Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Has Anyone Heard Of Being Iga And Igg Deficient?

Aurora87

Recommended Posts

Aurora87 Newbie
Aurora87
Posted

As I wrote about before, I am in the process of trying to figure out if I have celiac disease.  However, my bloodwork all comes out negative because I have IgA and IgG subclass 2 and 3 deficiencies.  

 

Has anyone else heard of having both IgA and IgG deficiencies?  I guess the biopsy would be the only way to know for sure if I have celiac, right?  I have read about having an IgA deficiency, but not both.  My doctor wants me to see an immunologist about it.  Thanks!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


1desperateladysaved Proficient
1desperateladysaved
Posted

I wish I had the answer to this as I have asked on a few occasion, but haven't figured it out.  I suspect that I had been deficient in both.

 

Dee

SMRI Collaborator
SMRI
Posted

It's very "common".  My daughter is IgA deficient and IgG subclass 2, 3 and 4 deficient.  It's usually classified as CVID Open Original Shared Link .

 

Each of the IgG subclasses point to different symptoms, 2 and 4 relate to upper respiratory issues--lots of sinus infections, strep, pneumonia, etc.  Subclass 3 is digestive issues--which is why it's important to get these tests if you suspect some gluten issues---it might not be gluten and it might just be low IgG3.  If your overall IgG is low, you have some pretty major health issues and usually land in the hospital every time you get sick.  If you are old enough to remember the movie "Boy in the Plastic Bubble", that is what he had in the movie.

 

If you are going to need a biopsy only diagnosis because of low IgA and IgG, ask that they take a LOT of samples-10 or so.

Aurora87 Newbie
Aurora87
Posted
  • Author

Wow, thanks for your replies.  It's comforting to know this information.  I do remember hearing something about the "Bubble Boy" but I'm glad I'm not that deficient!  I have an appointment at the Celiac Disease Center at Columbia University in mid-October and I will bring all my test results with me.  I do think I probably need a biopsy and I will be sure that they are going to take a lot of samples.  If everything is clear, my next stop will be the immunologist.

 

Just out of curiousity, SMRI, does your daughter have celiac disease or gluten sensitivity?  I would think that eliminating gluten and thus eliminating a source of inflammation might help if you have immune deficiencies, but I'm not an expert.  I will probably try a gluten free diet even if I don't have celiac to see if it helps me. 

 

Have a great weekend!

SMRI Collaborator
SMRI
Posted

Wow, thanks for your replies.  It's comforting to know this information.  I do remember hearing something about the "Bubble Boy" but I'm glad I'm not that deficient!  I have an appointment at the Celiac Disease Center at Columbia University in mid-October and I will bring all my test results with me.  I do think I probably need a biopsy and I will be sure that they are going to take a lot of samples.  If everything is clear, my next stop will be the immunologist.

 

Just out of curiousity, SMRI, does your daughter have celiac disease or gluten sensitivity?  I would think that eliminating gluten and thus eliminating a source of inflammation might help if you have immune deficiencies, but I'm not an expert.  I will probably try a gluten free diet even if I don't have celiac to see if it helps me. 

 

Have a great weekend!

 

She is not Celiac.  The two really aren't the same thing, although they have similar symptoms.  Her issues are more with getting sick all the time but she does have some digestive issues that again, are similar to Celiac but not because of gluten.

LauraTX Rising Star
LauraTX
Posted

Sorry to arrive to this thread late.  SMRI gave you some great info.  I have Celiac disease and also have Common Variable Immunodeficiency with IgG and IgA deficiencies and reduced vaccine response.  CVID and low immunoglobulin levels can cause false negatives in some Celiac blood tests, and false mild positives in biopsy samples for Celiac diagnosis.  You are very lucky to have a good doctor who checked the total immunoglobulin levels.  Get on in to the immunologist... as you have indicated an understanding of already, there are varying degrees of immune deficiency issues, so the immunologist will be able to determine what is going on, and then you can bring that information to the Celiac clinic so they know what they need to do to properly diagnose you.  Autoimmune disorders are prevalent in people with CVID.  Let us know what they say, I am always very interested in any other Celiac/CVID patient other than myself.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. Scott Adams
      - Scott Adams replied to HAUS's topic in Gluten-Free Foods, Products, Shopping & Medications
      7

      Sainsbury's Free From White Sliced Bread - Now Egg Free - Completely Ruined It

      In the U.S., most regular wheat breads are required to be enriched with certain B-vitamins and iron, but gluten-free breads are not required to be. Since many gluten-free products are not enriched, we usually encourage people with celiac disease to consider a multivitamin. In the early 1900s, refined white flour replaced whole grains, and people began...
    2. Scott Adams
      - Scott Adams replied to deanna1ynne's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      13

      Inconclusive results

      Keep in mind that there are drawbacks to a formal diagnosis, for example more expensive life and private health insurance, as well as possibly needing to disclose it on job applications. Normally I am in favor of the formal diagnosis process, but if you've already figured out that you can't tolerate gluten and will likely stay gluten-free anyway, I wanted...
    3. JoJo0611
      - JoJo0611 replied to JoJo0611's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      6

      CT with contrast.

      Thank you.
    4. deanna1ynne
      - deanna1ynne replied to deanna1ynne's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      13

      Inconclusive results

      Thank you all so much for your advice and thoughts. We ended up having another scope and more bloodwork last week. All serological markers continue to increase, and the doc who did the scope said there villous atrophy visible on the scope — but we just got the biopsy pathology report back, and all it says is, “Duodenal mucosa with patchy increased int...
    5. cristiana
      - cristiana replied to HAUS's topic in Gluten-Free Foods, Products, Shopping & Medications
      7

      Sainsbury's Free From White Sliced Bread - Now Egg Free - Completely Ruined It

      Thanks for this Russ, and good to see that it is fortified. I spend too much time looking for M&S gluten-free Iced Spiced Buns to have ever noticed this! That's interesting, Scott. Have manufacturers ever said why that should be the case?
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,441
    • Most Online (within 30 mins)
      7,748
    Linda Boxdorfer
    Newest Member
    Linda Boxdorfer
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Scott Adams
      Sainsbury's Free From White Sliced Bread - Now Egg Free - Completely Ruined It

      By Scott Adams · Posted

      In the U.S., most regular wheat breads are required to be enriched with certain B-vitamins and iron, but gluten-free breads are not required to be. Since many gluten-free products are not enriched, we usually encourage people with celiac disease to consider a multivitamin.  In the early 1900s, refined white flour replaced whole grains, and people began developing serious vitamin-deficiency diseases: Beriberi → caused by a lack of thiamin (vitamin B1) Pellagra → caused by a lack of niacin (vitamin B3) Anemia → linked to low iron and lack of folate By the 1930s–40s, these problems were common in the U.S., especially in poorer regions. Public-health officials responded by requiring wheat flour and the breads made from it to be “enriched” with thiamin, riboflavin, niacin, and iron. Folic acid was added later (1998) to prevent neural-tube birth defects. Why gluten-free bread isn’t required to be enriched? The U.S. enrichment standards were written specifically for wheat flour. Gluten-free breads use rice, tapioca, corn, sorghum, etc.—so they fall outside that rule—but they probably should be for the same reason wheat products are.
    • Scott Adams
      Inconclusive results

      By Scott Adams · Posted

      Keep in mind that there are drawbacks to a formal diagnosis, for example more expensive life and private health insurance, as well as possibly needing to disclose it on job applications. Normally I am in favor of the formal diagnosis process, but if you've already figured out that you can't tolerate gluten and will likely stay gluten-free anyway, I wanted to at least mention the possible negative sides of having a formal diagnosis. While I understand wanting a formal diagnosis, it sounds like she will likely remain gluten-free either way, even if she should test negative for celiac disease (Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If her symptoms go away on a gluten-free diet, it would likely signal NCGS).        
    • JoJo0611
      CT with contrast.

      By JoJo0611 · Posted

      Thank you. 
    • deanna1ynne
      Inconclusive results

      By deanna1ynne · Posted

      Thank you all so much for your advice and thoughts. We ended up having another scope and more bloodwork last week. All serological markers continue to increase, and the doc who did the scope said there villous atrophy visible on the scope — but we just got the biopsy pathology report back, and all it says is, “Duodenal mucosa with patchy increased intraepithelial lymphocytes, preserved villous architecture, and patchy foveolar metaplasia,” which we are told is still inconclusive…  We will have her go gluten free again anyway, but how soon would you all test again, if at all? How valuable is an official dx in a situation like this?
    • cristiana
      Sainsbury's Free From White Sliced Bread - Now Egg Free - Completely Ruined It

      By cristiana · Posted

      Thanks for this Russ, and good to see that it is fortified. I spend too much time looking for M&S gluten-free Iced Spiced Buns to have ever noticed this! That's interesting, Scott.  Have manufacturers ever said why that should be the case?  
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.