Jump to content

  • You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.


  • Celiac.com Sponsor (A1):
    Celiac.com Sponsor (A1-M):

Celiac Disease & Gluten-Free Diet Blogs

Pete Dixon

Another conversation with ChatGPT about hookworms

<ME> i have extreme reactivity to gluten and ulcerative colitis, or at least I do when not on hookworms. this is accompanied by broad food sensitivities. when using hookworms I am essentially normal, no symptoms doesn't this simply point to the idea my gut immune system is ok, but an expected link in the chain has to be there, and that link is hookworms <ChatGPT>I’ll answer this as a mechanistic interpretation, not as a diagnosis. The important distinction is “hookworms are repl
dixonpete

dixonpete in Hookworms

2
celiac

Diagnosis

A few of the symptoms overlap, so it takes doctors longer to diagnose both diseases. Most specialists don't know about how the two diseases interact.
Name
3
Pete Dixon

There is a difficulty getting hookworm larvae into the US

With Donald Trump’s removal of the de minimis exemption for packages entering the United States, there has been increased scrutiny of inbound shipments, including those from helminthic therapy providers. The practical effect appears to be a near stoppage of Necator americanus larvae entering the U.S. I’ve previously written about incubation and self-supply, but that approach presupposes an existing infection capable of producing harvestable eggs. For new people access is now significantly c
dixonpete

dixonpete in Hookworms

1
Thiamine Thiamine Thiamine

Why Are Dietary Interventions Still Not Mainstream?

"Why Are Dietary Interventions Still Not Mainstream? While there is greater knowledge of the effects of pharmaceutical therapies for arthritis, there is less knowledge of the effects of many nutrients. And even though there is evidence that physician discussions of diet make a positive influence on patient dietary selections, these conversations are not common in clinical practice. There is a global deficiency of nutrition education in physician training, including the use of nutrients to m
knitty kitty
0
Thiamine Thiamine Thiamine

Glioblastoma and Niacin

I found this article about a study using high doses of Niacin to treat Glioblastoma.  Glioblastoma is an aggressive brain cancer. My mother died from Glioblastoma.   Can a Common Vitamin Fight the Most Aggressive Brain Cancer? https://scitechdaily.com/can-a-common-vitamin-fight-the-most-aggressive-brain-cancer/  And... A phase I-II study of niacin in patients with newly diagnosed glioblastoma: safety and interim phase II analysis https://link.springer.com/artic
knitty kitty
0
Thiamine Thiamine Thiamine

Is Thiamine Deficiency the Beginning of Celiac Disease?

I've been researching Celiac disease and Thiamine deficiency for a long time.  Recently I found information that shows a relationship between the lack of Thiamine and Celiac Disease pathogenesis.  What do you think? Thiamine is used in the mitochondria to produce energy (ATP) in the body for cells use as they go about their various functions.  Various chemical reactions take place as the glucose moves through the transport chain in the mitochondria.  Oxygen is needed at the end of the trans
knitty kitty
1
Thiamine Thiamine Thiamine

Thiamine Deficiency, Hypoxia, and Autoimmune Disease

Thiamine deficiency causes hypoxia.  Hypoxia-Inducible Factor 1α binds to thiamine transporter SLC19A3 and activates it to increase thiamine uptake.  HIF-1α signaling also triggers the release of inflammatory cytokines and inflammatory cells proliferation.  HIF-1a affects genes in the nucleus, entering through micro-pores.  Hypoxia and high levels of HIF-1a are found in many autoimmune diseases and cancer. "HIF-1α shows its functions through translocating into the nucleus, dimerizing with H
knitty kitty
0
Thiamine Thiamine Thiamine

Thiamine and Autoimmune Diseases

Thiamine and Autoimmune Diseases Human Leukocyte Antigens are coded for in our DNA.  They act like street signs on cells so the body knows that they are "Self".   Tissue typing in organ transplantation looks for donors with "Self" street signs similar to the recipient's in order to prevent rejection of the transplanted organ.   The HLA DQ genes code for immune cells.  Some immune cells are encoded to recognize certain protein strings when that protein string attaches to the receptor on
knitty kitty
2
Thiamine Thiamine Thiamine

Thiamine and Diabetes

People with diabetes may have genetic variations that cause their thiamine transporters to not absorb thiamine as well.  This functional thiamine deficiency can cause inflammation and diabetes.  Thiamine is needed to down regulate the inflammatory cytokines.   Genetic Variants of the Human Thiamine Transporter (SLC19A3, THTR2)—Potential Relevance in Metabolic Diseases https://pmc.ncbi.nlm.nih.gov/articles/PMC11988879/ Thiamine, gastrointestinal beriberi and acetylcholine sign
knitty kitty
0
Thiamine Thiamine Thiamine

Dairy and Celiac: studies

Bovine milk caseins and transglutaminase-treated cereal prolamins are differentially recognized by IgA of celiac disease patients according to their age https://pubmed.ncbi.nlm.nih.gov/19290628/   Gliadin and Casein Metabolism: Synthesis of Gliadomorphin and Casomorphin and Their Biological Consequences https://www.researchgate.net/publication/397908713_Gliadin_and_Casein_Metabolism_Synthesis_of_Gliadomorphin_and_Casomorphin_and_Their_Biological_Consequences   Effec
knitty kitty
0
Amiah

Help!!

Took six-year-old two pediatrician complaining a frequent stomach aches. Did blood testing for celiac and she is IGA deficient. The next thing they tested for was tissue transglutaminase antibody igG and this came back positive with a normal range less than 15, her number was 87.9 so they referred us to a Gastro doctor. The gas doctor said that with this number there is a 99% chance of celiac, but they would like to do a scope to verify. We did a scope and everything looked good and they took sa
Amiah

Amiah in Celiac??

3
Pete Dixon

Inoculation day!

I did the hookworm larva collection and inoculation today. It took 1/2 hr with doing everything right and safely, including clean-up. You can see the 5 jars I prepared a week ago in the pic. Only #2 jar had a good number of larvae so it was the only jar I used. I placed enough drops onto a checker board scored Petri dish until I had 25 and soaked them up onto a gauze bandage. It wasn't worth the effort to pipette out one extra larva in the last drop so I ended up with 26 this time. Thi
dixonpete

dixonpete in Hookworms

0
Thiamine Thiamine Thiamine

My Story Chapter Two

My health declined when I was taking an SSRI.  I learned that certain drugs can cause Thiamine deficiency.  SSRI's are one of those drugs.  Depression is a symptom of Thiamine deficiency.  It's also a symptom of Vitamin D deficiency. I was eating the Standard American Diet at the time, which is a diet that causes High Calorie Malnutrition.  Consuming large amounts of carbohydrates without a corresponding increase in Thiamine causes a Thiamine deficiency.  For every extra 1000 calories an ad
knitty kitty

knitty kitty in My Journey

0
Thiamine Thiamine Thiamine

My Story

Yes, I do have Celiac disease.  I had symptoms since infancy, but they were explained away as character flaws.  I was told my stomach aches were faked to avoid going to school and other responsibilities, or to spoil family fun, and that my Dermatitis Herpetiformis was caused by being dirty and not bathing properly.  I wasn't diagnosed with Celiac until midlife. My various health problems for which I sought medical attention were treated as separate entities.  No medical professional looked
knitty kitty

knitty kitty in My Journey

1
Gluten Busters: Gluten-Free Product Alerts by Celiac.com

Koikoi Trading Inc., Issues Allergy Alert on Undeclared Wheat and Sesame in FU ZHOU FISH BALL

Commerce, CA – Koikoi Trading Inc. is recalling certain lots of FU ZHOU FISH BALL products in multiple pack sizes (200g, 400g, and 5LB) because the products may contain undeclared allergens: wheat and sesame. People who have an allergy or severe sensitivity to wheat and/or sesame run the risk of a serious or life-threatening allergic reaction if they consume these products. The products were distributed through foodservice and e-commerce channels and may have reached consumers through direc
Scott Adams

Scott Adams in USA Recalls

0
Thiamine Thiamine Thiamine

About Celiac Remission

Exposure to gluten (and casein in those sensitive to it) can cause an increased immune response and inflammation for months afterwards.  The immune cells that make tTg IgA antibodies which are triggered today are going to live for about two years. During that time, inflammation is heightened.  Those immune cells only replicate when triggered.  If those immune cells don't get triggered again for about two years, they die without leaving any descendents programmed to trigger on gluten and cas
knitty kitty
1
Thiamine Thiamine Thiamine

Vitamins I Take

I like Life Extension Bioactive Complete B Complex.  It contains the easily activated forms of B vitamins needed by people with the MTHFR genetic variation often found with Celiac disease.   Avoid B Complex vitamins if they contain Thiamine Mononitrate if possible.  (Read the ingredients listing.)  Thiamine Mononitrate is the "shelf-stable" form of B 1 that the body can't utilize.  B vitamins breakdown when exposed to heat and light, and over time.  So "shelf-stable" forms won't breakdown s
knitty kitty
0
Thiamine Thiamine Thiamine

Nutrition and Gluten free diet

Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements https://pubmed.ncbi.nlm.nih.gov/10919966/ The effects of endurance training and thiamine supplementation on anti-fatigue during exercise https://pmc.ncbi.nlm.nih.gov/articles/PMC4241913/ Effects of thiamine supplementation on exercise-induced fatigue https://pubmed.ncbi.nlm.nih.gov/8815395/ Exploring the Relationship between Micronutrients and Athletic Performance: A Comprehensive Scie
knitty kitty
0
Thiamine Thiamine Thiamine

Gastrointestinal Beriberi

Thiamine, gastrointestinal beriberi and acetylcholine signaling https://pmc.ncbi.nlm.nih.gov/articles/PMC12014454/#ref3 https://pmc.ncbi.nlm.nih.gov/articles/PMC12014454/#ref3 From Section 3: "In conclusion, TD limited to the gastrointestinal system may be an overlooked and underdiagnosed cause of the increasingly common gastrointestinal disorders encountered in modern medical settings. Left unattended, it may progress to wet or dry beriberi, most often observed as Wernicke e
knitty kitty
1
Gluten Busters: Gluten-Free Product Alerts by Celiac.com

Häagen-Dazs Chocolate Dark Chocolate Mini Bars Recall Due to Undeclared Wheat and Gluten

Dreyer’s Grand Ice Cream, Inc. has issued a voluntary recall of certain Häagen-Dazs Chocolate Dark Chocolate Mini Bars due to undeclared wheat, which may pose a serious risk to those with wheat allergies or sensitivities. Product Details Product: Häagen-Dazs Chocolate Dark Chocolate Mini Bars (6-count) Batch code: LLA519501 Best By date: 31 JAN 2027 How to check: Look for batch code LLA519501 under “Best By 31 JAN 2027” on the package. Where Sold Kro
Scott Adams

Scott Adams in USA Recalls

0
Pete Dixon

Inoculation and video development

On September 23, 2025, I did my latest inoculation. It was right around the five-month mark — plenty of time to avoid the expected adult hookworm die-off in my gut at around 6 to 6.5 months. I never noticed any interruption of “worm services.” Neither my gluten reactions nor the colitis ever reared their ugly heads, so it appears I had a smooth transition with the new hookworms. This time, out of the five small jars I prepared, four were almost entirely vacant of larvae — but one was hoppin
dixonpete

dixonpete in Hookworms

0
Gluten Busters: Gluten-Free Product Alerts by Celiac.com

Amy's Gluten-Free Burritos Recalled for Possible Foreign Material Contamination

Amy’s Kitchen has initiated a recall of select Gluten Free Bean & Rice Burritos due to potential foreign material, according to current recall listings. The affected retail unit is 5.5 oz with lot code 30C1725 and an expiration date of 03/2027. Distribution included multiple U.S. states. Specific foreign material was not disclosed in public summaries at the time of writing. Why This Matters for Celiac Disease and Gluten Sensitivity Gluten-free shoppers rely on accurate labeling and
Scott Adams

Scott Adams in USA Recalls

0
Gluten Busters: Gluten-Free Product Alerts by Celiac.com

Doan’s Bakery Issues Allergy Update on Undeclared Wheat and Milk Allergens in Bundt Cakes

Doan’s Bakery of Woodland Hills, CA is recalling White Chocolate Coconut and Carrot Bundt Cakes because they may contain undeclared wheat and milk. People who have an allergy or severe sensitivity to wheat and/or milk run the risk of experiencing a serious or life-threatening reaction if they consume these products. The recalled bundt cakes were sold by Doan’s Bakery and distributed nationwide via mail order via goldbelly.comExternal Link Disclaimer from June 1, 2025 through September 24, 2
Scott Adams

Scott Adams in USA Recalls

0

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Blog Comments

    • dixonpete
      Another conversation with ChatGPT about hookworms

      I suppose it's all in how you ask the question. I just asked ChatGPT how much it would cost to resolve my gut issues the way hookworms have, and ChatGPT's response was "$15,000–$30,000/year for the most plausible UC biologic/small-molecule route, or $10,000–$40,000+/year for omalizumab-style allergy modulation".

      That assumes such medication actually worked. Considering that all I have now is a reactivity to nuts, I'm highly doubtful that a drug result would even come close to what hookworms achieve for me for free (free because I incubate).

      I completely agree that most celiacs won't get a free pass on gluten from hookworms. However, I also do believe that most celiacs would have their reactivity to gluten reduced, some greatly so, and that has value. My own reactions to gluten when I'm not on hookworms are catastrophic, completely disabling, even when the exposure is small. I'm completely free of that now. Would you seriously argue I am making the wrong choice?

    • Scott Adams
      Another conversation with ChatGPT about hookworms

      My question to ChatGPT:
      Is purposeful Hookworm infection a reasonable treatment for those who have many food intolerance issues, including those with gluten intolerance who want to eat gluten?

      Answer:

      No — purposeful hookworm infection is not a reasonable or medically accepted treatment for broad food intolerance, gluten intolerance, or for people with celiac disease who want to eat gluten.

      There is real research behind the idea: hookworms can alter immune responses, and small celiac studies explored whether Necator americanus infection might make gluten exposure less symptomatic. But the best placebo-controlled trial found that hookworm infection did not restore tolerance to sustained gluten intake of 2 grams per day. It was associated with some symptom/quality-of-life improvements, but not enough to make gluten safe or to replace a gluten-free diet. (PubMed)

      For celiac disease, this is especially important: fewer symptoms does not necessarily mean the immune injury is gone. A person could feel better while still risking villous damage, nutrient deficiencies, anemia, bone loss, neurologic issues, infertility risks, or other complications from gluten exposure. The only established treatment remains a strict gluten-free diet.

      For non-celiac gluten sensitivity or multiple food intolerances, hookworm therapy is even less justified. Food intolerance can come from many causes: IBS/FODMAP sensitivity, lactose or fructose intolerance, histamine issues, mast-cell disorders, SIBO, bile acid problems, eosinophilic GI disease, medication effects, true food allergy, or poorly controlled celiac disease. Infecting oneself with a parasite does not diagnose or reliably treat those.

      There are also real risks: hookworms can cause abdominal symptoms, rash at the entry site, anemia/iron deficiency, eosinophilia, protein loss, and complications in people who are pregnant, immunocompromised, underweight, anemic, or medically fragile. Helminth therapy is not FDA-approved as a treatment, and outside a regulated clinical trial it is basically self-experimentation with a live parasite. (Medical News Today)

      A safer path would be: confirm whether this is celiac disease, wheat allergy, or non-celiac gluten sensitivity; check for nutritional deficiencies and inflammation; and work with a gastroenterologist/allergist/dietitian on a structured elimination-and-rechallenge plan. For someone with celiac disease who wants future gluten tolerance, the more reasonable options are legitimate clinical trials of drugs, enzymes, immune therapies, or vaccines — not deliberate parasite infection.

×
×
  • Create New...