Jump to content
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Gene Result Question


ADevoto

Recommended Posts

ADevoto Explorer

I finally got our son's stool and gene test back from Enterolab. Here are the results. I have a question about the gene results - Does this mean he has multiply genes or just subtypes . It is very confusing.

Gluten sensitivity stool test - 13 units (shows sensitivity)

All other tests for normal

Gene test:

Molecular analysis - HLA-DQB1 *0201, 0602

Serologic analysuis: HLA-DQ 2, 1 (subtype 2,6)

It looks like he needs to be on the diet. Any comments? Thanks


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



3boyzmom Newbie

Within each set of genes there are many subtypes. The number *0201 is the exact gene your son has. Then withthin the grouping of *02xx genes there are subtypes. Same with any of the genes, so the *0602 is the DQ1, subtype 6.

The genes pan out as follows:

DQB1 *0201 = DQ2, subtype 2

DQB1 *0602 = DQ1, subtype 6 (OR it can also be referred to as DQ6)

He has 2 genes, one from you and one from your husband. BOTH of these genes predispose someone to a gluten sensitivity. DQ2 is associated with celiac disease and gastro problems, while DQ1 is associated with gluten induced neurological problems. I would definitely take a look at you and your husband and any other children.

There are some pretty good explanations on these genes and their typing on the Braintalk forum. Here is one post that gives some links to help understand your gene naming:

Open Original Shared Link

ADevoto Explorer

Thank you , thank you, thank you. I thought no one was ever going to reply!! That was very helpful. and actually cleared up somethings. It was very interesting that you said that that the DQ1 (I think) was tied to nuerological problems because he has many of these that we haven't been able to figure out why. Thank you so much!

burdee Enthusiast

Hi ADevoto: Enterolab usually adds an interpretation of test results with their lab test results email. What did they say about the genetic results? If you have questions, write to Dr. Fine at E-lab. He WILL answer your email promptly. ;)

BURDEE

ADevoto Explorer

They just said that the HLA - DQ2 is the main gene that predisposes to gluten sensitivity and celiac. Can also prodisse to microscopic colitis and other autoimmune syndromes. Nothing about DQ1. But Dr. Fine did return an email to me that just said the above and that DQ1 usually doesn't lead to celiac but to sensitivity only.

I just wanted to understand more. I know that there is high % of people that are celiac that have the DQ2 gene but I really need to find the statistic that show what % of people that have the gene actually become celiac. Need more "proof" for my husband.

Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      131,667
    • Most Online (within 30 mins)
      7,748

    AubreyMBSMartin
    Newest Member
    AubreyMBSMartin
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • Inkie
      Thank you for the information ill will definitely bring it into practice .
    • Scott Adams
      While plain, pure tea leaves (black, green, or white) are naturally gluten-free, the issue often lies not with the tea itself but with other ingredients or processing. Many flavored teas use barley malt or other gluten-containing grains as a flavoring agent, which would be clearly listed on the ingredient label. Cross-contamination is another possibility, either in the facility where the tea is processed or, surprisingly, from the tea bag material itself—some tea bags are sealed with a wheat-based glue. Furthermore, it's important to consider that your reaction could be to other substances in tea, such as high levels of tannins, which can be hard on the stomach, or to natural histamines or other compounds that can cause a non-celiac immune response. The best way to investigate is to carefully read labels for hidden ingredients, try switching to a certified gluten-free tea brand that uses whole leaf or pyramid-style bags, and see if the reaction persists.
    • Scott Adams
      This is a challenging and confusing situation. The combination of a positive EMA—which is a highly specific marker rarely yielding false positives—alongside strongly elevated TTG on two separate occasions, years apart, is profoundly suggestive of celiac disease, even in the absence of biopsy damage. This pattern strongly aligns with what is known as "potential celiac disease," where the immune system is clearly activated, but intestinal damage has not yet become visible under the microscope. Your concern about the long-term risk of continued gluten consumption is valid, especially given your family's experience with the consequences of delayed diagnosis. Since your daughter is now at an age where her buy-in is essential for a gluten-free lifestyle, obtaining a definitive answer is crucial for her long-term adherence and health. Given that she is asymptomatic yet serologically positive, a third biopsy now, after a proper 12-week challenge, offers the best chance to capture any microscopic damage that may have developed, providing the concrete evidence needed to justify the dietary change. This isn't about wanting her to have celiac; it's about wanting to prevent the insidious damage that can occur while waiting for symptoms to appear, and ultimately giving her the unambiguous "why" she needs to accept and commit to the necessary treatment. This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. One test that always needs to be done is the IgA Levels/Deficiency Test (often called "Total IGA") because some people are naturally IGA deficient, and if this is the case, then certain blood tests for celiac disease might be false-negative, and other types of tests need to be done to make an accurate diagnosis. The article includes the "Mayo Clinic Protocol," which is the best overall protocol for results to be ~98% accurate.    
    • Scott Adams
      Welcome to the community! Generally, for a gluten challenge before celiac disease blood tests, Tylenol (acetaminophen) is considered safe and should not interfere with your antibody results. The medications you typically need to avoid are those like ibuprofen (Advil, Motrin) or naproxen (Aleve) that can cause intestinal irritation, which could potentially complicate the interpretation of an endoscopy if you were to have one. However, it is absolutely crucial that you confirm this with either your gastroenterologist or your surgeon before your procedure. They know the specifics of your case and can give you the definitive green light, ensuring your surgery is comfortable and your celiac testing remains accurate. Best of luck with your surgery tomorrow
    • Xravith
      Thank you for the advice. I’ve actually never checked for nutritional deficiencies, but for as long as I can remember, I’ve always taken vitamin and mineral supplements — otherwise my symptoms get worse. This week I stopped eating gluten to confirm whether my symptoms are really caused by it. Starting next week, I’ll reintroduce gluten — it’s sad to go back to how I was before — but at least I’ll be able to take the necessary tests properly. I think the diagnostic process will be long, but at least I’m happy that I finally decided to address this doubt I’ve had for years.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.