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Anti-Gliadin Iga Of 42

sue1234

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sue1234 Rookie
sue1234
Posted

Last November, I went through the labwork for celiac. Everything was normal except the anti-gliadin IgA of 42.

Had an endoscopy and all was "normal". So, told celiac was not my problem.

So, what exactly does a 400% above normal mean with the anti-gliadin IgA?? I think they at least owe me an explanation of why I have a high test result, instead of telling me I'm normal. What else could it mean?

By the way, I am predominantly constipated and AWFUL BLOATING. I have a whole host of other issues, but not sure they are related.

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ravenwoodglass Mentor
ravenwoodglass
Posted

Have you tried the diet and did you get a copy of the endo report? Some doctors won't diagnose celiac unless the villi are totally destroyed and disregard blunting, scalloping and eiosinophils, all of which are indictions of celiac.

If you are done with doctors you should give the diet a good strict try. You may be surprised how much resolves. I know I was.

Skylark Collaborator
Skylark
Posted

Anti-gliadin IgA has a high false positive rate for celiac disease with villous atrophy, and in some people it can appear and disappear. Doctors don't think much of that test alone, with no anti-tTG or anti-EMA and a negative biopsy.

Thing is, you don't have to be celiac with villous atrophy to feel awful when you eat gluten. The anti-gliadin IgA means your immune system recognizes gluten as "foreign". That alone is enough to make it worth giving the diet a try to see if you feel better.

ravenwoodglass Mentor
ravenwoodglass
Posted

Anti-gliadin IgA has a high false positive rate for celiac disease with villous atrophy, and in some people it can appear and disappear. Doctors don't think much of that test alone, with no anti-tTG or anti-EMA and a negative biopsy.

Thing is, you don't have to be celiac with villous atrophy to feel awful when you eat gluten. The anti-gliadin IgA means your immune system recognizes gluten as "foreign". That alone is enough to make it worth giving the diet a try to see if you feel better.

I was under the impression that it was more likely to have a false negative rate, was that what you meant? I thought when someone had a positive anti-gliadin and atrophy that was pretty conclusive as far as celiac is concerned.

Skylark Collaborator
Skylark
Posted

What I'm trying to say is that the anti-gliadin IgA can be positive in non-celiac people who have a normal biopsy. Wouldn't that be a false positive? I'm horribly brain fogged today and can't figure out why. I'm really sorry if I am writing confusing posts.

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