Hashimoto's Cause False Positive?

[AnthonyA333]

I have tpo antibodies and had hashmitos thyroiditis… my tsh t3 and t4 just recently normalized on there own… testing for celiac is

 

Immunoglobulin A, Qn, Serum - 305 normal 

Deamidated Gliadin Abs. IgAU - 5 normal 

Deamidated Gliadin Abs, IgG°: - 2 normal 

t-Transglutaminase (tTG) |gA °2 - <2 normal 

(- Transglutaminase tIG) IgG °2 -    7    Weak positive 

Sed rate and crp normal 

 

could my hashmitos cause this positive of the IGG since my IgA is normal and I am not immonuglbulin deficient 

 

below are genetic results 

 

The patient is positive for DQB1*02, one half of the DQ heterodimer. The Celiac Disease risk from the HLA DQA/DQ genotype is approximately 1:210 0.5%).

This is less than

the 1% risk in the general population.

Allele interpretation for all loci based on IMGT/HL database version 3.49.0

HLA Lab CLIA ID Number 34D0954530

Greater than 95% of celiac patients are positive for either DQ2 or DQ8

(Sollid and Thorsby, (1993) Gastroenterology 105:910-922). However these antigens may also be present in patients who do not have celiac

[Scott Adams]

Yes, it's possible for a weak positive test result for celiac disease (Transglutaminase IgG) to be influenced by other factors, such as positive thyroid peroxidase antibodies (TPO antibodies) and Hashimoto's thyroiditis. Both celiac disease and Hashimoto's thyroiditis are autoimmune conditions, and there can be some overlap in terms of immune system responses and antibody production.

In individuals with autoimmune conditions like Hashimoto's thyroiditis, the immune system can sometimes be more reactive overall, leading to the production of various antibodies. This could potentially result in false-positive or borderline results on tests for other conditions, including celiac disease.

The Transglutaminase IgG test is one of the tests used to diagnose celiac disease. However, its interpretation can be complex, and a single test result may not be definitive. If there are other autoimmune conditions or factors at play, such as Hashimoto's thyroiditis and positive TPO antibodies, they could potentially influence the immune response and lead to a weak positive result on the celiac disease test.

If you have received a weak positive result for celiac disease, it's important to work closely with your healthcare provider to interpret the results in the context of your overall health, medical history, and any other relevant tests. Your doctor might recommend further testing, such as additional celiac-specific antibody tests or even an intestinal biopsy, to clarify the diagnosis.