Help with Lab Results

[JulieG]

Hello,

My 11 year old son recently had bloodwork done as he has had stomach aches and bathroom issues ever since having COVID in December.  His celiac panel all came back ok with the exception of the last test.  I should know more about this as my 8 year old daughter was diagnosed with celiac when she was 4 but her bloodwork looked completely different.  Are there other things that can cause an elevated IgG?  He has PANDAS and recently got lyme disease as well.  Thanks so much for your help!!!

PANEL: Celiac Ab tTG DGP TIgA

Immunoglobulin A, Qn, Serum - In range

Deamidated Gliadin Abs, IgA - In range

Deamidated Gliadin Abs, IgG - In range

t-Transglutaminase (tTG) IgA - Negative <2

t-Transglutaminase (tTG) IgG - 11 (HIGH)

 

[Scott Adams]

First, were there any number associated with the top 3 results that say "in range"? 

Also, it would be very helpful if you can include the scale for each test, so the normal vs. high marks, as different labs use different ranges.

I don't know what the normal was for the last test which was high, so please let us know the cut-off for normal vs. high. 

Just at a glance, and knowing the extra info you provided that his sister has been diagnosed with celiac disease, combined with the positive t-Transglutaminase (tTG) IgG - 11 (HIGH), I would say that the odds are your son may also have celiac disease. 

Also, is it possible that because his sister has it that he doesn't eat gluten daily? To get accurate blood tests he would need to eat about a slice of wheat bread daily for 12 weeks for the tests to be accurate. Here is more on that:

A recent study indicates that around 44% of first degree relatives also have celiac disease:

 

[JulieG]

Hi Scott.. thank you so much for responding.  I added some more detail into the results:

Immunoglobulin A, Qn, Serum 55 - In range 52- 221 

Deamidated Gliadin Abs, IgA - 4 - In range 0-19

Deamidated Gliadin Abs, IgG - 4 - In range 0-19

t-Transglutaminase (tTG) IgA - Negative <2 - Negative 0-3, weak positive 4-10, positive >10

t-Transglutaminase (tTG) IgG - 11 (HIGH) - Negative 0-5, weak positive 6-9, positive >9

Also, my son eats a lot of gluten.  Mostly gluten I would say.  

Thanks,

Julie 

48 minutes ago, Scott Adams said:

First, were there any number associated with the top 3 results that say "in range"? 

Also, it would be very helpful if you can include the scale for each test, so the normal vs. high marks, as different labs use different ranges.

I don't know what the normal was for the last test which was high, so please let us know the cut-off for normal vs. high. 

Just at a glance, and knowing the extra info you provided that his sister has been diagnosed with celiac disease, combined with the positive t-Transglutaminase (tTG) IgG - 11 (HIGH), I would say that the odds are your son may also have celiac disease. 

Also, is it possible that because his sister has it that he doesn't eat gluten daily? To get accurate blood tests he would need to eat about a slice of wheat bread daily for 12 weeks for the tests to be accurate. Here is more on that:

A recent study indicates that around 44% of first degree relatives also have celiac disease:

 

 

[Scott Adams]

Definitely get your doctor’s opinion on this, but give. everything you’ve shared I thing you’ve got two kids who need to be gluten-free. Be sure to share the study on rates of celiac disease among families with your doctor. They may not have the latest info on this.