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Blood work for Celiac Question

Oldie
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Oldie Newbie
Oldie
Posted

New here. Blood work ordered for Celiac showed all normal except for bottom one  which is weak positive. Does this indicate possible celiac disease/gluten sensitivity if all other results in normal range (especially the IGA being normal)? I was eating usual diet, not restricting gluten. 

IMMUNOGLOBULIN A250 mg/dL, in range, 64 - 422 mg/dL

GLIADIN IGA, DEAMIDATED, 7 units 0 - 19 units; Negative 0 - 19
GLIADIN IGG, DEAMIDATED 2 units,; 0 - 19 units; Negative 0 - 19

TRANSGLUTAMINASE IGA, 2U/mL; 0 - 3 U/mL; Negative 0 - 3

THIS ONE: TRANSGLUT IGG, 7 U/mL; 0 - 5 U/mL

Negative 0 - 5
Weak Positive 6 - 9
 

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trents Grand Master
trents
Posted

Possibly, yes. But the results are less than unequivocal for celiac disease. What are your symptoms?

You might ask to have an EMA blood test done. It is not a particularly sensitive celiac disease test but it is pretty definitive if positive for celiac disease.

You may have NCGS (Non Celiac Gluten Sensitiity) instead of celiac disease. They share many of the same symptoms but there is no definitive testing available yet for NCGS. NCGS is 10x more common than celiac disease.

Oldie Newbie
Oldie
Posted
  • Author

Thanks for the quick reply. I have constipation (for years), no diarrhea, but under control, and tight (very tight) band of pain across chest, after eating, just under ribs, almost every day (no other pathology there). In other words, no other typical celiac symptoms. 

trents Grand Master
trents
Posted

Try eating totally gluten free for a few days and see if the pain band across your chest subsides. If it does, you would be warranted in assuming you have a problem with gluten of some kind.

Scott Adams Grand Master
Scott Adams
Posted

This article may be helpful, but I would consider myself a possible celiac if I were you, and, based on your results, your doctor should order an endoscopy to confirm your diagnosis:

Quote

the IgG anti-gliadin antibodies are 91% specific and have an 87% sensitivity. This means that they will show positive results more readily but there is not as strong a correlation with celiac disease. It is less specific. Patients with other conditions but not afflicted with celiac disease will occasionally show positive results. IgG anti-gliadin antibodies are detectable in approximately 21% of patients with other gastrointestinal disorders. This test might yield false positive results but is less likely to yield false negative results.

 

 

Be sure to keep eating gluten daily for 2 weeks before an endoscopy, if your doctor orders this (which would be the normal next step).

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      Thank you for your response! I have considered starting a food diary in the past, I suppose this is as good a time as any to start.  
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