Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

? I Got Answered Wasn't What I Expected....

carecare

Recommended Posts

carecare Enthusiast
carecare
Posted

I sent a question to the University of Chicago Celiac Disease Center on facebook regarding the DGP being elevated and what they thought that would mean if a child came back with a negative biopsy. I wanted to know if other tests were negative but the Deaminated gliadin IgG was flagged as HIGH and positive if that would possibly mean more of a gluten intolerance rather than celiac. I did not receive the answer I was asking for...but their response was a little surprising:

"DGP of the IgG type may be "falsely" positive, meaning they can be slightly elevated in people who do not have celiac. So, the biopsy (done after being on a gluten-containing diet for at least 12 weeks) becomes of paramount importance."

That was a first that I've read that the IgG could be falsely positive. Also, my son was not just slightly elevated...as the results, which told me it did not go to an endpoint or something like that, but was flagged as in the high range.

So I responded back asking what slightly elevated means in their eyes...and if they'd anwser my original question of "if the biopsy is negative could that possibly mean a gluten intolerance."

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


mushroom Proficient
mushroom
Posted

Do they have lilttle elves sitting their choosing answers out of a standard book? That's what it sounds like.....

The Horticulturalist Apprentice
The Horticulturalist
Posted

I sent a question to the University of Chicago Celiac Disease Center on facebook regarding the DGP being elevated and what they thought that would mean if a child came back with a negative biopsy. I wanted to know if other tests were negative but the Deaminated gliadin IgG was flagged as HIGH and positive if that would possibly mean more of a gluten intolerance rather than celiac. I did not receive the answer I was asking for...but their response was a little surprising:

"DGP of the IgG type may be "falsely" positive, meaning they can be slightly elevated in people who do not have celiac. So, the biopsy (done after being on a gluten-containing diet for at least 12 weeks) becomes of paramount importance."

That was a first that I've read that the IgG could be falsely positive. Also, my son was not just slightly elevated...as the results, which told me it did not go to an endpoint or something like that, but was flagged as in the high range.

So I responded back asking what slightly elevated means in their eyes...and if they'd anwser my original question of "if the biopsy is negative could that possibly mean a gluten intolerance."

Don't have an answer really, just wondering it you had the Ttg and the EMA done as well for your son?

I take it from your post that your son did have a -ve biopsy and the postive bloods, or is this a hypothetical question?

I guess it's possible that the biopsy potentially missed any area of damage caused by celiac, do you know where the biopsies were taken and how many?

gfcolorado Newbie
gfcolorado
Posted

I have tried to do a lot of research also on the DGP test. I was diagnosed with Celiac 3 years ago. I just went for a follow-up and my TTG, DGP IGG and EMA were negative but my DGP IGA was positive. I asked numerous people (my GI, Rodney Ford, manufacturers of the test, an allergist) and everyone's answers were different. Several (my GI and test manufacturer) felt that it wasn't from a one time recent accidental gluten exposure but rather continued daily exposure.

I decided to have an endoscopy just so I know what is really happening and because I've never had a follow-up. I will get the results hopefully this week and will post and let you know. Please let me know if you find additional info. Thanks!

carecare Enthusiast
carecare
Posted
  • Author

My question was hypothetical because I was just curious. My son (just turned 12) and is getting an endoscopy in mid December. He did get a full celiac panel done...everything was negative except for the high DPG IgG. I'm happy to report that the doctor told me he would do 9+ biopsies of the small intestines because he is indeed looking for celiac...better than the 2 that the nurse originally told me. It's currently a loooong wait for that biopsy....he was gluten-free for almost 2 months and muscle pain free and canker sore free during that time...then the day after we started back on gluten so the biopsy would be accurate his symptoms came roaring back sooo much worse than before. He can't wait to become gluten-free for life once the biopsy is over with!

GFColorado...yes....report back and let us know how the biopsy turns out.

Oh...and funny...they couldn't answer my question right away because they said they would send it to their experts who answer these kinds of questions for them.

Skylark Collaborator
Skylark
Posted

In the few studies who have followed folks with positive TTG, GI symptoms, but negative biopsy, the people tend to become celiac by biopsy in a few years. DGP-IgG is considered as good if not better than TTG IgA. I'm glad he will be going gluten-free.

Open Original Shared Link

Di2011 Enthusiast
Di2011
Posted

I have tried to do a lot of research also on the DGP test. I was diagnosed with Celiac 3 years ago. I just went for a follow-up and my TTG, DGP IGG and EMA were negative but my DGP IGA was positive. I asked numerous people (my GI, Rodney Ford, manufacturers of the test, an allergist) and everyone's answers were different. Several (my GI and test manufacturer) felt that it wasn't from a one time recent accidental gluten exposure but rather continued daily exposure.

I decided to have an endoscopy just so I know what is really happening and because I've never had a follow-up. I will get the results hopefully this week and will post and let you know. Please let me know if you find additional info. Thanks!

Please let us know the result of the endoscopy.. lots of us will be interested

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


gfcolorado Newbie
gfcolorado
Posted

Please let us know the result of the endoscopy.. lots of us will be interested

I will post as soon as I find out. My doctor did 12 biopsies so it should give a good picture of what's going on. This forum has been so helpful and glad I can provide info to help others. I think it's such a new test that there aren't all the answers we want.

  • 3 weeks later...
carecare Enthusiast
carecare
Posted
  • Author

So either the University of Chicago Celiac people are flakes or they just misinterpreted my question. I asked about my son's deamidated IGg being strong positive and if they would think that would indicate more of an sensitivity/intolerance and not celiac if his biopsy was negative (which hasn't been done yet). I know I've read research saying it's very specific and highly indicative of celiac disease but curiosity got the better of me and I posted the question. The last response to me stated: "Elevated IgG (for tTG, I presume) are notoriously unspecific and should be simply disregarded."

Skylark Collaborator
Skylark
Posted

Wow. They don't read very carefully, do they?

  • 10 months later...
gfcolorado Newbie
gfcolorado
Posted

I will post as soon as I find out. My doctor did 12 biopsies so it should give a good picture of what's going on. This forum has been so helpful and glad I can provide info to help others. I think it's such a new test that there aren't all the answers we want.

I just realized I never wrote in with answers on my biopsy after testing positive for DGP IGA. It was negative. But, it's now a year later and I just did yearly bloodwork and my TTG IGA is still negative but DGP IGA is 31 (moderate to strong positive is 30+). I have no idea why this is. I have contacted several Celiac specialists in hopes of an answer.

vtphd Newbie
vtphd
Posted

I just realized I never wrote in with answers on my biopsy after testing positive for DGP IGA. It was negative. But, it's now a year later and I just did yearly bloodwork and my TTG IGA is still negative but DGP IGA is 31 (moderate to strong positive is 30+). I have no idea why this is. I have contacted several Celiac specialists in hopes of an answer.

GfColorado, I also only have a positive IGA but mine is 20.9 (only .9) into the "equivocal" range.

What have the other people you've consulted said? Both my GI and my PCP say it does not mean I have Celiac...but maybe intolerance. They also claim false positives happen....

Immunoglobulin A -- 229 (range 68-378)

Endomysial IgA- negative

tTG-IgG Ab -- 3.9 (range under 20 negative)

tTG-IgA Ab -- 8.9 (range under 20 negative)

Gliadin Peptide Ab IgG --7.0 (range under 20 negative)

Gliadin Peptide Ab IgA -- 20.9 (range under 20 negative, 20-25 equivocal, 25+ positive)

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. trents
      - trents replied to Francis M's topic in Gluten-Free Restaurants
      1

      The Happy Tart review

      Was the card itself lost or just the record or both?
    2. Francis M
      - Francis M posted a topic in Gluten-Free Restaurants
      1

      The Happy Tart review

      We were flabergasted that the owner would not acknowledge a $50 e-gift card I purchased for my celiac wife. My wife tried to open it in the store and was informed there had been a system change and they could not find the record. No worries, she was told, just talk to management. Six months later, and numerous absurd back and forths, and the owner literally...
    3. trents
      - trents replied to Colleen H's topic in Gluten-Free Foods, Products, Shopping & Medications
      10

      Ibuprofen

      Yes, some people do get withdrawal from gluten but gluten withdrawal doesn't usually cause gut pain. Maybe more like general body aches and discomfort. We have articles on gluten withdrawal on this forum. You might do a search for them. Applesauce is very acidic and some brands have added vitamin C (ascorbic acid) which makes them more acidic. This can...
    4. Colleen H
      - Colleen H replied to Colleen H's topic in Gluten-Free Foods, Products, Shopping & Medications
      10

      Ibuprofen

      Do you or anyone know alot about ibuprofen I wasn't sure if I was eating too much apple sauce. Something is making my pain so much worse I'm referring to the intense pins and needles in my feet and lower legs. Jaw actually has tardive dystonia and muscle spasms throughout my back Almost like an opposite effect that a pain reliever...
    5. Colleen H
      - Colleen H replied to Colleen H's topic in Gluten-Free Foods, Products, Shopping & Medications
      10

      Ibuprofen

  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      131,848
    • Most Online (within 30 mins)
      7,748
    Francis M
    Newest Member
    Francis M
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.4k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Who's Online (See full list)

  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • trents
      The Happy Tart review

      By trents · Posted

      Was the card itself lost or just the record or both?
    • Francis M
      The Happy Tart review

      By Francis M · Posted

      We were flabergasted that the owner would not acknowledge a $50 e-gift card I purchased for my celiac wife. My wife tried to open it in the store and was informed there had been a system change and they could not find the record. No worries, she was told, just talk to management. Six months later, and numerous absurd back and forths, and the owner literally informs me there have been "bad actors", so she can't make good on this lost gift card. In other words, she accused me of lying and committing fraud... over $50! Please be careful with your orders and purchases here.
    • trents
      Ibuprofen

      By trents · Posted

      Yes, some people do get withdrawal from gluten but gluten withdrawal doesn't usually cause gut pain. Maybe more like general body aches and discomfort. We have articles on gluten withdrawal on this forum. You might do a search for them. Applesauce is very acidic and some brands have added vitamin C (ascorbic acid) which makes them more acidic. This can damage the stomach lining if you eat it too often. Especially if your stomach lining is already compromised. Ibuprofen inhibits the body's ability to rebuild the stomach's protective mucosal lining. That's why it can cause peptic ulcers. As strange as it may sound, low level irritation/inflammation stimulates the body to rebuild the stomach lining. There are two steps in this rebuilding process known as COX 1 and COX 2. Ibuprofen represses both COX 1 and COX 2. Celecoxcib, a prescription anti inflammatory, inhibits only COX 2, making it less likely to cause damage to the gut lining.
    • Colleen H
      Ibuprofen

      By Colleen H · Posted

      Do you or anyone know alot about ibuprofen  I wasn't sure if I was eating too much apple sauce.   Something is making my pain so much worse  I'm referring to the intense pins and needles in my feet and lower legs.  Jaw actually has tardive dystonia and muscle spasms throughout my back Almost like an opposite effect that a pain reliever would do. I'm fairly new to this. Whatever is going on seems to be worsening  Do people get a withdrawal effect from gluten?  It's extremely painful 😖  I'll post that question or research on the site  Thank you everyone for responding 
    • Colleen H
      Ibuprofen

      By Colleen H · Posted

×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.