Test results

[Joyes]

Can you please educate me regarding my recent test results. Ive been gluten free for years. Recent deamidated gliadin Abs, IgA result is 0.9/‘not detected’ but deamidated gliadin Abs, IgG is 26.6/abnormal high. (Normal range is <15.0) So…what can this indicate? 

[Scott Adams]

Your recent test results show an interesting pattern that may warrant further investigation. While your deamidated gliadin Abs, IgA result is within the normal range (0.9, labeled as "not detected"), your deamidated gliadin Abs, IgG is significantly elevated at 26.6, which is above the normal threshold of <15.0. This discrepancy could suggest a few possibilities. Since you've been gluten-free for years, the elevated IgG levels might indicate occasional or inadvertent gluten exposure, as IgG antibodies can remain elevated longer than IgA. Alternatively, it could point to a lingering immune response from prior gluten consumption, even if you’ve been strictly gluten-free. However, it’s also important to consider that elevated IgG alone, without corresponding IgA elevation or other markers like tissue transglutaminase (tTG) antibodies, may not definitively indicate active celiac disease. I would recommend discussing these results with your healthcare provider, who may suggest further testing or a review of your diet to ensure complete gluten avoidance and rule out other potential causes for the elevated IgG levels.

If you eat outside your home, especially at restaurants--even those with gluten-free items or menus--it's probable that you are getting some contamination.

[Joyes]

Interesting for sure. Have you heard of potential cross reactivity to casein (dairy), corn, milket, iats, rice, and yeast?

[Scott Adams]

For someone with celiac disease who might have extreme villi damage the term "cross-reactivity" gets thrown around a lot. 

Many people with celiac disease, especially those who are in the 0-2 year range of their recovery, have additional food intolerance issues which could be temporary. To figure this out you may need to keep a food diary and do an elimination diet over a few months.

Some common food intolerance issues are dairy/casein, eggs, corn, oats, and soy. The good news is that after your gut heals (for most people who are 100% gluten-free this will take several months to two years) you may be able to slowly add some these items back into your diet after the damaged villi heal.

[Levi]

On 3/5/2025 at 12:10 PM, Joyes said:

Can you please educate me regarding my recent test results. Ive been gluten free for years. Recent deamidated gliadin Abs, IgA result is 0.9/‘not detected’ but deamidated gliadin Abs, IgG is 26.6/abnormal high. (Normal range is <15.0) So…what can this indicate? 

Search “deamidated gliadin Abs, IgG is 26.6/abnormal high” online for articles on your exact question above, and I’m sure this forum has an expert in explaining your test results as well. 

[Scott Adams]

This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease.