Help about genetic test results

[cagry]

Hi everyone. Sorry for my bad english. The test results are like these

DQB1*02     normal

DQA1*05     positive

DQB1*03:02   negative

DQA1*03         negative

What does "DQB1*02   normal" mean ?

Thanks.

[trents]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482388/

"celiac disease has a multifactorial inheritance, so it does not depend on specific mutations of a single gene but it is caused by a combination of environmental factors and variations in multiple genes [18,19]."

To answer your question, I think "normal" means it is not a variant of that gene associated wit the development of celiac disease. I think "positive" would mean you have a gene or a variant of it associated with celiac disease and negative would mean you don't have that gene or a variant of it at all? Believe me when I say that I am far from being an expert in this field. Hopefully, someone on the forum who is knowledgeable in this area will join in.

Edited October 3, 2024 by trents

[Scott Adams]

I agree with @trents, but be sure to ask your doctor what it means so you can be sure. 

Since you did genetic tests for celiac disease have you also had blood tests done for it?

[cagry]

I haven't had a blood test yet, but I will have it done as soon as possible.

[trents]

You are not already cutting back on gluten are you? You should be eating normal, even generous amounts of gluten for weeks before the blood test and also before the biopsy if that is ordered as a follow-up to the blood testing.

[cagry]

I'm eating more gluten than usual before the test.

[knitty kitty]

I found this article very interesting...

Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109277/

Not a doctor.