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Accurate Endoscopy Results?


Hoosiergirl

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Hoosiergirl Newbie

I started to suspect that I might be celiac in mid-February and tried to cut out gluten as much as I could. I took a blood test in mid-March after overloading on gluten for one day (after being off it for about a month). The gluten specific test came back normal (IgA-3) but the gluten sensitive came back positive (IgG-24). My doctor wasn't convinced that gluten was causing my symptoms so he ordered some stool sample tests which all came back normal. I just met with a GI doc this week so I could schedule an endoscopy. The procedure is scheduled for two weeks from today. The doc instructed me to have a full gluten diet for the next two weeks so that they could get accurate results. Is this enough time? Or more than likely will my results come back normal since I haven't been consuming very much gluten for the last 2 months? Should I postpone the endoscopy for another week or more?

Thanks for your input!

Sheri


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jerseyangel Proficient
I started to suspect that I might be celiac in mid-February and tried to cut out gluten as much as I could. I took a blood test in mid-March after overloading on gluten for one day (after being off it for about a month). The gluten specific test came back normal (IgA-3) but the gluten sensitive came back positive (IgG-24). My doctor wasn't convinced that gluten was causing my symptoms so he ordered some stool sample tests which all came back normal. I just met with a GI doc this week so I could schedule an endoscopy. The procedure is scheduled for two weeks from today. The doc instructed me to have a full gluten diet for the next two weeks so that they could get accurate results. Is this enough time? Or more than likely will my results come back normal since I haven't been consuming very much gluten for the last 2 months? Should I postpone the endoscopy for another week or more?

Thanks for your input!

Sheri

Hi Sheri--welcome! Two weeks really isn't enough time to be back on gluten after going off for a while. It takes more like 3 months of eating gluten every day. The stool tests that doctors do won't tell you a thing about Celiac. Since you had a positive blood result, if you don't feel you need the biopsy, you could just go gluten-free now. Of course, that's your call. Remember that a biopsy can rule Celiac in, but it can not rule it out. Best of luck with whatever you deceide to do! :)

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    • par18
      Thanks for the reply. 
    • Scott Adams
      What you’re describing is actually very common, and unfortunately the timing of the biopsy likely explains the confusion. Yes, it is absolutely possible for the small intestine to heal enough in three months on a strict gluten-free diet to produce a normal or near-normal biopsy, especially when damage was mild to begin with. In contrast, celiac antibodies can stay elevated for many months or even years after gluten removal, so persistently high antibody levels alongside the celiac genes and clear nutrient deficiencies strongly point to celiac disease, even if you don’t feel symptoms. Many people with celiac are asymptomatic but still develop iron and vitamin deficiencies and silent intestinal damage. The lack of immediate symptoms makes it harder emotionally, but it doesn’t mean gluten isn’t harming you. Most specialists would consider this a case of celiac disease with a false-negative biopsy due to early healing rather than “something else,” and staying consistently gluten-free is what protects you long-term—even when your body doesn’t protest right away.
    • Scott Adams
      Yes, I meant if you had celiac disease but went gluten-free before screening, your results would end up false-negative. As @trents mentioned, this can also happen when a total IGA test isn't done.
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