Histamine Intolerance after Gluten Challenge

[knitty kitty]

@Rogol72,

So happy to hear the Thiamine HCL is working for you! 🐱 

Isn't is amazing how quickly the benefits appear!

Benfotiamine will have amazing results, too!

Life Extension, Dr.'s Best and Country Life are brands that are available here in the U.S..  I hope you can find one of those.  Be sure to check the amount of Benfotiamine in each.  Some are 100 mg and some are stronger at 250 mg.  

Work up slowly.  300 - 400 mg of Thiamine HCL is a great place to start.  Adding a Benfotiamine will bring additional benefits.  It does not hurt to take both.

Spread Benfotiamine and Thiamine HCl out over the day, with meals, or about every three hours.  

Do be aware that as our bodies adjust to having plenty of Thiamine, there may be times when you feel worse.  This is the "Thiamine Paradox".  It's our bodies adjusting from coping with very little thiamine to now having plenty.  It feels like we go from weakly battery powered to being powered by a big powerful diesel engine.  Takes a bit of warming up to get our diesel engines running smoothly again.  So don't mind the occasional rough running, it will smooth out.  

Do be sure to take Magnesium Citrate Glycinate which thiamine needs to function properly!

Do take a B Complex supplement.  Remember all the B vitamins work together.  Thiamine needs Riboflavin, Niacin and Pyridoxine and the rest to keep our bodies working properly.  

Keep us posted on your progress!

[Rogol72]

13 hours ago, knitty kitty said:

@Rogol72,

So happy to hear the Thiamine HCL is working for you! 🐱 

Isn't is amazing how quickly the benefits appear!

Benfotiamine will have amazing results, too!

Life Extension, Dr.'s Best and Country Life are brands that are available here in the U.S..  I hope you can find one of those.  Be sure to check the amount of Benfotiamine in each.  Some are 100 mg and some are stronger at 250 mg.  

Work up slowly.  300 - 400 mg of Thiamine HCL is a great place to start.  Adding a Benfotiamine will bring additional benefits.  It does not hurt to take both.

Spread Benfotiamine and Thiamine HCl out over the day, with meals, or about every three hours.  

Do be aware that as our bodies adjust to having plenty of Thiamine, there may be times when you feel worse.  This is the "Thiamine Paradox".  It's our bodies adjusting from coping with very little thiamine to now having plenty.  It feels like we go from weakly battery powered to being powered by a big powerful diesel engine.  Takes a bit of warming up to get our diesel engines running smoothly again.  So don't mind the occasional rough running, it will smooth out.  

Do be sure to take Magnesium Citrate Glycinate which thiamine needs to function properly!

Do take a B Complex supplement.  Remember all the B vitamins work together.  Thiamine needs Riboflavin, Niacin and Pyridoxine and the rest to keep our bodies working properly.  

Keep us posted on your progress!

Thanks. Those brands are available on Amazon.co.uk, though they ship from the US. iHerb.com ship to the EU. I've used Magnesium Malate and Glycinate in the past, Glycinate was more beneficial. I'll try Magnesium Citrate this time around.

[Rogol72]

On 7/14/2022 at 8:00 PM, knitty kitty said:

@Rogol72,

So happy to hear the Thiamine HCL is working for you! 🐱 

Isn't is amazing how quickly the benefits appear!

Benfotiamine will have amazing results, too!

Life Extension, Dr.'s Best and Country Life are brands that are available here in the U.S..  I hope you can find one of those.  Be sure to check the amount of Benfotiamine in each.  Some are 100 mg and some are stronger at 250 mg.  

Work up slowly.  300 - 400 mg of Thiamine HCL is a great place to start.  Adding a Benfotiamine will bring additional benefits.  It does not hurt to take both.

Spread Benfotiamine and Thiamine HCl out over the day, with meals, or about every three hours.  

Do be aware that as our bodies adjust to having plenty of Thiamine, there may be times when you feel worse.  This is the "Thiamine Paradox".  It's our bodies adjusting from coping with very little thiamine to now having plenty.  It feels like we go from weakly battery powered to being powered by a big powerful diesel engine.  Takes a bit of warming up to get our diesel engines running smoothly again.  So don't mind the occasional rough running, it will smooth out.  

Do be sure to take Magnesium Citrate Glycinate which thiamine needs to function properly!

Do take a B Complex supplement.  Remember all the B vitamins work together.  Thiamine needs Riboflavin, Niacin and Pyridoxine and the rest to keep our bodies working properly.  

Keep us posted on your progress!

So is it best to take Thiamine and Magnesium Glycinate at the same time or can they be taken a different times? Magnesium Glycinate at night for example or between meals as it has a relaxing effect!

[knitty kitty]

I take Thiamine at the beginning of meals and magnesium after the meal.  And I do take Magnesium at bedtime with tryptophan (a form of Niacin Vitamin B3 that is required for those feel good neurotransmitters serotonin and dopamine, and helps heal the intestines) and Pyridoxine Vitamin B6 which works with Thiamine to heal the nerves and helps with relaxation.  

[Rogol72]

If anyone is interested, here's an interesting webinar from ITL Health on the importance of Magnesium in relation to food intolerances, histamine etc. ...

www.youtube.com/watch?v=NYeuSw86bzk

 

 

[Rogol72]

On 7/19/2022 at 10:08 AM, knitty kitty said:

I take Thiamine at the beginning of meals and magnesium after the meal.  And I do take Magnesium at bedtime with tryptophan (a form of Niacin Vitamin B3 that is required for those feel good neurotransmitters serotonin and dopamine, and helps heal the intestines) and Pyridoxine Vitamin B6 which works with Thiamine to heal the nerves and helps with relaxation.  

Does anyone have experience of supplementing with Vitamin B5 in terms of dealing with stress and a being a good supplement for the adrenal glands?

Came across this info on the spectracell blog ...

"Also known as pantothenate or pantothenic acid, vitamin B5 is sometimes referred to as the “anti-stress” vitamin because it can reverse some biological damage caused by stress. Physical, emotional, and psychological stresses trigger the adrenal glands to secrete cortisol (a long-term stress hormone) and adrenaline (a short-term stress hormone). Chronic stress drives the production of too much of any of these hormones, which causes damage in the body long after the stress signal has ended. When vitamin B5 is present in adequate amounts, it is able to down-regulate the secretion of cortisol, and the body is able to recover. However, in a deficiency state, the adrenal glands are unable to cope. Under these circumstances, they cannot launch a healthy response against the multiple daily stressors that assail us, and the chronic (often unavoidable) stress eventually takes a physiological toll."

 

[knitty kitty]

@Rogol72,

Pantothetic acid works with Thiamine B1.  

Google "adrenal glands and thiamine".  

Thiamine is needed to down regulate the adrenal response.

 

[Rogol72]

On 7/14/2022 at 8:00 PM, knitty kitty said:

@Rogol72,

So happy to hear the Thiamine HCL is working for you! 🐱 

Isn't is amazing how quickly the benefits appear!

Benfotiamine will have amazing results, too!

Life Extension, Dr.'s Best and Country Life are brands that are available here in the U.S..  I hope you can find one of those.  Be sure to check the amount of Benfotiamine in each.  Some are 100 mg and some are stronger at 250 mg.  

Work up slowly.  300 - 400 mg of Thiamine HCL is a great place to start.  Adding a Benfotiamine will bring additional benefits.  It does not hurt to take both.

Spread Benfotiamine and Thiamine HCl out over the day, with meals, or about every three hours.  

Do be aware that as our bodies adjust to having plenty of Thiamine, there may be times when you feel worse.  This is the "Thiamine Paradox".  It's our bodies adjusting from coping with very little thiamine to now having plenty.  It feels like we go from weakly battery powered to being powered by a big powerful diesel engine.  Takes a bit of warming up to get our diesel engines running smoothly again.  So don't mind the occasional rough running, it will smooth out.  

Do be sure to take Magnesium Citrate Glycinate which thiamine needs to function properly!

Do take a B Complex supplement.  Remember all the B vitamins work together.  Thiamine needs Riboflavin, Niacin and Pyridoxine and the rest to keep our bodies working properly.  

Keep us posted on your progress!

@knitty kitty ... Just curios. What are the additional benefits of Benfotiamine? Do you take choline?

[knitty kitty]

13 hours ago, Rogol72 said:

@knitty kitty ... Just curios. What are the additional benefits of Benfotiamine? Do you take choline?

Benfotiamine helps with intestinal healing along with tryptophan and Theanine.  

Benfotiamine helps with insulin production and sensitivity in Diabetes.  The pancreas uses lots of Thiamine.  Most Diabetics are deficient in Thiamine.  (One of those chicken/egg questions is ... which comes first, thiamine deficiency or diabetes?)  

The common pharmaceutical prescription is Metformin.  Metformin blocks thiamine transporters on cell membranes so that thiamine cannot get inside the cells and causes a functional thiamine deficiency.  Add to that the existing thiamine deficiency, and serious thiamine deficiency symptoms can occur. 

I developed Type Two Diabetes while an undiagnosed Celiac.  I developed Wernicke's Encephalopathy while on Metformin.  My doctors did not recognize thiamine deficiency outside of alcoholism, and wrote me off as "depressed".  Most people with Wernicke's are diagnosed after death.  I was fortunate to have stumbled upon Dr. Derrick Lonsdale and Dr. Chandler Marrs' work....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/

 I now choose to control my blood sugar levels with diet and Benfotiamine.

Allithiamine helps immensely with brain fog and neurological symptoms.  Allithiamine can cross the blood brain barrier by itself.  Benfotiamine needs a carrier, like red blood cells, to cross.  Allithiamine was essential to my recovery.  

Yes, I take choline. It's found in flaxseed oil.  I also eat liver and broccoli, both good sources of choline.  Flaxseed oil helps with the fat soluble forms of thiamine, Allithiamine and Benfotiamine.  The brain is mostly fat and having healthy fats and Omega Threes as in flaxseed oil helps immensely with brain health. 

 

[Posterboy]

14 hours ago, Rogol72 said:

... Just curios. What are the additional benefits of Benfotiamine? Do you take choline?

Rogol72,

One of the main benefits of the Benfotiamine form is it is a Fat Soluble form that has much higher Bioavailability.

https://www.naturalmedicinejournal.com/journal/2018-11/thiamine-deficiency-and-diabetic-polyneuropathy

As the article states it is also helpful with Neuropathy.

Thiamine works best when taken with Magnesium......two well absorbed forms are Magnesium Citrate and Magnesium Glycinate.

Here is a nice article that explains the many ways the body can helped by taking Thiamine but most doctor's have not "Awakened" to this fact.

https://awaken.com/2021/02/the-overlooked-vitamin-that-improves-autoimmune-disease-and-autonomic-dysfunction/

I enjoyed your link on Magnesium and found it to be very helpful!

On 7/23/2022 at 8:56 AM, Rogol72 said:

www.youtube.com/watch?v=NYeuSw86bzk

Here is the link again for anyone following this thread.

https://www.youtube.com/watch?v=NYeuSw86bzk

I hope this is helpful but it is not medical advice.

Posterboy,

[Rogol72]

19 hours ago, knitty kitty said:

Benfotiamine helps with intestinal healing along with tryptophan and Theanine.  

Benfotiamine helps with insulin production and sensitivity in Diabetes.  The pancreas uses lots of Thiamine.  Most Diabetics are deficient in Thiamine.  (One of those chicken/egg questions is ... which comes first, thiamine deficiency or diabetes?)  

The common pharmaceutical prescription is Metformin.  Metformin blocks thiamine transporters on cell membranes so that thiamine cannot get inside the cells and causes a functional thiamine deficiency.  Add to that the existing thiamine deficiency, and serious thiamine deficiency symptoms can occur. 

I developed Type Two Diabetes while an undiagnosed Celiac.  I developed Wernicke's Encephalopathy while on Metformin.  My doctors did not recognize thiamine deficiency outside of alcoholism, and wrote me off as "depressed".  Most people with Wernicke's are diagnosed after death.  I was fortunate to have stumbled upon Dr. Derrick Lonsdale and Dr. Chandler Marrs' work....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/

 I now choose to control my blood sugar levels with diet and Benfotiamine.

Allithiamine helps immensely with brain fog and neurological symptoms.  Allithiamine can cross the blood brain barrier by itself.  Benfotiamine needs a carrier, like red blood cells, to cross.  Allithiamine was essential to my recovery.  

Yes, I take choline. It's found in flaxseed oil.  I also eat liver and broccoli, both good sources of choline.  Flaxseed oil helps with the fat soluble forms of thiamine, Allithiamine and Benfotiamine.  The brain is mostly fat and having healthy fats and Omega Threes as in flaxseed oil helps immensely with brain health. 

 

Very interesting. My thirst for knowledge has led me to learn all the essential nutrients and pathways for neurotransmitter production. Fascinating how the body's systems are interdependent on one another and essential nutrients. I've read that poor blood sugar regulation or insulin response will not allow tyrosine to do it's thing and produce dopamine and the catecholamines. Benfotamine to the rescue!!

[Rogol72]

Update: Thought I'd share this in relation to histamine intolerance and mast cells ... https://link.springer.com/article/10.1007/s40629-021-00171-9  . I've concluded through experimentation and going back through previous blood test results ... that I have a subclinical iron deficiency, as supplementation with a low dose iron complex with vitamin C for the past few days has made a difference in focus and concentration and subsequently less histamine issues. The side effects of Dapsone which I'm trying to come off are not good ... it artificially lowers Ha1C and it's been known to cause anemia at high doses. There are case studies where diabetics on Dapsone therapy had their Ha1C measured in the low 20s and have had to find an alternative. Knowledge is all conquering!!

 

[Posterboy]

On 8/12/2022 at 5:56 AM, Rogol72 said:

Update: Thought I'd share this in relation to histamine intolerance and mast cells ... https://link.springer.com/article/10.1007/s40629-021-00171-9  . I've concluded through experimentation and going back through previous blood test results ... that I have a subclinical iron deficiency, as supplementation with a low dose iron complex with vitamin C for the past few days has made a difference in focus and concentration and subsequently less histamine issues. The side effects of Dapsone which I'm trying to come off are not good ... it artificially lowers Ha1C and it's been known to cause anemia at high doses. There are case studies where diabetics on Dapsone therapy had their Ha1C measured in the low 20s and have had to find an alternative. Knowledge is all conquering!!

 

Rogol72,

You would appreciate this research on Mast Cells and Magnesium.

You Histamine intolerance issues can linked back to Magnesium and Niacin(amide) issues.

Here is the research on it...

http://orthomolecular.org/library/jom/2002/pdf/2002-v17n01-p017.pdf

It shows how the Use of Niacin treats a “Histamine Intolerance”…..

quoting from the PDF

“Using niacin to treat histadelia might seem contradictory considering it will aug[1]ment the release of histamine from basophils and tissue mast cells.11 However, there is evidence that the niacin flush is mediated by the release of prostaglandin D2 (PGD2) from dermal macrophages and not from degranulation of basophil and tis[1]sue mast cells.12,13 Further, Hoffer suggested that daily intake of niacin gradually lowers total body histamine by chronically deplet[1]ing storage levels.1

Niacin has a compli[1]cated mechanism of action that modulates histamine release, lowers total blood hista[1]mine, and increases the production of PGD2….

The Niacinamide form of vitamin B3 (nicotina[1]mide or niacinamide) does not directly pro[1]mote the degranulation of histamine contain[1]ing cells, deplete tissue stores, or increase PGD2 release. Nicotinamide might function primarily by reducing the histaminergic re[1]sponse to antigenic stimulation.”

See this thread to see where Bev in MilW treated her blisters with Niacin...

See also this research that shows how Niacinamide has been shown to treat DH in Celiac's...

https://pubmed.ncbi.nlm.nih.gov/30390734/

See also this thread that shows how Niacin and/or Niacinamide (non-flushing form of Niacin) was used to help the insane itching of DH...

Note: Niacin in higher doses......will cause flushing....but this is a good thing.....when the flushing is done (this will take a week or two) then the itching should get better.

Usually the first flush is the most intense and then it goes down from there....most intense on an empty stomach and will be mitigated (some) when taken with food.

About 20 to 30 minutes later you will notice a flushing.....and each subsequent flush will be less....until it stops flushing a little less with each subsequent dose....until it (flushing) is gone and the itching there after...

I hope this is helpful but it is not medical advice.

2 Timothy 2:7 Consider what I say; and the Lord give thee understanding in all things.

Posterboy by the grace of God,