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Biopsy Results

cbcc1997

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cbcc1997 Newbie
cbcc1997
Posted

Good morning. I received a call on Friday that my biopsy was consistent with Celiac Disease. I received the report today and I am confused with results. This is what it said...

Patchy mild increase in the numbers of intra-epithelial lymphocytes.  The finding of intraepithelial lymphocytosis with preserved villous architecture is a non specific immunological phenomenon that has a large number of possible causes. A mild histological manifestation of gluten sensitivity is one of these causes. 

It then goes on to say that Serology for tissue transglutaminase/deaminated gliadin peptide antibodies is recommended. I believe that is the blood test which I have and is negative. There could by many causes that would increase the numbers. 

Has anyone experienced any report like this? Since my blood test was negative and there could be other causes, do I actually have Celiac Disease?

Thank you. :)

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cyclinglady Grand Master
cyclinglady
Posted

The TTG and the DGP tests are pretty specific for celiac disease.  You need to take a serious look at exactly what celiac blood tests were given.  Did you have the IGA deficiency test as well (it is a control test)?  Were you consuming gluten daily for 8 to 12 weeks prior to the blood draw?  This is the complete panel:

 
-Tissue Transglutaminase (tTG) IgA and (tTG) IgG
-Deamidated Gliadin Peptide (DGP) IgA and (DGP) IgG
-EMA IgA 
-total serum IgA and IgG (control test)
 
 
-endoscopic biopsy - make sure at least 6 samples are taken
 
(Source: NVSMOM -- ?)
 
How many biopsies were taken?  At what locations? I personally tested positive on ONLY the DGP IGA and the rest of the celiac blood panel was negative, yet I had severe damage.  They diagnosed you with a Marsh Stage I but there could be more damage.  The small intestine is the size of a tennis court if spread out.  Finding damagd  areas is easy to miss.  
 
I recommend that you follow the advice of the pathologist and have the COMPLETE celiac panel done.  Be sure to keep eating gluten.  And finally, do some more research on celiac disease.  We are talking about your health.  Untreated celiac disease leads to CANCER! ?

 

Welcome to the forum and let us know how it goes! 

 

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      Test interpretations

      By trents · Posted

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      Test interpretations

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      Based on those results alone, it’s not possible to say you have celiac disease. The test that is usually most specific for celiac, tTG-IgA, is negative in your results, and the endomysial antibody (EMA) is also negative, which generally argues against active celiac disease. However, your deamidated gliadin IgA is elevated, and your total IgA level is also high, which can sometimes affect how the other antibody tests behave. Another important factor is that you were reducing gluten before the test, which can lower antibody levels and make the results less reliable. Because of that, many doctors recommend a gluten challenge (eating gluten regularly for several weeks) before repeating blood tests or considering an endoscopy if symptoms and labs raise concern. It would be best to review these results with a gastroenterologist, who can interpret them in context and decide whether further testing is needed.
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