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Positive anti-gliadin on gluten-free diet: cross-reactivity??


Lady Rose

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Lady Rose Newbie

Hi there!

I have been gluten-free for most of my life and am extremely careful about contamination. I have a completely gluten-free household including all of my cleaning products, hygiene and beauty products, and even art supplies.

Lately I've been having a nasty autoimmune flare, so I went in for testing. My test results were mostly normal except for two things: SIBO and anti-gliadin IgA. 

I've retraced my every move looking for gluten contamination and can't find any culprits. Does anyone know if cross-reactivity can elevate anti-gliadin IgA levels? Any research or materials you can point me to would be much appreciated!


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Wheatwacked Veteran
3 hours ago, Lady Rose said:

normal except for two things: SIBO and anti-gliadin IgA

"Antigliadin antibodies (AGAs) are antibodies of the IgA and IgG classes found in the serum of celiac disease patients. These antibodies mainly target gliadin-derived peptides, which are the main proteins of gluten. AGAs are not specific for celiac disease as they are also found in patients with other gastrointestinal diseases such as gastritis, gastroenteritis, and IBD."   https://healthmatters.io/understand-blood-test-results/anti-gliadin-iga

SIBO can be What to know about SIBO and its treatment

Low stomach acid from PPI's, not enough fiber to feed the good bacteria, antibiotics kill the good along with the bad bacteria.  Other medications can disrupt the gut. Vitamin and mineral deficiencies. In particular the fortified vitamins in wheat products (E, folic acid, iron) that you are not eating. Most Americans don't eat enough choline and potassium. One study found over 60% of the women of child bearing age they tested were low in iodine. Low Vitamin D is common with autoimmune disease.

Scott Adams Grand Master

This research indicates that in some people cow's milk intolerance can elevate tTG levels:

 

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    • RMJ
      That means the normal range (i.e. not celiac disease) would be a result less than 14.99.  Your result is WAY above that. Some gastroenterologists would diagnose that as celiac disease even without a confirming biopsy because it is more than ten times the top of the normal range.
    • Redanafs
      Hi everyone. Back in 2022 I had blood work drawn for iga ext gliadin. Since then I’ve developed worse stomach issues and all other health issues. My doctor just said cut out gluten. He did no further testing. Please see my test results attached. I just need some direction cause I feel so ill and the stomach pain is becoming worse. Can this test show indications for other gastrointestinal diseases?
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      Clearly from what you've said the info on Dailymed is much more up to date than the other site, which hasn't been updated since 2017. The fact that some companies might be repackaging drugs does not mean the info on the ingredients is not correct.
    • RMJ
      To evaluate the TTG antibody result we’d need to know the normal range for that lab.  Labs don’t all use the same units.  However, based on any normal ranges that I’ve seen and the listed result being greater than a number rather than a specific number, I’d say yes, that is high! Higher than the range where the test can give a quantitative result. You got good advice not to change your diet yet.  If you went gluten free your intestines would start to heal, confusing any further testing,
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