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Please Help With Results

socalmomto2

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socalmomto2 Newbie
socalmomto2
Posted

Can someone help me with these results... my sons Ped. Is an IDIOT!!! first he tells me I am crazy to even want any test run, then when it comes back he says his IGG is slightly elevated and everything els is fine... UM... IGA is VERY elevated, IGG is neg. and everything else is not fine... his ANA is positive.

My son had chronic diareaha from 9 weeks onld until he was a year old and we took him off formula. he only gained 4 pounds in the 4 1/2 months following birth (born at 8lbs 15 oz) he was put on Isomil DF (it is loaded with fiber) to help him pass a normal stool, but all the fiber took all the nutrients along with it. Now he is 7 and has chronic constipation, horrible bowel movements, and is becoming more and more out of control behavioral wise. To the point where he is seeing a counselor who was looking at Ashbergers (a form of Autism Spectrum Disorder) and Bipolar... (it isn't bipolar) I just don't know what to do... what do these results mean, as the ped won't give me any info on it...

his results are the bold... with the range for each test he had done...

Endomysial Antibody Screen (IGA) with reflex to titer

Negative

TNP-screening test negative. Titer not performed

Tissue Transglutaminase

Antibody, IGA

TTG Antibody, IGA

<3

negative <5

equivocal 5-8

positive >8

Gliadin Antibody

(IGG, IGA)

Gliadin Antibody (IGA)

84

negative <11

equivocal 11-17

positive >17

Gliadin Antibody (IGG)

3

negative <11

equivocal 11-17

positive >17

ANACHOICE Screen

W/ REFL to TITER, IFA

ANACHOICE SCREEN

POSITIVE

AntiNuclear Antibodies

Titer and Pattern

Speckled

AntiNuclear Antibodies

1:80

Reference range

<1:40 Negative

1:40 - 1:79 Low antibody level

>1:80 Elevated antibody level

Immunoglobulin G

798

673 - 1734 mg/dL reference range

So... his Gliadin Antibody IGA is very high, he is ANA positive, and his Immunoglobulin is on the lower end of the range...

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ShayFL Enthusiast
ShayFL
Posted

You dont need a doctor's permission to put him on a gluten-free diet. It is very difficult to get a POS result on children under age 6 when they have ACTIVE Celiac. So getting any POS result is very TELLING. His little body is reacting to gliadin and likely gluten as well. When he is 7 you might very well get a POS for Celiac, but the damage could be horrendous by then. His ANA is elevated which shows inflammation. By age 7 he could have full blown autoimmune disease (Type 1 diabetes being most common in children with Celiac).

You have nothing to lose by trying him on a gluten-free diet and everything to gain at this point. I would nix dairy too until he is all healed. Then try reintroducing dairy to see how he reacts. A lot of people/children have to cut dairy till the tips of their villi heal.

You might also opt for a genetic test to see if you have Celiac genes. It does not dx Celiac, but is another piece to the puzzle. If your doctor says no, you can use Enterolab for genetic testing without a doctor's Rx.

Mother of Jibril Enthusiast
Mother of Jibril
Posted

It's possible that your son does not have celiac disease (at least not yet), but he's definitely having an autoimmune reaction to wheat. You should absolutely get him on a gluten-free diet! Having a positive ANA at such a young age is NOT good. Sometimes people have a positive ANA without any obvious signs of illness, but that's usually in late middle age or older. A "speckled" pattern could indicate lupus (SLE), scleroderma, Sjogren's syndrome, or some other "mixed connective tissue disorder." You really need to find a new pediatrician! Even better, get a referral to a specialist like a rheumatologist... somebody who will be able to order and understand more specific antibody tests.

Kids can heal really fast, but IMO you need to figure out what's going on.

Good for you for asking to have your son tested!!!! And for finding this forum :)

socalmomto2 Newbie
socalmomto2
Posted
  • Author

My son turned 7 in September... I am fighting the peds office for a referal out... I did manage to get a referal to a GI today... should I ask to see a different specialist than a GI???

Mother of Jibril Enthusiast
Mother of Jibril
Posted

Unfortunately, there's no such thing as an "autoimmunologist," so you have to deal with different doctors for different parts of your son's problem.

You could ask a GI about doing an endoscopy to look for damage in your son's intestines... he or she might be able to help resolve the constipation and gluten intolerance issues.

A rheumatologist is the person you want to see about the positive ANA.

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    • Scott Adams
      Test interpretations

      By Scott Adams · Posted

      Based on those results alone, it’s not possible to say you have celiac disease. The test that is usually most specific for celiac, tTG-IgA, is negative in your results, and the endomysial antibody (EMA) is also negative, which generally argues against active celiac disease. However, your deamidated gliadin IgA is elevated, and your total IgA level is also high, which can sometimes affect how the other antibody tests behave. Another important factor is that you were reducing gluten before the test, which can lower antibody levels and make the results less reliable. Because of that, many doctors recommend a gluten challenge (eating gluten regularly for several weeks) before repeating blood tests or considering an endoscopy if symptoms and labs raise concern. It would be best to review these results with a gastroenterologist, who can interpret them in context and decide whether further testing is needed.
    • trents
      Test interpretations

      By trents · Posted

      Since you compromised the validity of the antibody testing by experimenting with gluten withdrawal ahead of the testing, you are faced with two options: 1. Reintroduce significant amounts of gluten into your diet for a period of weeks, i.e., undertake a "gluten challenge". The most recent guidelines are the daily consumption of at least 10g of gluten (about the amount found in 4-6 slices of wheat-based bread) for at least two weeks leading up to the day of testing. Note: I would certainly give it more than two weeks to be sure. 2. Be willing to live with the ambiguity of not knowing whether gluten causes you problems because you have celiac disease or NCGS (Non Celiac Gluten Sensitivity). There is no test for NCGS. Celiac disease must first be ruled out and we have tests for it. Celiac disease has an autoimmune base. NCGS does not. GI symptoms overlap. In the early stages of celiac disease, other body systems may not be showing stress or damage so, symptomatically, it would be difficult to distinguish between celiac disease and NCGS. Both conditions require elimination of gluten from the diet for symptom relief. Some experts feel that NCGS can be a precursor to celiac disease.
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      Hi Kayla Huge sympathies. I was diagnosed in December, after 8 months of the most awful rash, literally top to toe. Mine is a work in progress. Im on just 50mg dapsone at the moment but probably need an increased dose to properly put the lid on it. As you have been now glutened, I wondered whether it might be worth asking for a skin biopsy to finally get a proper diagnosis? Sue  
    • MicG
      Test interpretations

      By MicG · Posted

      I had been eating reduced gluten until about 3 days before the test. I did realize that wasn’t ideal, but it was experimental to see if gluten was actually bothering me. One slip up with soy sauce and it was quite clear to me that it was, lol. 
    • trents
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