Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Explain Positive Biopsy In English :)

Mom-of-Two

Recommended Posts

Mom-of-Two Contributor
Mom-of-Two
Posted

I already knew I was celiac based on hugely positive blood panel, I had the biopsy done and the nurse gave me results over the phone basically saying that yes, my gut says I have celiac. (not a surprise)

I finally got the actual copy of the report in the mail, and thought someone could interpret. Just curious!

Diagnosis:

Duodenum, biopsy -- variable villous abnormality with marked intraepithelial lymphocytosis.

The pattern of injury is highly suggestive of a gluten sensitive enteropathy, correlation with serologic data is required to confim diagnosis.

I have not heard of that before, the intraepithelial lymphocytosis, is this just damage, or something particular, less damage, more damage?

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Skylark Collaborator
Skylark
Posted

The "intraepithelial lymphocytosis" means that there are a lot of white blood cells (lymphocytes) in your biopsy. There are not normally a lot of lymphocytes in the mucosa, just a few here and there to deal with food-borne bacteria. The autoimmune antibodies in celiac disease signal large numbers of a particular type of lymphocyte called natural killer cells to come to your intestines. These cells usually kill invading bacteria and viruses; in celiac disease they get confused and instead kill your villi.

The intraepithelial lymphocytosis happens in everyone with celiac disease. It precedes the damage and doctors are starting to consider it an early indicator of celiac. The villous abnormality they mention in your biopsy is the start of the autoimmune damage. It sounds like you're not in too bad shape. The diet should sort things right out. B)

Mom-of-Two Contributor
Mom-of-Two
Posted
  • Author

Great, thanks!! :)

That would explain why I do not have vitamin and nutrient deficiencies perhaps. I have had the stomach bloating and cramps for 2-3 years. I had what I thought was lactose/milk issues as a teen and young adult, when I found out I had celiac I thought perhaps those were my symptoms all along, but I'm 32 so I would have pretty severe damage by now if I had active celiac all my lfe! My GI dr, and myself, believe this was likely brought on by the abdominal surgery and sepsis I had 5 years ago, with 2 months of strong antibiotics that damged my gut as well.

That info was helful.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      130,851
    • Most Online (within 30 mins)
      7,748
    Suzanne Clarke
    Newest Member
    Suzanne Clarke
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.3k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Awol cast iron stomach
      Work friends & food

      By Awol cast iron stomach · Posted

      I just wanted to share my support for you. Rant away. We all know that, and have experiences like that at some point. I am sorry for that very unpleasant, and emotionally isolating reminder of your medical condition. Which always is exacerbated by the hunger. I will admit many of my family friends, and coworkers found it easier to exclude me than to accommodate me. I also have to be very strict with cross contamination so in hindsight they did me a favor.  The sting however can often still be unearthed when I read experiences like yours.  I am sorry you had that occur. I hope you, and the coworkers can find the easy more accommodating experiences again after this unfortunate incident. Best wishes. 
    • Awol cast iron stomach
      Diagnosed gluten allergy but not Celiac

      By Awol cast iron stomach · Posted

      "...hemorrhoids, constipation and diarrhea" . Heard of indeed. Experienced too. In hindsight, I can remember from age 2 having, and trying to convey my issues. I went 38 years misdiagnosed. So yes one can have these issues. I did have to go back on gluten for a gluten challenge. I failed that challenge and 6 days in they give me permission to stop, and I proceed with my scopes as scheduled. Post those 6 days I had gained 13 intolerances. I had to remove many foods, and reintroduce them back in. Nine years later I have two that remain gluten, and corn. I found it helpful to follow a whole foods diet. I also found autoimmune (AIP) protocol diet/recipes, and Paleo diet/recipes helpful. I still enjoy many of those homemade version recipes. I still continue to make my own salad dressings even if I can find a gluten-free store bought version. Fresh taste best to this palate now.  I did give up many grains I was off many and reverted to coconut flour and almond flour as work arounds .  I still remember the first time my gut experienced the reintroduction of quinoa. It wasn't sure if it wanted to flare or not. In 30 minutes it reported back ok this will pass. Many foods were removed post gluten challenge for me for 2 years and 4 months. At the 2 year 4 month mark is when my body said ok let's eat again, but don't ever feed me gluten again! I wish you the best.   
    • Scott Adams
      Gluten-Free Newbie

      By Scott Adams · Posted

      if you have already learned that Gluten is the cause of your symptoms, of course there is no need to add it back into your diet— your decision could save you a lot of needless suffering. One thing to consider is that if you do have celiac disease, your first- degree relatives may also need to get screened for it, because, like diabetes the disease is genetic, although many of its triggers seem to be environmental factors. You may want to consider getting a genetic test for celiac disease, so you can at least warn your relatives if it turns out that you do carry a celiac gene.
    • lookingforanswersone
      TTG IgA 0.30 U/ml: further tests?

      By lookingforanswersone · Posted

      Thanks everyone. I've decided to do a gluten challenge (4 slices of bread a day for 3 months) and then do a full gluten panel of all the tests that can be done, just to rule it in or out for sure. I think otherwise psychologically it will keep bothering me 
    • Suze046
      Gluten-Free Newbie

      By Suze046 · Posted

      Thanks Scott. Those articles are really interesting. I’m cutting out gluten for 6 weeks but honestly I’m not sure I even want to reintroduce it! I ate at a restaurant for the first time on Wednesday and then Thursday was really uncomfortable and had a few trips to the loo.. wonder if there was some cross contamination 🤷‍♀️ if that’s how my body reacts after not eating it for 3 weeks I’m not sure it’s worth reintroducing it and re testing for celiac! It might have been a coincidence I realise that I’m not going to feel better all of a sudden and my gut is probably still trying to heal. Thanks for your supportive message! 
×
×
  • Create New...