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B12, Pre-Mature Grey, Celiac?


Emma-Lee

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Emma-Lee Rookie

Hello. I was only recently diagnosed with Celiac. As I have been reading many articles here and online I am curious about the relationship between Celiac and grey hair. I have not been tested for vitamin deficiency levels yet, as I was literally just diagnosed. I am meeting with my doctor again in 2 weeks so we can see how I am doing with my new gluten-free diet.

I have had pre-mature grey hair since I was 12, I am 28 now. I have never been tested for vit B-12, and this may very well be hereditary as my father started to grey at around 25. I have read some articles about a link between grey hair and B12. Similarly I have read some on Ceilac and B12 issues. This may not be a mathematical equation "if a=b, and b=c then a=c," but I am curious if anyone can give me feedback about links btwn grey hair and Celiac.

I may be throwing in something off the wall, but am curious as well. I probably will request a B12 test in 2 weeks.

Thanks in advance.


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mommida Enthusiast

There is a link between Celiac and Pernicious anemia (a lack of the intinsic factor in the gut lining to properly absorb vitamin B12).

Emma-Lee Rookie

There is a link between Celiac and Pernicious anemia (a lack of the intinsic factor in the gut lining to properly absorb vitamin B12).

Do I ask my doctor for B12 test or a pernicious anemia test? I am very new to this and have not had 1 test beyond Celiac yet. I am making a list for my doctor. Thanks for the info!

Fire Fairy Enthusiast

I started noticing gray hair at 17. Now at 36 I have a lot silver threads, people think I get my highlights done. :D I used to be upset about it and started dying it at 17 but since I don't know of any gluten free hair dye and I can't afford to have it done in a salon, I'm calling my hair color "recession gray".

Good for you making a list for the Dr. Very good idea.

shopgirl Contributor

I've had little streaks of white hair since I was a teenager too — I'm 27 now. I actually love it and can't wait to have more. I think gray and white hair is gorgeous. But I don't think it has anything to do with Celiac.

But definitely ask your doctor for a complete vitamin panel including the usual suspects like iron, B, and D.

Edited to add: All of my vitamin levels checked out after my diagnosis. My B12 numbers were well within normal range and I still have the silvers. :)

cassP Contributor

i think grey hair is part genetics, part disease link, and possibly diet related too.

i hate to sound like a broken record- but you should get fairly routine Thyroid panels done-> as Thyroid disorders can be common with Gluten Intolerance AND-> can cause premature greying.

ive never heard of B12 def. contributing to grey hair- but i dont know everything.

imho: as a Celiac or Gluten Intolerant: your basic tests you need to be getting are: B12, vit. D, Iron, & Thyroid. these issues seem to be the most common with gluten intolerance. definitely get these done.

im not sure if there's a pernicious anemia test-> or if the doc can just tell by the B12 levels???

rosetapper23 Explorer

See my next post....


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rosetapper23 Explorer

From my past research, I learned that graying of the hair is caused by the depletion of catalase. Unfortunately, simply taking catalase supplements may not do the trick (don't be fooled by the many products on the market that state that taking their catalase supplement will stop the graying process). Depletion of catalase occurs naturally throughout our lifetimes. However, its levels are maintained by specific minerals, and it has been conjectured that if the levels of those minerals are maintained, catalase will also remain high. Those minerals are zinc, manganese, copper and selenium. I can attest to the fact that when I was accidentally glutened last April, one of the symptoms that appeared soon after was hairloss and the sudden growth of many gray hairs. I also appeared to have other symptoms of being deficient in zinc, manganese, and selenium. I supplemented with chelated amino acids forms of zinc and manganese (and I took copper, too, since it's needed if you take zinc supplements), and all of my symptoms improved except the graying. I tried taking selenium from various manufacturers, but couldn't tolerate it at all. I suspect that I'm very low in selenium....but what can I do?

Anyway, perhaps you're able to tolerate all of these minerals--good luck to you! And if fewer gray hairs appear, please share that fact with us here on the Forum.

cassP Contributor

From my past research, I learned that graying of the hair is caused by the depletion of catalase. Unfortunately, simply taking catalase supplements may not do the trick (don't be fooled by the many products on the market that state that taking their catalase supplement will stop the graying process). Depletion of catalase occurs naturally throughout our lifetimes. However, its levels are maintained by specific minerals, and it has been conjectured that if the levels of those minerals are maintained, catalase will also remain high. Those minerals are zinc, manganese, copper and selenium. I can attest to the fact that when I was accidentally glutened last April, one of the symptoms that appeared soon after was hairloss and the sudden growth of many gray hairs. I also appeared to have other symptoms of being deficient in zinc, manganese, and selenium. I supplemented with chelated amino acids forms of zinc and manganese (and I took copper, too, since it's needed if you take zinc supplements), and all of my symptoms improved except the graying. I tried taking selenium from various manufacturers, but couldn't tolerate it at all. I suspect that I'm very low in selenium....but what can I do?

Anyway, perhaps you're able to tolerate all of these minerals--good luck to you! And if fewer gray hairs appear, please share that fact with us here on the Forum.

interesting about the Selenium... as Selenium deficiency often occurs in those with thyroid disorders. i did a ton of research after my Hashi & Grave's dx... and Selenium is the number 1 thing to take to help. instead of taking the supplement- i opted for eating 3 Brazil nuts a day. or 2. its been stressed that you can overdose on selenium very easily and that it can be very dangerous- that is why i only eat 3 maximum a day.

IrishHeart Veteran

Hello. I was only recently diagnosed with Celiac. As I have been reading many articles here and online I am curious about the relationship between Celiac and grey hair. I have not been tested for vitamin deficiency levels yet, as I was literally just diagnosed. I am meeting with my doctor again in 2 weeks so we can see how I am doing with my new gluten-free diet.

I have had pre-mature grey hair since I was 12, I am 28 now. I have never been tested for vit B-12, and this may very well be hereditary as my father started to grey at around 25. I have read some articles about a link between grey hair and B12. Similarly I have read some on Ceilac and B12 issues. This may not be a mathematical equation "if a=b, and b=c then a=c," but I am curious if anyone can give me feedback about links btwn grey hair and Celiac.

I may be throwing in something off the wall, but am curious as well. I probably will request a B12 test in 2 weeks.

Thanks in advance.

My B-12 was tanked and I was going grey by 28. I did not think anything about either of these factors until I got very ill in 2008 (when I was 51) and went downhill for 3 years until I read about the many symptoms of celiac. Now, I can tie a whole slew of health issues/symptoms to celiac disease.

My Dad suffered from anemia his whole life and now, we can tie his other health problems to this disease as well.

You definitely want to have your B-12 level checked and your thyroid levels. But I think we drove that one home to you on your another post about having babies!! :)

Taking a list of questions to your doctor is a great idea!! Being pro-active is the thing that saved me from further decline (meaning I was persistent and wouldn't take being dismissed ) :D and it will serve you well too! Good luck.

rosetapper23 Explorer

Good information on the selenium--thanks! I have Hashimoto's, which I've treated with Armour Thyroid for the past three years. I'll try eating the brazil nuts--as I recall, they're not too hard (have extremely brittle teeth).

cassP Contributor

Good information on the selenium--thanks! I have Hashimoto's, which I've treated with Armour Thyroid for the past three years. I'll try eating the brazil nuts--as I recall, they're not too hard (have extremely brittle teeth).

i only eat up to 3 a day... it's supposed to help lower Hashi & Grave's antibodies. it's also supposed to help you convert your T4 to T3 easier. so far, they have not bothered my teeth.. they're kind of fatty.. i still indulge on Almond M&Ms.. and those almost crack my teeth :huh:

Emma-Lee Rookie

Wow! This information is amazing and has truly sparked an investigation! I will be talking to my doctor about all these issues and requesting labs. I will keep everyone updated. Thanks, thanks, thanks =)

mommida Enthusiast

vitamin and mineral deficiency is commonly overlooked by the medical community. If it weren't for your post I wouldn't have searched for any links to B12 defiency with premature greying.

The link for pernicious anemia seems to be from damaged gut lining for Celiacs. I don't know if many doctors feel comfortable ordering the proper testing to diagnose it. Ordering the test for your B12 levels should be simple enough. A B12 causes nuerological problems if left untreated and it seems more of the general population are shown to be lacking.

IrishHeart Veteran

Good information on the selenium--thanks! I have Hashimoto's, which I've treated with Armour Thyroid for the past three years. I'll try eating the brazil nuts--as I recall, they're not too hard (have extremely brittle teeth).

I soak almonds for an hour before eating them...less rough on the teeth!! just a thought?!

Emma-Lee Rookie

vitamin and mineral deficiency is commonly overlooked by the medical community. If it weren't for your post I wouldn't have searched for any links to B12 defiency with premature greying.

The link for pernicious anemia seems to be from damaged gut lining for Celiacs. I don't know if many doctors feel comfortable ordering the proper testing to diagnose it. Ordering the test for your B12 levels should be simple enough. A B12 causes nuerological problems if left untreated and it seems more of the general population are shown to be lacking.

thank you! This info is really helpful and I appreciate the info to. I will ask for a B12

cO-ol Explorer

One thing that should be added is that you can have "normal" blood b12 levels and still be deficient (well, that's true of plenty of things, not just b12...). The first time I got mine checked I was 300; thankfully the doc saw that was too low despite the lab reference range low being 200. The second time I got my b12 checked I was 800 something, and the doc (a different one) condescendingly told me I didn't need to be taking the b12, but frankly, I feel much better taking it. See if you can get the MMA and homocysteine tests in addition to b12, because those tests usually can indicate a b12 issue even if the b12 blood test doesn't.

cassP Contributor

One thing that should be added is that you can have "normal" blood b12 levels and still be deficient (well, that's true of plenty of things, not just b12...). The first time I got mine checked I was 300; thankfully the doc saw that was too low despite the lab reference range low being 200. The second time I got my b12 checked I was 800 something, and the doc (a different one) condescendingly told me I didn't need to be taking the b12, but frankly, I feel much better taking it. See if you can get the MMA and homocysteine tests in addition to b12, because those tests usually can indicate a b12 issue even if the b12 blood test doesn't.

what's an MMA??

rosetapper23 Explorer

IrishHeart,

GREAT suggestion! I love almonds, but I stopped eating them some time ago because of the fragility of my teeth (broke three molars at one sitting last year). I'll definitely trying soaking some to see what happens.

Also, does anyone know a good source of Brazil nuts?? I can't seem to find any...

cassP Contributor

IrishHeart,

GREAT suggestion! I love almonds, but I stopped eating them some time ago because of the fragility of my teeth (broke three molars at one sitting last year). I'll definitely trying soaking some to see what happens.

Also, does anyone know a good source of Brazil nuts?? I can't seem to find any...

i bought mine in the refridgerated section at Chamberlains. ive also seen them at a local organic market/shop/cafe.

i havent looked at whole foods yet

good luck

  • 5 months later...
rogue Rookie

No one has replied to this thread for a while, so I'm not sure if anyone is still checking it. But I was searching for something else and came across this thread. Here are my two cents:

Yes, there could be a connection to premature graying of the hair and B12 deficiency. But the likely connection may lie in a hidden folic acid deficiency, which can cause graying of the hair. B12 issues can often mask a folic acid deficiency, so make sure that you get that tested right along with the B12. I actually have had a B12 deficiency for years, on and off, and only recently discovered the folic acid deficiency through my smart GI doc who knew to keep looking. Despite the fact that my dad and mom both grayed much later in life (in their late 40s/early 50s) I had found a few silvers on my own head (I'm in my early 30s), which was really shocking for me- I plucked them out! :lol: Now that I'm on folic acid supplements, hopefully my normal color will return. And hopefully yours too!

AVR1962 Collaborator

Once you have your blood work-up done make sure you ask for a copy of the results. I did not and doc did not share with me my deficencies. When I requested a copy from my records I was shocked, I had all these low marks. Rather than taking this to my doc I looked up each medical code online, you can find them by just googling. Started taking the various supplements for what I was low in and while it was a cure overnight I am feeling a ton better now.

I take B12 for my memory issues. I have had hair loss and had a bone scan that showed loss in both my spine and legs, my issues was pretty progressed before it was figured out what was causing the problem. I thought from my reading I saw that gray hair was due to low levels of minerals like copper that the body loses wiuth age.

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    • trents
      So, essentially all of the nutrition in the food we eat is absorbed through the villous lining of the small bowel. This is the section of the intestinal track that is damaged by celiac disease. This villous lining is composed of billions of finger-like projections that create a huge amount of surface area for absorbing nutrients. For the celiac person, when gluten is consumed, it triggers an autoimmune reaction in this area which, of course, generates inflammation. The antibodies connected with this inflammation is what the celiac blood tests are designed to detect but this inflammation, over time, wears down the finger-like projections of the villous lining. Of course, when this proceeds for an extended period of time, greatly reduces the absorption efficiency of the villous lining and often results in many and various nutrient deficiency-related health issues. Classic examples would be osteoporosis and iron deficiency. But there are many more. Low D3 levels is a well-known celiac-caused nutritional deficiency. So is low B12. All the B vitamins in fact. Magnesium, zinc, etc.  Celiac disease can also cause liver inflammation. You mention elevated ALP levels. Elevated liver enzymes over a period of 13 years was what led to my celiac diagnosis. Within three months of going gluten free my liver enzymes normalized. I had elevated AST and ALT. The development of sensitivities to other food proteins is very common in the celiac population. Most common cross reactive foods are dairy and oats but eggs, soy and corn are also relatively common offenders. Lactose intolerance is also common in the celiac population because of damage to the SB lining.  Eggs when they are scrambled or fried give me a gut ache. But when I poach them, they do not. The steam and heat of poaching causes a hydrolysis process that alters the protein in the egg. They don't bother me in baked goods either so I assume the same process is at work. I bought a plastic poacher on Amazon to make poaching very easy. All this to say that many of the issues you describe could be caused by celiac disease. 
    • catnapt
      thank you so much for your detailed and extremely helpful reply!! I can say with absolute certainty that the less gluten containing products I've eaten over the past several years, the better I've felt.   I wasn't avoiding gluten, I was avoiding refined grains (and most processed foods) as well as anything that made me feel bad when I ate it. It's the same reason I gave up dairy and eggs- they make me feel ill.  I do have a bit of a sugar addiction lol so a lot of times I wasn't sure if it was the refined grains that I was eating - or the sugar. So from time to time I might have a cookie or something but I've learned how to make wonderful cookies and golden brownies with BEANS!! and no refined sugar - I use date paste instead. Pizza made me so ill- but I thought it was probably the cheese. I gave up pizza and haven't missed it. the one time I tried a slice I felt so bad I knew I'd never touch it again. I stopped eating wheat pasta at least 3 yrs ago- just didn't feel well after eating it. I tried chick pea pasta and a few others and discovered I like the brown rice pasta. I still don't eat a lot of pasta but it's nice for a change when I want something easy. TBH over the years I've wondered sometimes if I might be gluten intolerant but really believed it was not possible for me to have celiac disease. NOW I need to know for sure- because I'm in the middle of a long process of trying to find out why I have a high parathyroid level (NOT the thyroid- but rather the 4 glands that control the calcium balance in your body) I have had a hard time getting my vit D level up, my serum calcium has run on the low side of normal for many years... and now I am losing calcium from my bones and excreting it in my urine (some sort of renal calcium leak) Also have a high ALP since 2014. And now rapidly worsening bone density.  I still do not have a firm diagnosis. Could be secondary HPT (but secondary to what? we need to know) It could be early primary HPT. I am spilling calcium in my urine but is that caused by the high parathyroid hormone or is it the reason my PTH is high>? there are multiple feedback loops for this condition.    so I will keep eating the bread and some wheat germ that does not seem to bother me too much (it hasn't got enough gluten to use just wheat germ)    but I'm curious- if you don't have a strong reaction to a product- like me and wheat germ- does that mean it's ok to eat or is it still causing harm even if you don't have any obvious symptoms? I guess what you are saying about silent celiac makes it likely that you can have no symptoms and still have the harm... but geez! you'd think they'd come up with a way to test for this that didn't require you to consume something that makes you sick! I worry about the complications I've been reading about- different kinds of cancers etc. also wondering- are there degrees of celiac disease?  is there any correlation between symptoms and the amnt of damage to your intestines? I also need a firm diagnosis because I have an identical twin sister ... so if I have celiac, she has it too- or at least the genetic make up for having it. I did have a VERY major stress to my body in 2014-2016 time frame .. lost 50lbs in a short period of time and had severe symptoms from acute protracted withdrawal off an SSRI drug (that I'd been given an unethically high dose of, by a dr who has since lost his license)  Going off the drug was a good thing and in many ways my health improved dramatically- just losing 50lbs was helpful but I also went  off almost a dozen different medications, totally changed my diet and have been doing pretty well except for the past 3-4 yrs when the symptoms related to the parathyroid issue cropped up. It is likely that I had low vit D for some time and that caused me a lot of symptoms. The endo now tells me that low vit D can be caused by celiac disease so I need to know for sure! thank you for all that great and useful information!!! 
    • trents
      Welcome, @catnapt! The most recent guidelines are the daily consumption of a minimum of 10g of gluten (about the amount found in 4-6 slices of wheat bread) for a minimum of two weeks. But if possible stretching that out even more would enhance the chances of getting valid test results. These guidelines are for those who have been eating gluten free for a significant amount of time. It's called the "gluten challenge".  Yes, you can develop celiac disease at any stage of life. There is a genetic component but also a stress trigger that is needed to activate the celiac genes. About 30-40% of the general population possesses the genetic potential to develop celiac disease but only about 1% of the general population actually develop celiac disease. For most with the potential, the triggering stress event doesn't happen. It can be many things but often it is a viral infection. Having said that, it is also the case that many, many people who eventually are diagnosed with celiac disease probably experienced the actual onset years before. Many celiacs are of the "silent" type, meaning that symptoms are largely missing or very minor and get overlooked until damage to the small bowel lining becomes advanced or they develop iron deficiency anemia or some other medical problem associated with celiac disease. Many, many are never diagnosed or are diagnosed later in life because they did not experience classic symptoms. And many physicians are only looking for classic symptoms. We now know that there are over 200 symptoms/medical problems associated with celiac disease but many docs are only looking for things like boating, gas, diarrhea. I certainly understand your concerns about not wanting to damage your body by taking on a gluten challenge. Your other option is to totally commit to gluten free eating and see if your symptoms improve. It can take two years or more for complete healing of the small bowel lining once going gluten free but usually people experience significant improvement well before then. If their is significant improvement in your symptoms when going seriously gluten free, then you likely have your answer. You would either have celiac disease or NCGS (Non Celiac Gluten Sensitivity).
    • catnapt
      after several years of issues with a para-gland issue, my endo has decided it's a good idea for me to be tested for celiac disease. I am 70 yrs old and stunned to learn that you can get celiac this late in life. I have just gradually stopped eating most foods that contain gluten over the past several years- they just make me feel ill- although I attributed it to other things like bread spiking blood sugar- or to the things I ate *with* the bread or crackers etc   I went to a party in Nov and ate a LOT of a vegan roast made with vital wheat gluten- as well as stuffing, rolls and pie crust... and OMG I was so sick! the pain, the bloating, the gas, the nausea... I didn't think it would ever end (but it did) and I was ready to go the ER but it finally subsided.   I mentioned this to my endo and now she wants me to be tested for celiac after 2 weeks of being on gluten foods. She has kind of flip flopped on how much gluten I should eat, telling me that if the symptoms are severe I can stop. I am eating 2-3 thin slices of bread per day (or english muffins) and wow- it does make me feel awful. But not as bad as when I ate that massive amnt of vital wheat gluten. so I will continue on if I have to... but what bothers me is - if it IS celiac, it seems stupid for lack of a better word, to intentionally cause more damage to my body... but I am also worried, on the other hand, that this is not a long enough challenge to make the blood work results valid.   can you give me any insight into this please?   thank you
    • trents
      The biopsy looks for damage to the mucosal lining of the small bowel from the inflammation caused by celiac disease when gluten is ingested. Once you remove gluten from the diet, inflammation subsides and the mucosal lining begins to heal. 
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