Negative Dgp Igg And Negative Dgp Iga

[MoMof2Boyz]

had ds retested a few months ago, GI doc refused to do IgG versions(TtG IgG and EMA IgG) because #1 DGP IgG is negative

#2 celiac gene test came back extremely low risk

my question: since he has a low total serum IgA, should I go ahead and ask his pediatrician for IgG versions? or does his GI doc know what he's talking about? Does a negative DGP IgG and negaive DGP Iga definitley mean no celiac?

[DonnaMM]

What is a GDP test?

[MoMof2Boyz]

What is a GDP test?

mistyped it. it's DGP

[megsybeth]

MoMof2Boyz, I would keep pushing until you get all the tests if not an endoscopy (I assume there's a reason they are testing). There are many others that know much better about these tests but I happen to have been reading up about DBP IGA because that's the only test my son tested positive on (and he's "low risk" genetically, exactly as low risk as I am, with full celiac on all blood work and strong symptoms). Anyway, the DGP tests are great because they are highly SPECIFIC but not highly SENSITIVE. It's really important to know the difference because many doctors don't. With the DGP IGA, only 80% of celiacs will test positive, it's not very sensitive, but 96.5% or so who do test positive do have celiac, unlike TTG IGA which has lots of false positives, relatively.

My son's GI does not think he has it despite a highly specific test, my dx and every symptom in the book. But I'm pushing forward and waiting to get into a celiac specialist. I think you should at least get all the tests done, if not an endo.