything about the DNA testing. I tested positive on blood work so I never bothered learning about the DNA tests since it's a moot point for me.

Good luck with your future testing if you choose to go tha direction. I hope you feel well soon.

[Ninja]

I do believe that the blood testing has a 25% false negative rate. There are very very few false positives on blood work. :-)

It looks like you have DQ7 and DQ6. Currently, DQ7 is not recognized as a celiac gene but there is some research starting to come out which points otherwise, especially in the case of no DQ2 or DQ8.

Laura