Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Biopsy Results

cbcc1997

Recommended Posts

cbcc1997 Newbie
cbcc1997
Posted

Good morning. I received a call on Friday that my biopsy was consistent with Celiac Disease. I received the report today and I am confused with results. This is what it said...

Patchy mild increase in the numbers of intra-epithelial lymphocytes.  The finding of intraepithelial lymphocytosis with preserved villous architecture is a non specific immunological phenomenon that has a large number of possible causes. A mild histological manifestation of gluten sensitivity is one of these causes. 

It then goes on to say that Serology for tissue transglutaminase/deaminated gliadin peptide antibodies is recommended. I believe that is the blood test which I have and is negative. There could by many causes that would increase the numbers. 

Has anyone experienced any report like this? Since my blood test was negative and there could be other causes, do I actually have Celiac Disease?

Thank you. :)

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


cyclinglady Grand Master
cyclinglady
Posted

The TTG and the DGP tests are pretty specific for celiac disease.  You need to take a serious look at exactly what celiac blood tests were given.  Did you have the IGA deficiency test as well (it is a control test)?  Were you consuming gluten daily for 8 to 12 weeks prior to the blood draw?  This is the complete panel:

 
-Tissue Transglutaminase (tTG) IgA and (tTG) IgG
-Deamidated Gliadin Peptide (DGP) IgA and (DGP) IgG
-EMA IgA 
-total serum IgA and IgG (control test)
 
 
-endoscopic biopsy - make sure at least 6 samples are taken
 
(Source: NVSMOM -- ?)
 
How many biopsies were taken?  At what locations? I personally tested positive on ONLY the DGP IGA and the rest of the celiac blood panel was negative, yet I had severe damage.  They diagnosed you with a Marsh Stage I but there could be more damage.  The small intestine is the size of a tennis court if spread out.  Finding damagd  areas is easy to miss.  
 
I recommend that you follow the advice of the pathologist and have the COMPLETE celiac panel done.  Be sure to keep eating gluten.  And finally, do some more research on celiac disease.  We are talking about your health.  Untreated celiac disease leads to CANCER! ?

 

Welcome to the forum and let us know how it goes! 

 

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,097
    • Most Online (within 30 mins)
      7,748
    Ann Den
    Newest Member
    Ann Den
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • trents
      High DGP-A with normal IGA

      By trents · Posted

      Your DGP-G is also high. The thing to do now would be to trial the gluten-free diet for a few months to see if there is improvement in symptoms.
    • trents
      GI DX celiac despite neg serology and no biopsy

      By trents · Posted

      Welcome to the forum, @Roses8721! How long were you off gluten before getting the celiac blood testing done? The testing is not valid after having been gluten free for a significant period of time. Many of your symptoms align with celiac disease.
    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

      Hello, I am feeling frustrated. I have hEDS and lifelong digestive issues but my GI PA is very focused on my celiac panel and I just want to make sure that she should be focused on that because completely changing my diet seems to have worsened my symptoms.  Symptoms are constipation, diarrhea, and acid reflux with spicy foods and certain foods like tomatoes, bell peppers, and onions. I also don't have a gallbaldder as it was removed almost a year ago. This also exacerbated my symptoms. I did have joint pain from hEDS but that was already treated with low dose naltrexone about 4 months prior to going completely gluten free. Endoscopy was abnormal but inconclusive; basically showed some inflammation - which common with hEDS. I don't have any vitamin deficiency.   Celiac Panel Results: TTG-A <0.5 U/ML Reference Range: 0.5-14.9 U/ML NEGATIVE: <15 POSITIVE: =>15 DGP-A 72.0 U/ML Reference Range: 0.2-14.9 U/ML NEGATIVE: <15 POSITIVE: =>15 TTG-G <0.8 U/ML Reference Range: 0.8-14.9 U/ML NEGATIVE: <15 POSITIVE: =>15 DGP-G 24.0 U/ML Reference Range: 0.4-14.9 U/ML NEGATIVE: <15 POSITIVE: =>15 IgG-A-M Results: IMMUNOGLOBULIN A, QN, SERUM 165 MG/DL Reference Range: 87-352 MG/DL IMMUNOGLOBULIN M, QN, SERUM 164 MG/DL Reference Range: 26-217 MG/DL   What are your thoughts, internet? Are there any questions I should be asking the PA? Thanks!
    • Roses8721
      GI DX celiac despite neg serology and no biopsy

      By Roses8721 · Posted

      Help. I’m spiraling. Years of extensive symptoms:  What could this be? Years of: Mildly elevated alk and alt Fatty liver Random days of feeling like I’m coming down w flu but no fever and nobody else in house sick Intermittent diarrhea Severe abdominal distension Long history of cavities and enamel deficiency Sound sensitivity Anxiety and depression Low libido Sun skin allergy Frequent fatigue ended up seeing PCP because I looked 8 mo preg. Started gluten-free diet then celiac serology negative. SW GI Dr dx me w celiac as I had been in bed for 3 days after eating gluten after cutting. GI said not to do biopsy because it was clear what was going on and added to chart. My spiral is not seeing anywhere this is done and want to see if anyone else has dealt w this. If not celiac idk what else I will do. Family history or celiac as well as a death related to this. 
    • miguel54b
      Canker sores

      By miguel54b · Posted

      I get canker sores one hour after eating Oats, and pimples in my butt. 
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.