Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Need Help With Genetic Test Results

wahmmy

Recommended Posts

wahmmy Apprentice
wahmmy
Posted

We did the genetic tests on our two daughters, ages 5 and 2, with Enterolab. We just got the results back and they were the same for both daughters. I'm having trouble interpreting them despite all the info provided from the website link provided. Could you help me? Thanks!

Also, I take this to mean that I have at least one gluten sensitivity gene? My husband is the one with Celiac, diagnosed through blood work and a biopsy a couple of months ago. His father also has Celiac.

Should we test them further at this point? What about myself?

And the severity issue of immunological response -- does that mean that lymphoma and some of those other issues are still a risk even if it's not Celiac? (Because I'm taking it that they won't get Celiac with these results?) What about nutritional deficiencies? Are these not a risk if Celiac damage isn't being done? Is it just they may have bad symptoms but not the actual intermal damage? Sorry for all the questions!

Gluten Sensitivity Gene Test

HLA-DQB1 Molecular analysis, Allele 1 0301

HLA-DQB1 Molecular analysis, Allele 2 0303

Serologic equivalent: HLA-DQ 3,3 (Subtype 7,9)

Interpretation Of HLA-DQ Testing: Although you do not possess the main HLA-DQB1 genes predisposing to celiac sprue (HLA-DQB1*0201 or HLA-DQB1*0302), HLA gene analysis reveals that you have two copies of a gene that predisposes to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having two copies of a gluten sensitive gene means that each of your parents and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity may be more severe.

For more information about result interpretation, please see Open Original Shared Link

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


nora-n Rookie
nora-n
Posted

There are some celiacs here with either of these genes. I think someone even asked about this comination recently.

ShayFL Enthusiast
ShayFL
Posted

Nora is right. There are dx'd Celiacs with this genetic makeup. What are your husbands genes? Since he is dx'd Celiac, if he doesnt have the 2 U.S. recognized Celiac genes, then it is a whole new ballgame for your children.

wahmmy Apprentice
wahmmy
Posted
  • Author
Nora is right. There are dx'd Celiacs with this genetic makeup. What are your husbands genes? Since he is dx'd Celiac, if he doesnt have the 2 U.S. recognized Celiac genes, then it is a whole new ballgame for your children.

His dr. didn't do a genetic test on him. They dx through I guess other blood work and also the biopsy. His numbers were really high in the blood work, but I know they didn't do a genetic test on him. He's going to see about getting it done now so insurance can pay for it and we won't have to do enterolab with him. Since the girls are so young, we felt the genetic test would be best to start with them and if they didn't have anything, it wouldn't be an issue. Enterolab said that was the way to go as well. Now I wish we would have gone ahead and done a full panel on them b/c now it seems we need to.

I'd just like to know about them for sure before we ban it completely for them outside the house. It's going to be a big deal to my oldest regarding school snacks, parties, etc. and I don't want to force her to take special food to those things if it's not an issue for her yet. Otherwise, we are moving toward a gluten-free home and he is completely gluten-free. All meals we eat with him are gluten-free.

nora-n Rookie
nora-n
Posted

If they are on a low gluten diet, the tests probably will be inconclusive. You really have to eat a lo of gluten for a long time for the tests to be very positive for ordinary celiac.

We keep reading about people getting ill after going "healthy" and starting to bake whole wheat bread and eating whole wheat stuff. Also, the Italians have the highest incidence of celiac , they eat a lot of pasta...

The genes only explain half of celiac.

The highest risk is having a family member with celiac disease.....

nora

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      131,612
    • Most Online (within 30 mins)
      7,748
    Rotary
    Newest Member
    Rotary
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • itsdunerie
      Potential celiac need advice

      By itsdunerie · Posted

      Dang......did it again and yeah I should admit I am 63 with clumsy phone thumbs. I started feeling better quickly and a doctor a year later said I had to eat  poison (gluten) every day for a month so he could formally diagnose me and NO FREAKING WAY. I couldn't then and can't imagine putting my body through that crap (no pun intended) on purpose ever again.  Why ingest poison for a month to have some doctor say Hey, All you Have To Do Is Never Eat poison Again.. 
    • itsdunerie
      Potential celiac need advice

      By itsdunerie · Posted

      Poop head, sorry, but I accidentally posted and can't figure out how to continue my post. My long winded post was going to tell you that after I figu
    • itsdunerie
      Potential celiac need advice

      By itsdunerie · Posted

      15 years ago my best friend 'diagnosed' me as Celiac. Her little nephew had been formally diagnosed and her observations of me dealing with brain fog, stomach problems and other stuff had her convincing me to try going gluten free. Oh my heavens, within 3 days, no lie, I felt human again. Took me about a y
    • Scott Adams
      Potential celiac need advice

      By Scott Adams · Posted

      It seems like you have two choices--do a proper gluten challenge and get re-tested, or just go gluten-free because you already know that it is gluten that is causing your symptoms. In order to screen someone for celiac disease they need to be eating gluten daily, a lot of it--they usually recommend at least 2 slices of wheat bread daily for 6-8 weeks before a blood screening, and at least 2 weeks before an endoscopy (a colonoscopy is no used to diagnose celiac disease). Normally the blood panel is your first step, and if you have ANY positive results there for celiac disease the next step would be to take biopsies of your villi via an endoscopy given by a gastroenterologist.  More info on the blood tests and the gluten challenge beforehand is below: The article includes the "Mayo Clinic Protocol," which is the best overall protocol for results to be ~98% accurate. Here is more info about how to do a gluten challenge for a celiac disease blood panel, or for an endoscopy: and this recent study recommends 4-6 slices of wheat bread per day:   Not to discourage you from a formal diagnosis, but once you are diagnosed it may lead to higher life and medical insurance rates (things will be changing quickly in the USA with the ACA starting in 2026), as well as the need to disclose it on job applications. While I do think it's best to know for sure--especially because all of your first degree relatives should also get screened for it--I also want to disclose some negative possibilities around a formal diagnosis that you may want to also consider.  
    • Wheatwacked
      Potential celiac need advice

      By Wheatwacked · Posted

      Yes.  Now, if you hit your finger with a hammer once, wouldn't you do your best not to do it again?  You have identified a direct connection between gluten and pain.  Gluten is your hammer.  Now you have to decide if you need a medical diagnosis.  Some countries have aid benefits tgat you can get if you have the diagnosis, but you must continue eating a gluten-normal diet while pursuing the diagnosis. Otherwise the only reason to continue eating gluten is social. There are over 200 symptoms that could be a result of celiac disease.. Celiac Disease and Non Celiac Gluten Sensitivity  both cause multiple vitamin and mineral deficiency.  Dealing with that should help your recovery, even while eating gluten.  Phosphatidyl Choline supplements can help your gut if digesting fats is a problem,  Consider that any medications you take could be causing some of the symptoms, aside from gluten.        
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.