Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Question About Genetics

salexander421

Recommended Posts

salexander421 Enthusiast
salexander421
Posted

We first had my daughter gene tested since she was already on a gluten free diet at the time and found out she was positive for DQ8. I just recently got my gene test through enterolab and found out I have two copies of DQ8. This means that I got it from both of my parents and that both of my girls should have at least one copy of the gene. My question is, since my daughter only has one copy of the gene and obviously got it from me is it safe to say that my husband doesn't have the gene?

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


frieze Community Regular
frieze
Posted

simply put....no...he has two genes, the one he didnt give to DD may be celiac related

salexander421 Enthusiast
salexander421
Posted
  • Author

simply put....no...he has two genes, the one he didnt give to DD may be celiac related

I'm sorry, I guess I don't quite understand your answer. What do you mean he has two genes?

cassP Contributor
cassP
Posted

I'm sorry, I guess I don't quite understand your answer. What do you mean he has two genes?

my guess is that we dont have to have 2 genes related to celiac/gluten intolerance- from other people's results ive seen on here. so, he may have NO gluten related genes OR he might have (for example: a DQ8 & a DQ1)... then your daughter would have gotten her 1 DQ8 from u, and a DQ1 from the dad. did that make sense?

or lets say he only had 1 DQ gene, and it was a DQ7. then either your daughter would have her 1 DQ8 from u, and either a DQ7 or nothing from the dad.

at least that's my amateur understanding.

salexander421 Enthusiast
salexander421
Posted
  • Author

my guess is that we dont have to have 2 genes related to celiac/gluten intolerance- from other people's results ive seen on here. so, he may have NO gluten related genes OR he might have (for example: a DQ8 & a DQ1)... then your daughter would have gotten her 1 DQ8 from u, and a DQ1 from the dad. did that make sense?

or lets say he only had 1 DQ gene, and it was a DQ7. then either your daughter would have her 1 DQ8 from u, and either a DQ7 or nothing from the dad.

at least that's my amateur understanding.

That makes total sense that he could have one of the other gluten sensitive genes. But it would mean that he doesn't have DQ2 or DQ8 right? Since she got the DQ8 from me and she doesn't have DQ2, or is it possible to have one copy of a gene and not pass it on to your children? It's really just more of a curiousity thing :P I know there are other genes but right now I'm curious about DQ2 and DQ8.

Matisse Newbie
Matisse
Posted

"or is it possible to have one copy of a gene and not pass it on to your children?"

Yes, that's correct. He has two copies and the way genetics work is our children receive only one copy. In your case you have two DQ8 so your daughter had to receive a DQ8.

cassP Contributor
cassP
Posted

right just like matisse said... your husband could still have a DQ8.. but your daughter only has one- and she had to have gotten it from u, cause you have 2.

so your husband COULD have a DQ8 OR a DQ2.. but because of your daughter only having 1... then your husband's 2nd gene either has to be a different DQ gene like 1,3,7,9, etc...

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


eatmeat4good Enthusiast
eatmeat4good
Posted

You guys are a lot smarter than me!

It's fascinating though! :blink:;)

salexander421 Enthusiast
salexander421
Posted
  • Author

Ok, it's all making sense now :)

ElseB Contributor
ElseB
Posted

Something I recently found out:

- 100% of celiacs have one or both of the DQ2 & DQ8 genes, but so do 40% of the general population (i.e. 40% of the population has the genes but will never develop celiac).

- In celiac disease, the DQ2 & DQ8 genes constitute only 40% of the genetic load. 12 other genes comprise the remaining 60% of the genetic load.

mushroom Proficient
mushroom
Posted

Something I recently found out:

- 100% of celiacs have one or both of the DQ2 & DQ8 genes,

Only in the U.S., where it is considered by most that if you don't have either you cannot be. In other countries other genes are recognized as celiac genes.

cassP Contributor
cassP
Posted

Only in the U.S., where it is considered by most that if you don't have either you cannot be. In other countries other genes are recognized as celiac genes.

agreed.

i personally think all the DQ genes carry a potential risk- but maybe need more triggers- just my opinion.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      131,636
    • Most Online (within 30 mins)
      7,748
    Tiana
    Newest Member
    Tiana
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • trents
      Buckwheat

      By trents · Posted

      Keep in mind that with manufactured food products, "gluten free" doesn't equate to no gluten. Things that are naturally gluten free can be cross-contaminated with gluten in the field, in shipping and in processing. In the U.S. companies can use the gluten free label as long as the product doesn't exceed 20ppm of gluten. That amount still may cause a reaction in some people.
    • deanna1ynne
      Inconclusive results

      By deanna1ynne · Posted

      Dd10 was tested for celiac four years ago bc two siblings were dx’d (positive labs and biopsies). Her results at the time were positive ema  and ttg (7x the UL), but a negative biopsy. We checked again three months later and her ttg was still positive (4x the UL), but ema and biopsy were negative. Doc said it was “potential celiac” and to keep eating gluten, but we were concerned about harming her growth and development while young and had her go gluten-free because we felt the labs and ema in particular were very suggestive of early celiac, despite the negative biopsies. She also had stomach aches and lethargy when eating it. We just felt it’d be better to be safe than sorry. Now, four years later, she doesn’t want to be gluten-free if she doesn’t “have to be,” so underwent a 12 week gluten challenge. She had labs done before starting and all looked great (celiac panel all negative, as expected.) Surprisingly, she experienced no noticeable symptoms when she began eating gluten again, which we felt was a positive sign. However, 12 weeks in, her labs are positive again (ttg 4x the UL and ema positive again as well). Doc says that since she feels fine and her previous two biopsies showed nothing, she can just keep eating gluten and we could maybe biopsy again in two years. I was looking up the ema test and the probability of having not just one but two false positives, and it seems ridiculously low.  Any advice? Would you biopsy again? She’s old enough at this point that I really feel I need her buy-in to keep her gluten-free, and she feels that if the doc says it’s fine, then that’s the final word — which makes me inclined to biopsy again and hope that it actually shows damage this time (not because I want her to have celiac like her sisters, but because I kind of think she already does have it, and seeing the damage now would save her more severe damage in the long run that would come from just continuing to eat gluten for a few more years before testing again.)  Our doc is great - we really like him. But we are very confused and want to protect her. One of her older sibs stopped growing and has lots of teeth problems and all that jazz from not catching the celiac disease sooner, and we don’t want to get to that point with the younger sis. fwiw- she doesn’t mind the biopsy at all. It’s at a children’s hospital and she thinks it’s kind of fun. So it’s not like that would stress her out or anything.
    • Inkie
      Buckwheat

      By Inkie · Posted

      Thanks for the replies. I already use a gluten-free brand of buckwheat flakes I occasionally get itchy bumps. I'm still reviewing all my food products. I occasionally eat prepackaged gluten-free crackers and cookies, so I'll stop using those. I use buckwheat flakes and Doves Farm flour as a base for baking. Would you recommend eliminating those as well? It's a constant search.
    • Wheatwacked
      Frequent nausea after gluten-free diet

      By Wheatwacked · Posted

      Gluten free food is not fortified with vitamins and minerals as regular food is.  Vitamin deficiencies are common especially in recently diagnosed persons,  Get a 25(OH)Vitamin D blood test. And work on raising it.  The safe upper blood level is around 200 nmol/L.    "Low serum levels of 25(OH)D have been associated with increased risk of autoimmune disease onset and/or high disease activity. The role of vitamin D in autoimmune diseases   🏋️‍♂️Good job!   I find the commercial milk will give me mild stomach burn at night, while pasture/grassfed only milk does not bother me at all.  While you are healing, listen to your body.  If it hurts to eat something, eat something else.  You may be able to eat it later, or maybe it is just not good for you.  Lower your Omega 6 to 3 ratio of what you eat.  Most omega 6 fatty acids are inflammation causing.    The standard american diet omega 6:3 ratio is estimated at upward of 14:1.  Thats why fish oil works
    • Inkie
      Thee

      By Inkie · Posted

      I  notice a reaction to tea bags, possibly due to gluten or other substances. Is this recognizable?
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.