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Biopsy Results

cbcc1997

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cbcc1997 Newbie
cbcc1997
Posted

Good morning. I received a call on Friday that my biopsy was consistent with Celiac Disease. I received the report today and I am confused with results. This is what it said...

Patchy mild increase in the numbers of intra-epithelial lymphocytes.  The finding of intraepithelial lymphocytosis with preserved villous architecture is a non specific immunological phenomenon that has a large number of possible causes. A mild histological manifestation of gluten sensitivity is one of these causes. 

It then goes on to say that Serology for tissue transglutaminase/deaminated gliadin peptide antibodies is recommended. I believe that is the blood test which I have and is negative. There could by many causes that would increase the numbers. 

Has anyone experienced any report like this? Since my blood test was negative and there could be other causes, do I actually have Celiac Disease?

Thank you. :)

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cyclinglady Grand Master
cyclinglady
Posted

The TTG and the DGP tests are pretty specific for celiac disease.  You need to take a serious look at exactly what celiac blood tests were given.  Did you have the IGA deficiency test as well (it is a control test)?  Were you consuming gluten daily for 8 to 12 weeks prior to the blood draw?  This is the complete panel:

 
-Tissue Transglutaminase (tTG) IgA and (tTG) IgG
-Deamidated Gliadin Peptide (DGP) IgA and (DGP) IgG
-EMA IgA 
-total serum IgA and IgG (control test)
 
 
-endoscopic biopsy - make sure at least 6 samples are taken
 
(Source: NVSMOM -- ?)
 
How many biopsies were taken?  At what locations? I personally tested positive on ONLY the DGP IGA and the rest of the celiac blood panel was negative, yet I had severe damage.  They diagnosed you with a Marsh Stage I but there could be more damage.  The small intestine is the size of a tennis court if spread out.  Finding damagd  areas is easy to miss.  
 
I recommend that you follow the advice of the pathologist and have the COMPLETE celiac panel done.  Be sure to keep eating gluten.  And finally, do some more research on celiac disease.  We are talking about your health.  Untreated celiac disease leads to CANCER! ?

 

Welcome to the forum and let us know how it goes! 

 

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    • knitty kitty
      ttg iga high (646 mg/dl) other results are normal

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      @kpf, Were you eating ten grams or more of gluten daily in the month preceding your antibody blood tests? TTg IgA antibodies are made in the intestines.  Ten grams of gluten per day for several weeks before testing is required to provoke sufficient antibody production for the antibodies to leave the intestines and enter the blood stream and be measured in blood tests. If you had already gone gluten free or if you had lowered your consumption of gluten before testing, your results will be inaccurate and inconclusive.   See link below on gluten challenge guidelines. Have you had any genetic testing done to see if you carry genes for Celiac disease?  If you don't have genes for Celiac, look elsewhere for a diagnosis.  But if you have Celiac genes, you cannot rule out Celiac disease. You mentioned in another post that you are vegetarian.  Have you been checked for nutritional deficiencies?  The best sources of the eight essential B vitamins are found in meats.  Do you supplement any of the B vitamins as a vegetarian? Deficiency in Thiamine Vitamin B 1 is strongly associated with anemia which can cause false negatives on antibody tests.  Fatigue, numbness or tingling in extremities, difficulty with coordination, headaches and anemia are strongly associated with thiamine deficiency.  Other B vitamins that contribute to those symptoms are Riboflavin B 2, Pyridoxine B 6, Folate B 9 and B12 Cobalamine.  The eight B vitamins all work together with minerals like magnesium and iron.  So your symptoms are indicative of B vitamin deficiencies.  You can develop vitamin and mineral deficiencies just being a vegetarian and not eating good sources of B vitamins like meat.  B vitamin deficiencies are found in Celiac due to the malabsorption of nutrients because the lining of the intestines gets damaged by the antibodies produced in response to gluten.    
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      By Wheatwacked · Posted

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    • trents
      ttg iga high (646 mg/dl) other results are normal

      By trents · Posted

      Yes, I wondered about the units as well. That large number sure looked more like what we're used to seeing in connection with total IGA scores rather than TTG-IGA. The total IGA test is given to determine if you are IGA deficient. In the case of IGA deficiency, other IGA tests will b skewed and their scores cannot be trusted. Elevated total IGA can point to other health issues, some of them potentially serious, or it can mean nothing. But it doesn't look like you have celiac disease.
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