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Can Celiac Cause Severe Neurological Problems?


imagine22

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imagine22 Contributor

Hi, not to discount the very important and serious neurological problems i have briefly seen on this board caused by celia, but im wondering if celiac can cause severe depression and anxiety.

I have celiac and no problems apart from fatigue and a bit of 'brain fog' but my brother has had severe depression and anxiety problems since he was a small child and has been in and out of hospital for them for years. I was just wondering if celiac can cause that type of extreme neurological problems? he has not been tested as yet (he isnt the most compliant of people!).


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Electra Enthusiast

In my opinion YES it can!! I have develeped several phobias, and avoidance personality disorder and even some paranoid personality disorder because of my Celiac. I can't say that for sure, but now that I look back it all makes sence. One of the major symptoms of Celiac is IRRITABILITY (to the point of mood changes and behavioral changes) that tells me that most of my phobias are a result of fears from having an attack!! I also have a sleep disorder and am now wondering if I aquired that as a result of my Celiac Disease. If I go gluten free and feel better could I possibly end up with no sleep disorder? Interesting question don't you think ;-)!!

Ursa Major Collaborator

Yes, especially the type of gluten intolerance that doesn't cause the villi to flatten (and doctors often won't take you serious if you don't have obvious gut damage) will cause neurological damage instead. It has been proven many times over that celiac disease can cause depression, anxiety, mood changes, autism, ADHD, learning disabilities and even schizophrenia (just to name a few of the many problems gluten can cause).

daffadilly Apprentice

YES, YES, & YES... I was telling a doctor friend recently that I do not think that there is a person that is celiac or gluten sensitive that is not depressed on some level, before going on the gluten-free diet which has helped me a lot... depression is one of the main symptoms along with a lot of other stuff, and a lot of people have no symptoms or only one or two.

Nancym Enthusiast

Check out The Gluten File link in my signature. There's a lot there on neurological disorders, depression and anxiety and gluten sensitivity.

Guest nini

severe depression for years and severe anxiety disorder were just a couple of my symptoms. I kept being sent to psychiatrists who in turn said I didn't need to be there... (counseling didn't do the trick, meds didn't do the trick) the only thing that helped was getting gluten out of my diet and the lifelong battle with depression and anxiety lifted... (I still get it in small doses especially if accidentally glutened but for the most part I'm now depression free)... oh and seizure free too.

jerseyangel Proficient

Definately. I had panic attacks dating back about 20 years. I haven't had one since going gluten-free, but I still have anxiety which is much worse and is coupled with paranoia and moodiness when glutened.


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    • Scott Adams
      This is a very common question, and the most important thing to know is that no, Guinness is not considered safe for individuals with coeliac disease. While it's fascinating to hear anecdotes from other coeliacs who can drink it without immediate issues, this is a risky exception rather than the rule. The core issue is that Guinness is brewed from barley, which contains gluten, and the standard brewing process does not remove the gluten protein to a level safe for coeliacs (below 20ppm). For someone like you who experiences dermatitis herpetiformis, the reaction is particularly significant. DH is triggered by gluten ingestion, even without immediate gastrointestinal symptoms. So, while you may not feel an instant stomach upset, drinking a gluten-containing beer like Guinness could very well provoke a flare-up of your skin condition days later. It would be a gamble with a potentially uncomfortable and long-lasting consequence. Fortunately, there are excellent, certified gluten-free stouts available now that can provide a safe and satisfying alternative without the risk.
    • MogwaiStripe
      Interestingly, this thought occurred to me last night. I did find that there are studies investigating whether vitamin D deficiency can actually trigger celiac disease.  Source: National Institutes of Health https://pmc.ncbi.nlm.nih.gov/articles/PMC7231074/ 
    • Butch68
      Before being diagnosed coeliac I used to love Guinness. Being made from barley it should be something a coeliac shouldn’t drink. But taking to another coeliac and they can drink it with no ill effects and have heard of others who can drink it too.  is this everyone’s experience?  Can I drink it?  I get dermatitis herpetiformis and don’t get instant reactions to gluten so can’t try it to see for myself. 
    • trents
      NCGS does not cause damage to the small bowel villi so, if indeed you were not skimping on gluten when you had the antibody blood testing done, it is likely you have celiac disease.
    • Scott Adams
      I will assume you did the gluten challenge properly and were eating a lot of gluten daily for 6-8 weeks before your test, but if not, that could be the issue. You can still have celiac disease with negative blood test results, although it's not as common:  Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606118/  Seronegative Celiac Disease - A Challenging Case: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441776/  Enteropathies with villous atrophy but negative coeliac serology in adults: current issues: https://pubmed.ncbi.nlm.nih.gov/34764141/  Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.
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