Jump to content
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

False Positive?


kpyoung24

Recommended Posts

kpyoung24 Rookie

hi everyone its me again! okay so we went to the ped gi today and now more confused than before!! my daughter's test was a transglutaminase IgG test which she said is not as reliable as the transglutaminase IgA test, so first of all what's the difference between the two? also, she said that since it was a weak positive it might be a false positive.. so we are going to go ahead with the biopsy. but I've been hearing and reading that there is no such thing as a false positive, so what gives??? I'm totally conflicted now! can anyone help please!?!? Thanks!~K


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



elye Community Regular

I can answer your second question: with these tests, there are no false positives, only false negatives. If they find the antibodies, then you have the condition. A "weak" positive sounds odd, as it's like being a little pregnant--either you are or you aren't. Perhaps they found only a small count on the antibodies, but they're still there, and it proves an intolerance at the very least.

mamaw Community Regular

Yes, it is very rare but there can be false positive. That is what my readings were in the beginning. And one of the big celiac doctors agreed it happens, rarely but it happens. I asked that question while at a conference...

hth

mamaw

kpyoung24 Rookie

thanks for the replies! any info helps! this is all so overwhelming...i'm just ready for them to diagnose her so that we can get her feeling better. she's always nauseated, has chronic (very foul smelling) diarrhea,gas, bloating, tummy aches, fatigue...etc. its sounds like celiac to me, but it doesn't really matter as long as we can get her better. ugh!!!

healthygirl Contributor

Hi, Yes, my situation is that I got a weak positive on the transglutaminase test and my doctor repeated the same test (not sure why) and the second one came back negative. I have an appointment with her in a couple of days to find out why we don't need a 3rd blood test and why she is assuming the first one is wrong, as she seems to think the second one being negative somehow means nothing is wrong. It's frustrating and I'm thinking I might just stick with gluten-free and not worry about an official diagnosis.

M.

Archived

This topic is now archived and is closed to further replies.

  • Celiac.com Sponsor (A19):
  • Member Statistics

    • Total Members
      133,206
    • Most Online (within 30 mins)
      7,748

    juliemt
    Newest Member
    juliemt
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):
  • Forum Statistics

    • Total Topics
      121.6k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):
  • Upcoming Events

  • Posts

    • Scott Adams
      Celiac disease is the most likely cause, but here are articles about the other possible causes:    
    • xxnonamexx
      Please read: https://www.fda.gov/news-events/press-announcements/fda-takes-steps-improve-gluten-ingredient-disclosure-foods?fbclid=IwY2xjawPeXhJleHRuA2FlbQIxMABicmlkETFzaDc3NWRaYzlJOFJ4R0Fic3J0YwZhcHBfaWQQMjIyMDM5MTc4ODIwMDg5MgABHrwuSsw8Be7VNGOrKKWFVbrjmf59SGht05nIALwnjQ0DoGkDDK1doRBDzeeX_aem_GZcRcbhisMTyFUp3YMUU9Q
    • cristiana
      Hi @Atl222 As @trents points out, there could be many reasons for this biopsy result.  I am interested to know, is your gastroenterologist concerned?  Also, are your blood tests showing steady improvement over the years? I remember when I had my last biopsy, several years after diagnosis, mine came back with with raised lymphocytes but no villous damage, too! In my own case, my consultant wasn't remotely concerned - in fact, he said I might still get this result even if all I ever did was eat nothing but rice and water.   My coeliac blood tests were still steadily improving, albeit slowly, which was reassuring.
    • trents
      Welcome to the celiac.com community, @Atl222! Yes, your increased lymphocytes could be in response to oats or it could possibly be cross contamination from gluten that is getting into your diet from some unexpected source but not enough to damage the villi. And I'm certain that increased lymphocytes can be caused by other things besides celiac disease or gluten/oats exposure. See attachment. But you might try eliminating oats to start with and possibly dairy for a few months and then seek another endoscopy/biopsy to see if there was a reduction in lymphocyte counts. 
    • Scott Adams
      This is a solid, well-reasoned approach. You’re right that “koji” by itself doesn’t indicate gluten status, and the risk really does come down to which grain is used to culture it. The fact that you directly contacted Eden Foods and received a clear statement that their koji is made from rice only, with no wheat or barley, is meaningful due diligence—especially since Eden has a long-standing reputation for transparency. While the lack of gluten labeling can understandably give pause, manufacturer confirmation like this is often what people rely on for traditionally fermented products. As always, trusting your body after trying it is reasonable, but based on the information you gathered, your conclusion makes sense.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.