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Help about genetic test results

cagry
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cagry Newbie
cagry
Posted

Hi everyone. Sorry for my bad english. The test results are like these

DQB1*02     normal

DQA1*05     positive

DQB1*03:02   negative

DQA1*03         negative

What does "DQB1*02   normal" mean ?

Thanks.

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trents Grand Master
trents
Posted
(edited)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482388/

"celiac disease has a multifactorial inheritance, so it does not depend on specific mutations of a single gene but it is caused by a combination of environmental factors and variations in multiple genes [18,19]."

To answer your question, I think "normal" means it is not a variant of that gene associated wit the development of celiac disease. I think "positive" would mean you have a gene or a variant of it associated with celiac disease and negative would mean you don't have that gene or a variant of it at all? Believe me when I say that I am far from being an expert in this field. Hopefully, someone on the forum who is knowledgeable in this area will join in.

Edited by trents
Scott Adams Grand Master
Scott Adams
Posted

I agree with @trents, but be sure to ask your doctor what it means so you can be sure. 

Since you did genetic tests for celiac disease have you also had blood tests done for it?

cagry Newbie
cagry
Posted
  • Author

I haven't had a blood test yet, but I will have it done as soon as possible.

trents Grand Master
trents
Posted

You are not already cutting back on gluten are you? You should be eating normal, even generous amounts of gluten for weeks before the blood test and also before the biopsy if that is ordered as a follow-up to the blood testing.

cagry Newbie
cagry
Posted
  • Author

I'm eating more gluten than usual before the test.

knitty kitty Grand Master
knitty kitty
Posted

I found this article very interesting...

Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109277/

Not a doctor.

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