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    • knitty kitty
      Toddler recently diagnosed with Type 1 diabetes and need help understanding coeliac screening test results

      By knitty kitty · Posted

      Welcome to the forum, @mytype1diabetes, Your statement that your daughter has become itchy and has hair loss made me think of iron deficiency.  Those were the same symptoms i had when I was iron deficient.  Was she tested for iron deficiency anemia at the time of her diabetes diagnosis?   Seems in the early stages of iron deficiency anemia, blood glucose levels can be falsely elevated.  Treating Vitamin D deficiency can also help immensely.  Vitamin D deficiency, iron deficiency, and deficiencies in the eight B vitamins, especially thiamine, can occur in Celiac disease.  Changes in stool can be caused by iron or thiamine deficiency. I was diagnosed with type two diabetes and had the...
    • Wends
      Toddler recently diagnosed with Type 1 diabetes and need help understanding coeliac screening test results

      By Wends · Posted

       So sorry and sending well wishes. Replying from the UK. The NHS Coeliac Screen test is igAttg (including total igA). Your toddler is unlikely igA deficient with a titer of 22, as a positive test. When the igA anti-tissue transglutaminase antibodies are raised above the reference value or positive, the endomysial test is performed. The TTG test is suggestive of coeliac disease BUT it can be transiently raised in type 1 diabetes, milk protein intolerance (common in early childhood. Can also cause malabsorption similar to coeliac disease). Can be slightly raised in other food sensitivity and food allergy and some other conditions. Whilst it is more specific for coeliac disease than the older...
    • trents
      Toddler recently diagnosed with Type 1 diabetes and need help understanding coeliac screening test results

      By trents · Posted

      Here is an article that gives an overview of all tests that can be used to detect celiac disease:    As you can see, the different tests vary in their degree of specificity and sensitivity. So, it is to be expected that if someone has celiac disease, not all the tests will be positive. Also notice that the tests break down into two large groups, IGA-based tests and IGG-based tests. There is also the EMA (Endomysial Antibodies) which is an older test and has largely been supplanted by he tTG-IGA which is less expensive to administer. So, when you report that the TTG score from your daughter's bloodwork is 22ku/l, we assume you are referring to the tTG-IGA test, which is the most popular test...
    • Scott Adams
      Toddler recently diagnosed with Type 1 diabetes and need help understanding coeliac screening test results

      By Scott Adams · Posted

      I’m so sorry to hear about your toddler’s recent Type 1 diabetes diagnosis, and I understand how overwhelming it must feel to now be navigating possible celiac disease as well. The slightly elevated TTG antibodies (22 ku/L) with normal endomysial antibodies could indicate a few things—sometimes, mild elevations can occur due to factors other than celiac disease, such as recent infections or even Type 1 diabetes itself. However, the symptoms you’ve noticed (changes in stools, itching, and hair thinning) could potentially align with celiac disease, so it’s understandable why you’re concerned. Since the consultant wants to retest in 3–6 months, it may be because they’re assessing whether...
    • mytype1diabetes
      Toddler recently diagnosed with Type 1 diabetes and need help understanding coeliac screening test results

      By mytype1diabetes · Posted

      Hi all, Posting from the UK.  My 2 year old was recently diagnosed with Type 1 diabetes. In the UK they routinely screen for coeliac disease. The test showed slightly elevated levels of TTG antibodies. The consultant wants to repeat these antibodies in 3-6 months time to determine clinical significance. In our letter it said "marginally elevated TTG antibodies (22ku/l), normal endomysial antibodies". I'm not exactly sure what this means, especially given one of the tests were within the normal range, and if we should be worried about the numbers. It is difficult to know if she has any "symptoms" but at the time she was diagnosed with Type 1 diabetes I noticed that her stools had changed. They...
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