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Blood test results


Darkside

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Darkside Rookie

I recently had Blood test done and the results was the fallowing.

Tested positive for  the IgA antibodies 

HLA-DQ2 Positive

HLA-DQ8 Negative

My internist wants to retest me to be sure the results were accurate before sending me for an endoscopy. how accurate is the bloodtest to diagnose celiac? 


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trents Grand Master

We can't tell you anything concerning your IGA test results with the information you have given us. IGA is not a test but a category including several different specific tests. Check this out: https://celiac.org/about-celiac-disease/screening-and-diagnosis/screening/ Can you list the specific tests that were run and the resulting values? We would also need reference ranges to be able to know what is considered normal or negative and what is considered positive. Different labs use different reference ranges.

You have one of the two genes that have been identified as risks for celiac disease. Having one or even both of the genes does not ensure that you have or will develop celiac disease. The genetic tests merely establish potential.

Darkside Rookie
3 hours ago, trents said:

We can't tell you anything concerning your IGA test results with the information you have given us. IGA is not a test but a category including several different specific tests. Check this out: https://celiac.org/about-celiac-disease/screening-and-diagnosis/screening/ Can you list the specific tests that were run and the resulting values? We would also need reference ranges to be able to know what is considered normal or negative and what is considered positive. Different labs use different reference ranges.

You have one of the two genes that have been identified as risks for celiac disease. Having one or even both of the genes does not ensure that you have or will develop celiac disease. The genetic tests merely establish potential.

Anti-Transglutaminase (IgA) 57.6 H S1      Reference Range U/mL [0,0-14,9]

Interp.Transglutaminase Positive A S1 R1 

trents Grand Master

Your tTG-IGA at 57.6 is strongly positive. This definitely suggests you have celiac disease. There is another diagnostic step that can be taken and that is an endoscopy with a biopsy of the small bowel lining to check for damage to the villi. This second diagnostic step is considered the gold standard of diagnosing celiac disease. If your physician wants you to have this done it is important to continue to eat regular amounts of gluten (the equivalent of two slices of wheat bread per day) up until the time of the test. You should not go on a gluten free diet until all testing is done in order for the tests to be valid.

If your physician is convinced that you have celiac disease and doesn't see a need for further testing then you need to start eating gluten free. There is a real learning curve involved with that since gluten is hidden by terminology and is often found in foods you would never suspect wheat/barley/rye to show up in. Examples, canned tomato soup and soy sauce and even some chocolate syrup products. This might help: 

 

Scott Adams Grand Master

I agree with @trents, and would only add that you should continue eating gluten until all testing is completed, including the endoscopy if your doctor orders it.

Darkside Rookie

Thank you and to @trents for the advice. 

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    • knitty kitty
      Welcome to the forum, @McKinleyWY, For a genetic test, you don't have to eat gluten, but this will only show if you have the genes necessary for the development of Celiac disease.  It will not show if you have active Celiac disease.   Eating gluten stimulates the production of antibodies against gluten which mistakenly attack our own bodies.  The antibodies are produced in the small intestines.  Three grams of gluten are enough to make you feel sick and ramp up anti-gluten antibody production and inflammation for two years afterwards.  However, TEN grams of gluten or more per day for two weeks is required to stimulate anti-gluten antibodies' production enough so that the anti-gluten antibodies move out of the intestines and into the bloodstream where they can be measured in blood tests.  This level of anti-gluten antibodies also causes measurable damage to the lining of the intestines as seen on biopsy samples taken during an endoscopy (the "gold standard" of Celiac diagnosis).   Since you have been experimenting with whole wheat bread in the past year or so, possibly getting cross contaminated in a mixed household, and your immune system is still so sensitized to gluten consumption, you may want to go ahead with the gluten challenge.   It can take two years absolutely gluten free for the immune system to quit reacting to gluten exposure.   Avoiding gluten most if the time, but then experimenting with whole wheat bread is a great way to keep your body in a state of inflammation and illness.  A diagnosis would help you stop playing Russian roulette with your and your children's health.      
    • trents
      Welcome to the celiac.com community, @McKinleyWY! There currently is no testing for celiac disease that does not require you to have been consuming generous amounts of gluten (at least 10g daily, about the amount in 4-6 slices of wheat bread) for at least two weeks and, to be certain of accurate testing, longer than that. This applies to both phases of testing, the blood antibody tests and the endoscopy with biopsy.  There is the option of genetic testing to see if you have one or both of the two genes known to provide the potential to develop celiac disease. It is not really a diagnostic measure, however, as 30-40% of the general population has one or both of these genes whereas only about 1% of the general population actually develops celiac disease. But genetic testing is valuable as a rule out measure. If you don't have either of the genes, it is highly unlikely that you can have celiac disease. Having said all that, even if you don't have celiac disease you can have NCGS (Non Celiac Gluten Sensitivity) which shares many of the same symptoms as celiac disease but does not involve and autoimmune reaction that damages the lining of the small bowel as does celiac disease. Both conditions call for the complete elimination of gluten from the diet. I hope this brings some clarity to your questions.
    • McKinleyWY
      Hello all, I was diagnosed at the age of 2 as being allergic to yeast.  All my life I have avoided bread and most products containing enriched flour as they  contain yeast (when making the man made vitamins to add back in to the flour).  Within the last year or so, we discovered that even whole wheat products bother me but strangely enough I can eat gluten free bread with yeast and have no reactions.  Obviously, we have come to believe the issue is gluten not yeast.  Times continues to reinforce this as we are transitioning to a gluten free home and family.  I become quite ill when I consume even the smallest amount of gluten. How will my not having consumed breads/yeast/gluten for the better part of decades impact a biopsy or blood work?  I would love to know if it is a gluten intolerance or a genetic issue for family members but unsure of the results given my history of limited gluten intake.   I appreciate the input from those who have gone before me in experience and knowledge. Thank you all!
    • trents
      I know what you mean. When I get glutened I have severe gut cramps and throw up for 2-3 hr. and then have diarrhea for another several hours. Avoid eating out if at all possible. It is the number one source of gluten contamination for us celiacs. When you are forced to eat out at a new restaurant that you are not sure is safe, try to order things that you can be sure will not get cross contaminated like a boiled egg, baked potatos, steamed vegies, fresh fruit. Yes, I know that doesn't sound as appetizing as pizza or a burger and fries but your health is at stake. I also realize that as a 14 year old you don't have a lot of control over where you eat out because you are tagging along with others or adults are paying for it. Do you have support from your parents concerning your need to eat gluten free? Do you believe they have a good understanding of the many places gluten can show up in the food supply?
    • Peace lily
      Okay went online to check green mountain k cups .It was said that the regular coffees are fine but they couldn’t guarantee cross contamination.with the flavors. im trying to figure out since I eliminated the suyrup so far so good. I’m hoping. thanks it feels good to listen to other people there views.
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