Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.


  • Celiac.com Sponsor (A1):
    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Dq8 - Results?

JodiC

Recommended Posts

JodiC Apprentice
JodiC
Posted

I was just wondering if any of you knew why just having the DQ8 gene is so rare? My doc said that you normally see DQ2 along with it but I only have the one. Does anyone know the significance of this and what it could mean for my sons? I have 2 that are displaying classic celiac symptoms. Although one of them keeps having green and black stools. (food dyes have not been ingested). Should I get the dna tested on them? Any help would be greatly appreciated.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


AndreaB Contributor
AndreaB
Posted

I don't know. DQ2 and/or DQ8 predispose to gluten sensitivity/intolerance. Out of the four of us in my family tested, one has DQ8, one has DQ2 & DQ8, one has two DQ2, and one has one DQ2. From enterolab DQ2 or DQ8 are celiac genes but they don't go into just the 8 being rare alone. If you only have the one celiac gene than you're offspring has a 50% chance of that gene being passed on to them. My daughter has the DQ8 and my son has both DQ2. She also has a gene that predisposes to gluten sensitivity, so one of each. I'll be curious to see what combo my baby has. We will get him tested when we scrape the funds together. We know he'll have at least one celiac gene. The following is what enterolab had to say about my daughter.

Interpretation Of HLA-DQ Testing: HLA gene analysis reveals that you have one of the main genes that predisposes to gluten sensitivity and celiac sprue, HLA-DQ2 or HLA-DQ8. Each of your offspring has a 50% chance of receiving this gene from you, and at least one of your parents passed it to you. You also have a non-celiac gene predisposing to gluten sensitivity (DQ1 or DQ3 not subtype 8). Having one celiac gene and one gluten sensitive gene, means that each of your parents, and all of your children (if you have them) will possess at least one copy of a gluten sensitive gene. Having two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe.

Rachel--24 Collaborator
Rachel--24
Posted

I dont recall ever hearing or reading that DQ8 is rare without DQ2. :unsure: I think lots of people here have DQ8 by itself.

JodiC Apprentice
JodiC
Posted
  • Author

I googled DQ8 and found that only 5 to 10% possess that gene. Maybe it means the symptoms are more disturbing to life since almost everyone who messages here has it.

  • 3 weeks later...
mamaw Community Regular
mamaw
Posted

I never heard anyting rare about having only the DQ8 either. My grandson has it and the doctors at children's hospital in Pittsburgh never made any comment.

  • 3 weeks later...
lisamombo Newbie
lisamombo
Posted

I haven't heard much about this lab, but we used the Kimball Genetics Lab. My son has 1/2 of the DQ2 allele and they claim that it is possible for him to have celiac even with only half---but rare.

Anyone know any more?

Lisa M.

mle-ii Explorer
mle-ii
Posted

I only have DQ8 not DQ2. I also have a gluten sensitivity gene.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


daffadilly Apprentice
daffadilly
Posted

Do not be misled into thinking that DQ1 is "only" a gluten sensitive gene. It is as bad or worse than DQ2 or DQ8. If you read the book Dangerous Grains it goes into the gluten sensitivity and really portrays it as worse than celiac as it the umbrella that celiac disease is under.

re the son that has DQ8 & symptoms, I would bet that he also has one DQ1.

There are only two labs in the U.S. that test for DQ1, enterolab.com is one & I do not know the other one.

Rachel--24 Collaborator
Rachel--24
Posted
Do not be misled into thinking that DQ1 is "only" a gluten sensitive gene. It is as bad or worse than DQ2 or DQ8. If you read the book Dangerous Grains it goes into the gluten sensitivity and really portrays it as worse than celiac as it the umbrella that celiac disease is under.

re the son that has DQ8 & symptoms, I would bet that he also has one DQ1.

There are only two labs in the U.S. that test for DQ1, enterolab.com is one & I do not know the other one.

I have DQ1...I also have alot of damage....malabsorption was almost severe and I'm still suffering multiple intolerances. I've heard that this is a very bad gene with regards to gluten sensitivity. I dont have either DQ2 or DQ8....no Celiac genes. Along with the DQ1 I have DQ3. I've read Dangerous Grains...however, I dont recall mention of the DQ1 gene.

I'd like to know where I might find some articles on DQ1....particularly with regards to severity of symptoms. The Braintalk board was a good resource but I'm hearing its closed now. Are you from that board?

daffadilly Apprentice
daffadilly
Posted

Hi Rachel, yes I am from that board, geez, are they not going to get it going again? That would be a shame if they do not. If they do not, they need to move their posts to the list serv.

There were a lot of us DQ1 people on there. I have read that board everyday for the past 2 years. I am in withdrawal :blink:

& yes, DQ1 comes with the potential for a lot of damage. I was under the impression that DQ3 is a celiac gene. Also there are a couple of celiac genes that they know are out there because of people that have a biopsy diagnoses but do not have DQ1, DQ2, DQ8 or DQ3

Unfortunately I lost my hard drive early this year & I lost all my links :angry:

You could start a DQ1 thread, if there is not one already. I have not learned how to search on here etc.

I have a lot of intolerances "allergies" myself, it is worse than the no gluten, which is no problem for me because I was severely "allergic" to barley & oats since I was 25 (& that was a long time ago :lol: ) Which meant that I could not eat any wheat thing that was bought because everything has barley malt in it & I mean everything, I made my own bread etc. Then 12 years ago I met a woman that had celiac & was gluten-free & migrain free, she told me if I would quit eating wheat that my other food allergies would get better. well I resisted for awhile, but I was getting desperate ( had a bladder infection every month & was living on antibiotics) so thinking allergies, I went mostly wheat free (I was already oat & barley free). I would go to my sons house every few months & cheat - get sick, thinking allergy I would go back on my regular diet., Did this over & over for 10 years, until 2 years ago, when I was looking up Hemochromatosis. which runs in the Irish side of our family, I had just found out from a relative that we had found. From Hemochromatosis I got to celiac & what an eye opener that was. I knew I had celiac & could pick it out in my grandchildren & my family & my mother that I now know had mental issues & she died from stomach or intestinal cancer.

I have a 10 year old grandson that also has two DQ1 genes, one from my son & one from my d-i-l- who has dyslexia & her mom has IBS, osteoporosis, & a ton of other celiac symptoms - but I am the only one on the gluten-free diet. My son has had it since he was a baby but is in total denial & took his kids off the gluten-free diet after I had them on it for 6 months, well mostly - he would take them to the movies & feed them hotdogs :huh:

well this has gotten long, that is about all of my "story".

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. Wheatwacked
      - Wheatwacked replied to Scott Adams's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      50

      Supplements for those Diagnosed with Celiac Disease

      Raising you vitamin D will increase absorption of calcium automatically without supplementation of calcium. A high PTH can be caused by low D causing poor calcium absorption; not insuffient calcium intake. With low D your body is not absorbing calcium from your food so it steals it from your bones. Heart has priority over bone. I've been taking 1...
    2. knitty kitty
      - knitty kitty replied to catnapt's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      results from 13 day gluten challenge - does this mean I can't have celiac?

      @catnapt, Wheat germ has very little gluten in it. Gluten is the carbohydrate storage protein, what the flour is made from, the fluffy part. Just like with beans, there's the baby plant that will germinate ("germ"-inate) if sprouted, and the bean part is the carbohydrate storage protein. Wheat germ is the baby plant inside a kernel of wheat...
    3. knitty kitty
      - knitty kitty replied to Scott Adams's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      50

      Supplements for those Diagnosed with Celiac Disease

      Hello, @asaT, I'm curious to know whether you are taking other B vitamins like Thiamine B1 and Niacin B3. Malabsorption in Celiac disease affects all the water soluble B vitamins and Vitamin C. Thiamine and Niacin are required to produce energy for all the homocysteine lowering reactions provided by Folate, Cobalamine and Pyridoxine. Weight...
    4. Florence Lillian
      - Florence Lillian replied to Jane02's topic in Gluten-Free Foods, Products, Shopping & Medications
      11

      Desperately need a vitamin D supplement. I've reacted to most brands I've tried.

      Hi Jane: You may want to try the D3 I now take. I have reactions to fillers and many additives. Sports Research, it is based in the USA and I have had no bad reactions with this brand. The D3 does have coconut oil but it is non GMO, it is Gluten free, Soy free, Soybean free and Safflower oil free. I have a cupboard full of supplements that did not agree...
    5. catnapt
      - catnapt replied to catnapt's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      results from 13 day gluten challenge - does this mean I can't have celiac?

      highly unlikely NOTHING and I mean NOTHING else has ever caused me these kinds of symptoms I have no problem with dates, they are a large part of my diet In fact, I eat a very high fiber, very high vegetable and bean diet and have for many years now. It's considered a whole foods plant based or plant forward diet (I do now eat some lean...
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      133,356
    • Most Online (within 30 mins)
      7,748
    JAGAPG
    Newest Member
    JAGAPG
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.6k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • Wheatwacked
      Supplements for those Diagnosed with Celiac Disease

      By Wheatwacked · Posted

      Raising you vitamin D will increase absorption of calcium automatically without supplementation of calcium.  A high PTH can be caused by low D causing poor calcium absorption; not insuffient calcium intake.  With low D your body is not absorbing calcium from your food so it steals it from your bones.  Heart has priority over bone. I've been taking 10,000 IU D3 a day since 2015.  My doctor says to continue. To fix my lactose intolerance, lots of lactobacillus from yogurts, and brine fermented pickles and saurkraut and olives.  We lose much of our ability to make lactase endogenosly with maturity but a healthy colony of lactobacillus in our gut excretes lactase in exchange for room and board. The milk protein in grass fed milk does not bother me. It tastes like the milk I grew up on.  If I drink commercial milk I get heartburn at night. Some experts estimate that 90% of us do not eat Adequite Intake of choline.  Beef and eggs are the principle source. Iodine deficiency is a growing concern.  I take 600 mcg a day of Liquid Iodine.  It and NAC have accelerated my healing all over.  Virtually blind in my right eye after starting antihypertensive medication and vision is slowly coming back.  I had to cut out starches because they drove my glucose up into the 200+ range.  I replaced them with Red Bull for the glucose intake with the vitamins, minerals and Taurine needed to process through the mitochodria Krebs Cycle to create ATP.  Went from A1c 13 down to 7.9.  Work in progress. Also take B1,B2,B3,B5,B6. Liquid Iodine, Phosphatidyl Choline, Q10, Selenium, D and DHEA.     Choline supplemented as phosphatidylcholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men +    
    • knitty kitty
      results from 13 day gluten challenge - does this mean I can't have celiac?

      By knitty kitty · Posted

      @catnapt, Wheat germ has very little gluten in it.  Gluten is  the carbohydrate storage protein, what the flour is made from, the fluffy part.  Just like with beans, there's the baby plant that will germinate  ("germ"-inate) if sprouted, and the bean part is the carbohydrate storage protein.   Wheat germ is the baby plant inside a kernel of wheat, and bran is the protective covering of the kernel.   Little to no gluten there.   Large amounts of lectins are in wheat germ and can cause digestive upsets, but not enough Gluten to provoke antibody production in the small intestines. Luckily you still have time to do a proper gluten challenge (10 grams of gluten per day for a minimum of two weeks) before your next appointment when you can be retested.    
    • knitty kitty
      Supplements for those Diagnosed with Celiac Disease

      By knitty kitty · Posted

      Hello, @asaT, I'm curious to know whether you are taking other B vitamins like Thiamine B1 and Niacin B3.  Malabsorption in Celiac disease affects all the water soluble B vitamins and Vitamin C.  Thiamine and Niacin are required to produce energy for all the homocysteine lowering reactions provided by Folate, Cobalamine and Pyridoxine.   Weight gain with a voracious appetite is something I experienced while malnourished.  It's symptomatic of Thiamine B1 deficiency.   Conversely, some people with thiamine deficiency lose their appetite altogether, and suffer from anorexia.  At different periods on my lifelong journey, I suffered this, too.   When the body doesn't have sufficient thiamine to turn food, especially carbohydrates, into energy (for growth and repair), the body rations what little thiamine it has available, and turns the carbs into fat, and stores it mostly in the abdomen.  Consuming a high carbohydrate diet requires additional thiamine to process the carbs into energy.  Simple carbohydrates (sugar, white rice, etc.) don't contain thiamine, so the body easily depletes its stores of Thiamine processing the carbs into fat.  The digestive system communicates with the brain to keep eating in order to consume more thiamine and other nutrients it's not absorbing.   One can have a subclinical thiamine insufficiency for years.  A twenty percent increase in dietary thiamine causes an eighty percent increase in brain function, so the symptoms can wax and wane mysteriously.  Symptoms of Thiamine insufficiency include stunted growth, chronic fatigue, and Gastrointestinal Beriberi (diarrhea, abdominal pain), heart attack, Alzheimer's, stroke, and cancer.   Thiamine improves bone turnover.  Thiamine insufficiency can also affect the thyroid.  The thyroid is important in bone metabolism.  The thyroid also influences hormones, like estrogen and progesterone, and menopause.  Vitamin D, at optimal levels, can act as a hormone and can influence the thyroid, as well as being important to bone health, and regulating the immune system.  Vitamin A is important to bone health, too, and is necessary for intestinal health, as well.   I don't do dairy because I react to Casein, the protein in dairy that resembles gluten and causes a reaction the same as if I'd been exposed to gluten, including high tTg IgA.  I found adding mineral water containing calcium and other minerals helpful in increasing my calcium intake.   Malabsorption of Celiac affects all the vitamins and minerals.  I do hope you'll talk to your doctor and dietician about supplementing all eight B vitamins and the four fat soluble vitamins because they all work together interconnectedly.  
    • Florence Lillian
      Desperately need a vitamin D supplement. I've reacted to most brands I've tried.

      By Florence Lillian · Posted

      Hi Jane: You may want to try the D3 I now take. I have reactions to fillers and many additives. Sports Research, it is based in the USA and I have had no bad reactions with this brand. The D3 does have coconut oil but it is non GMO, it is Gluten free, Soy free, Soybean free and Safflower oil free.  I have a cupboard full of supplements that did not agree with me -  I just keep trying and have finally settled on Sports Research. I take NAKA Women's Multi full spectrum, and have not felt sick after taking 2 capsules per day -  it is a Canadian company. I buy both from Amazon. I wish you well in your searching, I know how discouraging it all is. Florence.  
    • catnapt
      results from 13 day gluten challenge - does this mean I can't have celiac?

      By catnapt · Posted

      highly unlikely  NOTHING and I mean NOTHING else has ever caused me these kinds of symptoms I have no problem with dates, they are a large part of my diet In fact, I eat a very high fiber, very high vegetable and bean diet and have for many years now. It's considered a whole foods plant based or plant forward diet (I do now eat some lean ground turkey but not much) I was off dairy for years but recently had to add back plain yogurt to meet calcium needs that I am not allowed to get from supplements (I have not had any problem with the yogurt)   I eat almost no processed foods. I don't eat out. almost everything I eat, I cook myself I am going to keep a food diary but to be honest, I already know that it's wheat products and also barley that are the problem, which is why I gradually stopped eating and buying them. When I was eating them, like back in early 2024, when I was in the middle of moving and ate out (always had bread or toast or rolls or a sub or pizza) I felt terrible but at that time was so busy and exhausted that I never stopped to think it was the food. Once I was in my new place, I continued to have bread from time to time and had such horrible joint pain that I was preparing for 2 total knee replacements as well as one hip! The surgery could not go forward as I was (and still am) actively losing calcium from my bones. That problem has yet to be properly diagnosed and treated   anyway over time I realized that I felt better when I stopped eating bread. Back at least 3 yrs ago I noticed that regular pasta made me sick so I switched to brown rice pasta and even though it costs a lot more, I really like it.   so gradually I just stopped buying and eating foods with gluten. I stopped getting raisin bran when I was constipated because it made me bloated and it didn't help the constipation any more (used to be a sure bet that it would in the past)   I made cookies and brownies using beans and rolled oats and dates and tahini and I LOVE them and have zero issues eating those I eat 1 or more cans of beans per day easily can eat a pound of broccoli - no problem! Brussels sprouts the same thing.   so yeh it's bread and related foods that are clearly the problem  there is zero doubt in my mind    
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.