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Is there a Type I and Type II Celiac Disease IF so what is your Type: What the Diabetic Model can tell us about Celiac Disease Subtypes?

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Posterboy

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Is there a Type I and Type II Celiac Disease IF so what is your Type: What the Diabetic Model can tell us about Celiac Disease Subtypes?



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****these opinions are my own and are not an endorsement by Celiac.com….these are only my conclusions after years of research. 

I am sharing to generate thought, feedback, opinions, progress on the topic and change if they make sense to you.

I would say there are two types of Celiac disease based on all the available research I have read.

Think Type I and Type II like diabetes. I share/post this for your feedback, education, careful thought, insight and opinion(s).

Maybe it will spur your thinking! This Model of a "Type I" and "Type II" Celiac disease explains best what is happening IMO!

These type of grand break though ideas deserve to be shared on Celiac.com.....I suspect it will be another 10 or 15 years 

(IF then) that this "Working  Hypothesis" will be confirmed with more studies proving IT is a "Working Theory"....I just hope some

intrepid medical who might read this will be courageous enough to do a a thorough study on this topic confirming my many years of

research as the Lord has been my help!

I only ask that you be Berean in your thought! as you read this Posterboy blog post and Consider what I say....

Acts 17:10, 11

10 And the brethren immediately sent away Paul and Silas by night unto Berea: who coming thither went into the synagogue of the Jews.

11 These were more noble than those in Thessalonica, in that they received the word with all readiness of mind, and searched the scriptures (research) daily, whether those things were so.

Type I happens as a kid (refractory often)... and Type II happens as an adult (often triggered by PPIs or Stress) see below...

and why kid's don't get better (probably)....the age you get these deficiencies effects your bodies response....

triggered, in part, by congenital Vitamin deficiencies in children IMO.

I concluded this based on research I recently discovered about how Riboflavin aka Vitamin B2 can affect Villi formation in children……

and why it was first diagnosed in Children in IMO.

See these links on Riboflavin....I will summarize....if you get low Riboflavin, Thiamine etc. as a kid...you villi won't recover but if it happens

as an adult you can recover from PPIs (low stomach acid) triggered Celiac disease.

Here is the research on Riboflavin and Thiamine and Niacin and how they work together to regulate our immune system.

https://pubmed.ncbi.nlm.nih.gov/7857908/ 

https://www.ncbi.nlm.nih.gov/pubmed/8785207

https://www.sciencedirect.com/science/article/pii/S0278691510002474

 

thiamine and riboflavin together

https://www.sciencedirect.com/science/article/abs/pii/S1734114016302729

 

thiamine, riboflavin and niacin together completely down regulated inflammation/toxicity...

https://www.ncbi.nlm.nih.gov/pubmed/30903555

 

If this Posterboy blog post doesn’t make sense to you? It will have to be someone else to rediscover this again in 15 to 20+ years...

 

I have tried to educate the best I could! Too Educate is Too Free!!!!

I have tried to share how supplementing with B-Vitamins helped my GI problems, but it seems/seemed to be a “bridge to far” for some….

May this Posterboy blog post....help you "bridge" over the connection between Genetics and Environment IE....Epigenetics...(STRESS)

To discovery this I haven't cared what the truth is....I have just wanted it as it is!  Truth Frees us from Error!

I only know that......

Magnesium, Thiamine, Riboflavin and Niacin(amide) changed my life!

****note this comments that follows are notes to myself that quickly summarize these points (written previously) as cliff notes version of the above...(this I wrote for you as a summary for myself)

 

"Low stomach acid triggered by stress and we lock in with antacids..

Then being low in stomach aid makes you low in Magnesium in 6 months..

Being low in Magnesium makes thiamine unavailable to the body

When thiamine is low – you get low in Riboflavin after a month..

And villi begin swelling --- affecting absorption of other nutrients..

Then because riboflavin is a cofactor for Niacin synthesis via the Kyneurine pathway….

and you develop perfuse Skin Lesions diagnosed as DH…

When low in meat and dairy (or take mitochondria toxic medicine) you develop pellagra when you can’t synthesize

niacin from low tryptophan and riboflavin levels…"

 

This has recently been confirmed in IMO by the discovery that Tryptophan can be used as Therapeutic in the treatment of Celiacs…

https://www.news-medical.net/news/20201022/Tryptophan-found-in-turkeys-can-accelerate-intestinal-healing-in-people-with-celiac-disease.aspx

 

Otherwise you rest/settle on just having (PSP) aka Pellagra Sine Pellagra (think thyroid problems) Or Pellagra without Skin Involvements…

https://pubmed.ncbi.nlm.nih.gov/3809170/   

 

If this is triggered by infantile Beri Beri or more probably a Riboflavin deficiency your Villi might never recover...

SIDS  has been linked to a thiamine deficiency in kids.

Heck even in old age Beri Beri will cause blindness due to glaucoma...and 80pct of WE (brain version of Beri Beri) is not

diagnosed until autopsy upon death...

https://www.ncbi.nlm.nih.gov/pubmed/485004

 

Here is link https://academic.oup.com/ajcn/article/77/6/1352/4689829

 

focus on the riboflavin and gastrointestinal development paragraph...

quoting from that paragraph (read it all) it very informative...

"Recent work has shown that even when riboflavin is supplied to tissues intraperitoneally, the absence of riboflavin from the lumen

of the gastrointestinal tract from the time of weaning leads to a disruption of normal gastrointestinal development in rats."

 

Meaning in young children probably 2 or 3 years or young never (maybe up to 5 years of age estimate only)

(fully) develop Villi if their mother was also low in Riboflavin....

cleft palates develop this way....Riboflavin deficiencies in new born baby's.....Vitamin deficiencies passed from mother to baby....

The below link was recently rediscovered by me even though it is almost 10 years people don't know its role in regulating

our immune system our helping keep our GI tract healthy

Here is Riboflavin’s role in protecting against the Heatshock protein in SIBO

https://www.sciencedirect.com/science/article/pii/S0278691510002474

Entitled

"Riboflavin protects mice against liposaccharide-induced shock through expression of heat shock protein 25" in SIBO.

This also probably happening in Celiac disease as well…..we can surmise if it helps one of the GI disease’s that mimic

Celiac disease….it could help Celiac disease as well.

See this old forgotten article about how SIBO is common in Celiac disease.

Entitled Bacterial Overgrowth of Small Intestine aka SIBO Common in Treated Celiac Disease

https://www.celiac.com/articles.html/bacterial-overgrowth-of-small-intestine-common-in-treated-celiac-disease-r791/

Note: a couple things here….this Is not suspected Celiac disease but “Treated Celiac Disease”…..

SIBO is common in treated Celiac disease….meaning these were people eating a gluten free diet already….

And as I often site and say in my Posterboy blog post this research 10 or 15+ years old….

And yet people (doctor’s/clinician’s) are not aware of these connections/associations….

I set out to confirm my diagnosis and it took me approx. 4+ years to realize I had Low/NO stomach acid going un/misdiagnosed.

I have continued studying since then….and I am convinced now more than ever 10 to 12+ years later

that Low/NO stomach acid could help Celiac’s…..

But we have a “Long Tail” Memory…..and can’t seem to move onto another possible diagnosis like

Low/NO stomach acid despite what the research seems to say!

I am not the first to discover, study or conclude this…

This was studied 30+ years ago....but through much study and the grace of God I have rediscovered it.....

will it be another 10 or 15 years before it is accepted??? I hope and pray not! But I honestly don't have much hope....

That people will read it and believe it.....it has been lost for 30+ years for a reason.....nobody believes it!

See this research entitled

Gastric morphology and function in dermatitis herpetiformis and in C(o)eliac disease.

https://pubmed.ncbi.nlm.nih.gov/3992169/

quoting

“Antrum-sparing chronic atrophic gastritis was present in 92% of the achlorhydric patients, and hypergastrinaemia and

serum parietal cell antibodies were found in most of them. The prevalence of chronic gastritis of the body and of the

antrum increased with age.”

Note again: this was not in NCGS patients….but diagnosed Celiac and DH patients….

Surely Low/NO stomach acid is the trigger for Celiac disease.

IF this is so we would see the same thing in PPIs users…

And WE do….recent research confirmed this analysis….among PPIs users….for those who used them for a year or more

Low Stomach Acid (from PPIs Acid reducers) were found to be the trigger (CAUSE) of their Celiac diagnosis!

See this article about it on Celiac.com entitled “Do Proton Pump Inhibitors Increase Risk of Celiac Disease”

https://www.celiac.com/articles.html/do-proton-pump-inhibitors-increase-risk-of-celiac-disease-r2860/

They summarize it very well….

Quoting

“The data clearly show that patients who use anti-secretory medications are at much greater risk for developing

celiac disease following the use of these medicines. The fact that this connection persisted even after the team excluded

prescriptions for anti-secretory medicines in the year preceding the celiac disease diagnosis suggests a causal relationship.”

 

See also this thread started by Knitty Kitty

https://www.celiac.com/forums/topic/117685-atrophy-associated-with-ppis-nsaids-and-ssris/

Back to the main point of this Posterboy blog post….Low stomach is triggerable and reversible a “Type II” Celiac disease.

A congenital Celiac disease diagnosed as a kid…could not be reversed (in most people)….

and why it was originally diagnosed as a “Type I” genetic disease once Celiac antibodies were discovered IMHO.

I don’t believe it fair to someone who at 40 or 50 started taking PPIs to then tell them…you now have a genetic disease….

No, it was triggered by your PPIs usage….and is reversible like most EPI (Environmentally) genetic triggered diseases are….

B-Vitamins are the very definition of Epigenetics….you got low in Vitamins….and you got a disease from the deficiency….

This might not show up for years….until the Doctor’s recognize as a deficiency…..hence a “Type II” diagnosis!

I have written a couple other Posterboy blog posts that might help you. An “Open Letter” Part 1 and Part 2 that explains

how these things are connected if you think it would help you to read some more on these connections.

I didn’t understand it at the beginning of my journey, but I hope it will help start you on your journey back to heath as it did me!

It has been a long journey for me….but It can be short(er) for you….because you know the way back….I have shown you how I got back!

https://www.celiac.com/blogs/entry/2167-open-letter-part-1-to-fellow-gi-sufferers-etc-like-ibs-uc-and-other-gi-diseases-like-infant-heartburn-gerd-that-grows-into-in-time-to-ibs-uc-chrons-and-ncgs-as-a-teenager-or-celiac-disease-in-time-as-an-adult-look-beyond-to-the-parent-disease/

https://www.celiac.com/blogs/entry/2515-open-letter-to-the-many-gi-sufferers-part-2-still-suffering-look-beyond-these-symptom%E2%80%99s-to-the-parent-disease-pellagra-with-these-many-unruly-children-like-ibs-gerd-uc-etc-up-to-and-including-ncgs-and-celiac-disease-in-time-i-believe-part-2/

Just trying to help those still suffering (I believe) unnecessarily. Who think there is only one Type of Celiac disease?

2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ,

the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation,

that we may be able to comfort them which are in any trouble, by the comfort wherewith

we ourselves are comforted of God.”

I hope this is helpful but it is not medical advice.

2 Timothy 2:7  As always, “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the Grace of God,

ADDENDUM:

I am adding this Posterboy blog post from an earlier blog post maybe it will help you….

https://www.celiac.com/blogs/entry/2103-why-and-how-pellagra-is-often-confused-with-celiac-disease-andor-other-gidigestive-problems-the-science-of-pellagra-a-hidden-epidemic-in-the-21st-century-presentingrevealing-as-ncgs-andor-possbily-celiac-disease/

At the time not many people read it…..but maybe this time more people will read and understand it!

The presenting symptom of DH in Celiac disease is confirmation that the Kynurenine Pathway has broken down

and who have developed the 3rd "D" of Pellagra….

Let’s  hope the doctors realize this before the 4th "D" symptom DEATH occurs!

Since 80 percent of Wernicke Encephalopathy better known as the mental/brain symptom of Beri Beri is diagnosed on autopsy

I have my doubts they will notice the Pellagra Co-morbid in 58% (Majority) of Celiac noted no less than by the IJCD

(see Posterboy blog post link above) and why I continued to emphasis this in my Posterboy blog posts…..

because the IJCD noted the same thing!

I  only ask that you believe you own research (prophets)…..and agree with them that

Beri Beri, Pellagra Sine Pellagra, and Pellagra is happening in Celiac’s.

https://www.celiac.com/articles.html/how-low-thiamine-can-thin-villi-old-research-rediscovered-and-its-clinical-significance-in-celiac-disease-r5100/:~:text=Beriberi%20is%20is%20caused%20by%20low%20thiamine%20(B1).,dietary%20thiamin%20deficiency%20on%20intestinal%20functions%20in%20rats.”

At what rate only more tests/studies can prove. I ask that others in the Celiac community that might read this….

Do these studies….so that future doctors are aware of these connections/associations.

I just know we can't wait another 10 or 15 years before this trickles down to the clinical (Medical) level when current (today's)

research shows that Tryptophan can be used as a Therapeutic for Celiac disease.....IMHO confirming this theory!

https://www.celiac.com/articles.html/tryptophan-in-turkey-meat-can-speed-gut-healing-in-celiac-disease-r5338/

Isn't that we ALL want to speed our healing!

This is happening in other auto-immune diseases too/also because we only have ONE immune system!

With many difference (faces)….IE symptom’s…..

Note: Pellagra is found in Lupus too!

https://www.celiac.com/blogs/entry/2709-the-lupus-inflammation-model-for-sickness-beginning-with-b-vitamin-deficiencies-in-celiacs-and-other-inflammation-triggered-diseases%E2%80%A6/   

I must stop for now, or this will be way too long again!

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It is interesting. I do take PPIs as an adult. But I also was mysteriously ill often as a child and no one knew why, just wrote me off as sickly (migraines, vomiting, short and thin until I was 11-12).

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