Type 1 diabetes (4year old) and positieve ttg

[marinke]

My daughter (4 years old) has type 1 diabetes since she was 1. Therefore, every year a screening is done. We live in the Netherlands. Every year the screening was fine. This year here ttg is positive, 14, >7 is positive. IGA was in range. Could the diabetes cause this positive result? Or the fact that she was sick the weeks before the brood test?

[trents]

Welcome to the forum, @marinke!

"Type 1a diabetes (DM1) is associated with an increased risk of celiac disease (celiac disease) (1)." from: https://diabetesjournals.org/care/article/35/10/2083/38503/IgA-Anti-transglutaminase-Autoantibodies-at-Type-1

"The prevalence of celiac disease (celiac disease) in children with type 1 diabetes (T1D) is 5.1%, and it is often asymptomatic (1)." from: https://diabetesjournals.org/care/article/48/2/e13/157637/Diagnostic-Outcomes-of-Elevated-Transglutaminase

So, this is 5x the rate found in the general population.

[Scott Adams]

Here is a category of study summaries on the relationship of Type 1 diabetes and celiac disease:

https://www.celiac.com/celiac-disease/celiac-disease-amp-related-diseases-and-disorders/diabetes-and-celiac-disease/

This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. One test that always needs to be done is the IgA Levels/Deficiency Test (often called "Total IGA") because some people are naturally IGA deficient, and if this is the case, then certain blood tests for celiac disease might be false-negative, and other types of tests need to be done to make an accurate diagnosis. The article includes the "Mayo Clinic Protocol," which is the best overall protocol for results to be ~98% accurate.