Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Mayo Clinic Easy To Read Celiac Testing Algorithm

pgrovetom

Recommended Posts

pgrovetom Rookie
pgrovetom
Posted

I found this very helpful. Its the Mayo Clinic's Celiac diagnosis flow chart. Check it out. Its about the most straightforward way to describe the standard method for diagnosing Celiac.

Open Original Shared Link

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


tarnalberry Community Regular
tarnalberry
Posted

I must say that I hate that the chart says that if you don't have one of the most common two genes, you can't have celiac. But this is otherwise a decent chart. I do love that it says about 10% test seronegative.

organicmama Contributor
organicmama
Posted

Do you have that article about the other genes? I remember reading it but haven't found again.

beachbirdie Contributor
beachbirdie
Posted

I found this very helpful. Its the Mayo Clinic's Celiac diagnosis flow chart. Check it out. Its about the most straightforward way to describe the standard method for diagnosing Celiac.

Open Original Shared Link

That is interesting to look at. Makes it easy to think one's way through the puzzles. By the Mayo Clinic chart, I should be asking for more testing since I had more than 4 units of TTG IgA.

Wonder if my doc will do the Deamidated Gliadin antibody...

pgrovetom Rookie
pgrovetom
Posted
  • Author

That is interesting to look at. Makes it easy to think one's way through the puzzles. By the Mayo Clinic chart, I should be asking for more testing since I had more than 4 units of TTG IgA.

Wonder if my doc will do the Deamidated Gliadin antibody...

My Kaiser Docs ONLY tested TTG IgA and yet I took the Labcorp Comprehensive panel myself almost 2 years ago and only failed the DGA IgA badly at 10.4 with a 0-10 range. I passed all the other tests in the panel. According to the Mayo Clinic, given their reputation, the Kaiser Docs cut corners by doing only the one test plus they violated the current recommendations of 4 samples in the biopsy plus they ignored the DQ2 and DQ8 tests.

Don't ever trust Kaiser as they cut corners such that the diagnostic success is seriously compromised. Now I plan On bringing this and other articles to them plus I went ahead and did the DQ2 and DQ8 tests myself this week and have yet to get results. Since I've been on a Gluten free diet almost 2 years ( but suspect contamination or something else), I might not test correctly but when you are desperate, you do what you can.

Even though the Mayo diagram is good, it doesn't really recognize that Gluten sensitivity reactions by themselves without any or much intestine damage is a real problem.

ravenwoodglass Mentor
ravenwoodglass
Posted

I found this very helpful. Its the Mayo Clinic's Celiac diagnosis flow chart. Check it out. Its about the most straightforward way to describe the standard method for diagnosing Celiac.

Open Original Shared Link

Gee going by their chart I guess I don't really have celiac. It must all be 'in my head'. :unsure::angry: Guess I should pull out my tackle box of drugs that I had to take prediagnosis and go have a big mac. Y'all will come to my funeral right......

sue1234 Rookie
sue1234
Posted

I do know one thing--celiac or gluten intolerance is NOT an easy, logorithmic thing that can diagnosed by a flow chart!

I am still sitting as undiagnosed. Let me show where my numbers fit into this:

My tTG is 0. So, if you stop there, I am completely negative.

BUT, my doctor also tested my deaminated antigliadin IgA, and it was 45.4(0-10).

According to their chart, a negative tTG just means no celiac, stop testing. BUT, if it is positive, THEN test the antigliadin. Why? I thought the tTG was "the" blood test to rule in/out celiac. So why do further testing???

Then, if the antigliadin is over 10, biopsy. Mine was 4x the upper limit, yet the biopsy was negative. So, where do I fit into all this? I think they are missing something here, possibly that my 4x antigliadin maybe represents gluten intolerance?

This is soooo confusing.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


tarnalberry Community Regular
tarnalberry
Posted

But how can you provide reproduce-able studies if you don't have flow charts and algorithms? :rolleyes:

I think a lot of the newer generation doctors forget that there is as much art to being a physician as there is science.

beachbirdie Contributor
beachbirdie
Posted

Gee going by their chart I guess I don't really have celiac. It must all be 'in my head'. :unsure::angry: Guess I should pull out my tackle box of drugs that I had to take prediagnosis and go have a big mac. Y'all will come to my funeral right......

:lol: You have a wonderful sense of humor! You got me ROFL!

It was hard enough to get a doc to think "outside the box" for thyroid care, celiac is ten times trickier!

Please, do stay away from that Big Mac! :o

eatmeat4good Enthusiast
eatmeat4good
Posted

I think a lot of the newer generation doctors forget that there is as much art to being a physician as there is science.

And a lot of them should really have been "Artists" instead of Doctors...at least in my experience... :huh::unsure:

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,133
    • Most Online (within 30 mins)
      7,748
    Exhausted-momma
    Newest Member
    Exhausted-momma
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • knitty kitty
      High DGP-A with normal IGA

      By knitty kitty · Posted

      @rei.b,  I understand how frustrating starting a new way of eating can be.  I tried all sorts of gluten-free processed foods and just kept feeling worse.  My health didn't improve until I started the low histamine AIP diet.  It makes a big difference.   Gluten fits into opioid receptors in our bodies.  So, removing gluten can cause withdrawal symptoms and reveals the underlying discomfort.  SIBO can cause digestive symptoms.  SIBO can prevent vitamins from being absorbed by the intestines.  Thiamine insufficiency causes Gastrointestinal Beriberi (bloating, abdominal pain, nausea, diarrhea or constipation).  Thiamine is the B vitamin that runs out first because it can only be stored for two weeks.  We need more thiamine when we're sick or under emotional stress.  Gastric Beriberi is under recognised by doctors.  An Erythrocyte Transketolace Activity test is more accurate than a blood test for thiamine deficiency, but the best way to see if you're low in thiamine is to take it and look for health improvement.  Don't take Thiamine Mononitrate because the body can't utilize it well.  Try Benfotiamine.  Thiamine is water soluble, nontoxic and safe even at high doses.  I thought it was crazy, too, but simple vitamins and minerals are important.  The eight B vitamins work together, so a B Complex, Benfotiamine,  magnesium and Vitamin D really helped get my body to start healing, along with the AIP diet.  Once you heal, you add foods back in, so the AIP diet is worth doing for a few months. I do hope you'll consider the AIP diet and Benfotiamine.
    • captaincrab55
      Finding gluten free ingredients

      By captaincrab55 · Posted

      Imemsm, Most of us have experienced discontinued, not currently available or products that suddenly become seasonal.   My biggest fear about relocating from Maryland to Florida 5 years ago, was being able to find gluten-free foods that fit my restricted diet.  I soon found out that the Win Dixie and Publix supper markets actually has 99% of their gluten-free foods tagged, next to the price.  The gluten-free tags opened up a  lot of foods that aren't actually marked gluten-free by the manufacture.  Now I only need to check for my other dietary restrictions.  Where my son lives in New Hartford, New York there's a Hannaford Supermarket that also has a gluten-free tag next to the price tag.  Hopefully you can locate a Supermarket within a reasonable travel distance that you can learn what foods to check out at a Supermarket close to you.  I have dermatitis herpetiformis too and I'm very sensitive to gluten and the three stores I named were very gluten-free friendly.  Good Luck 
    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

      Okay well the info about TTG-A actually makes a lot of sense and I wish the PA had explained that to me. But yes, I would assume I would have intestinal damage from eating a lot of gluten for 32 years while having all these symptoms. As far as avoiding gluten foods - I was definitely not doing that. Bread, pasta, quesadillas (with flour tortillas) and crackers are my 4 favorite foods and I ate at least one of those things multiple times a day e.g. breakfast with eggs and toast, a cheese quesadilla for lunch, and pasta for dinner, and crackers and cheese as a before bed snack. I'm not even kidding.  I'm not really big on sugar, so I don't really do sweets. I don't have any of those conditions.  I am not sure if I have the genes or not. When the geneticist did my genetic testing for EDS this year, I didn't think to ask for him to request the celiac genes so they didn't test for them, unfortunately.  I guess another expectation I had is  that if gluten was the issue, the gluten-free diet would make me feel better, and I'm 3 months in and that hasn't been the case. I am being very careful and reading every label because I didn't want to screw this up and have to do gluten-free for longer than necessary if I end up not having celiac. I'm literally checking everything, even tea and anything else prepacked like caramel dip. Honestly its making me anxious 😅
    • knitty kitty
      High DGP-A with normal IGA

      By knitty kitty · Posted

      So you're saying that you think you should have severe intestinal damage since you've had the symptoms so long?   DGP IgG antibodies are produced in response to a partial gluten molecule.  This is different than what tissue transglutaminase antibodies are  produced in response to.   TTg IgA antibodies are produced in the intestines in response to gluten.  The tTg IgA antibodies attack our own cells because a structural component in our cell membranes resembles a part of gluten.  There's a correlation between the level of intestinal damage with the level of tTg antibodies produced.  You are not producing a high number of tTg IgA antibodies, so your level of tissue damage in your intestines is not very bad.  Be thankful.   There may be reasons why you are not producing a high quantity of tTg IgA antibodies.  Consuming ten grams or more of gluten a day for two weeks to two months before blood tests are done is required to get sufficient antibody production and damage to the intestines.  Some undiagnosed people tend to subconsciously avoid lots of gluten.  Cookies and cakes do not contain as much gluten as artisan breads and thick chewy pizza crust.  Anemia, diabetes and thiamine deficiency can affect IgA antibody production as well.   Do you carry genes for Celiac?  They frequently go along with EDS.
    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

      I was tested for celiac at the same time, so I wasn't taking naltrexone yet. I say that, because I don't. The endoscopy showed some mild inflammation but was inconclusive as to celiac disease. They took several biopsies and that's all that was shown. I was not given a Marsh score.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.