Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Dgp Igg Quick Question

MoMof2Boyz

Recommended Posts

MoMof2Boyz Enthusiast
MoMof2Boyz
Posted

does a negative DGP IgG indicate no celiac? all IgA tests are negative but a low total serum IgA which I know means a false negative on the IgA tests but what about the DGP IgG?

thanks!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


beachbirdie Contributor
beachbirdie
Posted

does a negative DGP IgG indicate no celiac? all IgA tests are negative but a low total serum IgA which I know means a false negative on the IgA tests but what about the DGP IgG?

thanks!

Sorry to answer a question with a question, did they do any other IgG tests?

A doctor might interpret a negative DGP IgG as no celiac, but as you've probably gleaned from reading around here, false negatives can be common.

Off to read some of your other posts...I don't recall the background info. :unsure:

Ahhh...okay, just saw the test results. As mushroom mentioned in one of your threads, you should ask the doc to run the EMA-IgG and the TtG IgG. There was not enough testing to really rule it out, given the IgA deficiency. All the tests but one were IgA tests and are meaningless.

There are some around here who only had one positive test, the TtG IgG, yet they did have celiac and is showed on their biopsy. I was one whose only positive test was TtG IgG. I'm not biopsy diagnosed, but my doc decided to call it celiac given my symptoms and relief off gluten.

Try to get those other two tests done.

Skylark Collaborator
Skylark
Posted

does a negative DGP IgG indicate no celiac? all IgA tests are negative but a low total serum IgA which I know means a false negative on the IgA tests but what about the DGP IgG?

thanks!

False negatives are possible on all celiac blood tests, particularly in kids. DGP has 90% sensitivity at best so 1 in 10 celiacs will be missed. Celiac is less likely with negative DGP IgG, and low total IgA will not affect the results.

nora-n Rookie
nora-n
Posted

there is no EMA-IgG.

The endomysium test isa manual test where they look for IgA deposits under an electron microscope

Skylark Collaborator
Skylark
Posted

there is no EMA-IgG.

The endomysium test isa manual test where they look for IgA deposits under an electron microscope

I think you have anti-EMA confused with the dermatitis herpetiformis biopsy, Nora. Anti-EMA is an immunofluorescence assay done with standard fluorescence microscopy. The patient's serum is reacted with monkey esophagus at varying titers and then stained with a fluorescent secondary antibody. It can test for either IgG or IgA depending on which secondary antibody is used.

nora-n Rookie
nora-n
Posted

ok, but I have not seen anyone reporting of having had thenEMA IgG done, and someone posted here some years ago there is no EMA IgG, just IgA so I thought so it was

frieze Community Regular
frieze
Posted

Open Original Shared Link

only used in IgA def persons. wonder if it is fairly new?

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Skylark Collaborator
Skylark
Posted

Open Original Shared Link

only used in IgA def persons. wonder if it is fairly new?

No. It's not new at all. It just uses an IgG rather than IgA specific secondary antibody. That technology has been around for over 20 years.

nora-n Rookie
nora-n
Posted

sometimes they call the tissue transglutamiase test for EMA (maybe because several years ago the EMA was more known than the then new Ttg test) I have seen that sometimes

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,017
    • Most Online (within 30 mins)
      7,748
    Sjcucinotta
    Newest Member
    Sjcucinotta
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • sleuth
      Nicotine Gum For Gluten Symptoms.. Am I Crazy?

      By sleuth · Posted

      He is not just a psychiatrist.  He is also a neuroscientist.  And yes, I have already read those studies.   I agree with benfotiamine.  This is short term while glutened/inflammation occurs.  As I had already mentioned, these symptoms no longer exist when this phase passes.  And yes, I know that celiac is a disease of malnutrition.  We are working with a naturopath.
    • knitty kitty
      Nicotine Gum For Gluten Symptoms.. Am I Crazy?

      By knitty kitty · Posted

      Please do more research before you settle on nicotine. Dr. Paul New house is a psychiatrist.  His latest study involves the effect of nicotine patches on Late Life Depression which has reached no long term conclusions about the benefits.   Effects of open-label transdermal nicotine antidepressant augmentation on affective symptoms and executive function in late-life depression https://pubmed.ncbi.nlm.nih.gov/39009312/   I'm approaching the subject from the Microbiologist's point of view which shows nicotine blocks Thiamine B1 uptake and usage:   Chronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells https://pubmed.ncbi.nlm.nih.gov/26633299/   While supplementation with thiamine in the form Benfotiamine can protect from damage done by  nicotine: Benfotiamine attenuates nicotine and uric acid-induced vascular endothelial dysfunction in the rat https://pubmed.ncbi.nlm.nih.gov/18951979/   I suggest you study the beneficial effects of Thiamine (Benfotiamine and TTFD) on the body and mental health done by Dr. Derrick Lonsdale and Dr. Chandler Marrs.  Dr. Lonsdale had studied thiamine over fifty years.   Hiding in Plain Sight: Modern Thiamine Deficiency https://pmc.ncbi.nlm.nih.gov/articles/PMC8533683/ I suggest you read their book Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition.     Celiac Disease is a disease of malabsorption causing malnutrition.  Thiamine and benfotiamine: Focus on their therapeutic potential https://pmc.ncbi.nlm.nih.gov/articles/PMC10682628/
    • sleuth
      Nicotine Gum For Gluten Symptoms.. Am I Crazy?

      By sleuth · Posted

      Thanks for your response.  Everything you mentioned he is and has been doing.  Tobacco is not the same as nicotine.  Nicotine, in the form of a patch, does not cause gastrointestinal irritation.  Smoking does. He is not smoking.  Please do your research before stating false information. Dr. Paul Newhouse has been doing research on nicotine the last 40 years at Vanderbilt University Medical Center.  
    • Jmartes71
      Fighting for a name

      By Jmartes71 · Posted

      Im so frustrated and still getting the run around trying to reprove my celiac disease which my past primary ignored for 25 years.I understand that theres a ray of medical that doctors are limited too but not listening and telling the patient ( me) that im not as sensitive as I think and NOT celiac!Correction Mr white coat its not what I think but for cause and affect and past test that are not sticking in my medical records.I get sick violently with foods consumed, not eating the foods will show Im fabulous. After many blood draws and going through doctors I have the HLA- DQ2 positive which I read in a study that Iran conducted that the severity in celiac is in that gene.Im glutenfree and dealing with related issues which core issue of celiac isn't addressed. My skin, right eye, left leg diagestive issues affected. I have high blood pressure because im in pain.Im waisting my time on trying to reprove that Im celiac which is not a disease I want, but unfortunately have.It  has taken over my life personally and professionally. How do I stop getting medically gaslight and get the help needed to bounce back if I ever do bounce back to normal? I thought I was in good care with " celiac specialist " but in her eyes Im good.Im NOT.Sibo positive, IBS, Chronic Fatigue just to name a few and its all related to what I like to call a ghost disease ( celiac) since doctors don't seem to take it seriously. 
    • trents
      Celiac getting dentures

      By trents · Posted

      @Martha Mitchell, your reaction to the lens implant with gluten sounds like it could be an allergic reaction rather than a celiac reaction. It is possible for a celiac to be also allergic to gluten as it is a protein component in wheat, barley and rye.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.