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Interesting Article About Autoimmune Diease
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I'm not sure how popular this article is, but somebody over at another forum linked me to it. Sorry if it's old news! It give me a wealth of knowledge, that I didn't previously have. Despite tens of hours of reading about Celiacs. It explains what autoimmune disorders are, their possible causes and the links with the gut and even explains why we're sick, from a cellular level.

I did post a link, on another thread I made but the thread was about UK Dr's and fear most of you will never read it! haha

I've not quite digested it all yet. I'll need to read it a couple of times to fully understand, but it's a very interesting read. It's a huge post, so be warned. But it somehow kept my attention.

The article isn't focused on Celiacs but more on autoimmune disorders but it's very apt.

Anyway, check it out and let me know what you think. Understanding Autoimmune Diseases

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Thank you for posting this! I found it really interesting, I'm bookmarking it.

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Thanks for posting that article. I'm about halfway through it and hope to finish it up later today. Very informative. I have a lot of the signs of an autoimmune condition.

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Um... That's a really bad article. It's taking some legitimate science and spinning a ridiculous story from it. Note the complete lack of scientific references and all the scare words.

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Um... That's a really bad article. It's taking some legitimate science and spinning a ridiculous story from it. Note the complete lack of scientific references and all the scare words.

This. Also, the T cell biology is out of date and what is there is highly inaccurate. As a T cell immunologist, I am actually offended that someone wrote this article with so many inaccuracies. T cell-based autoimmunity results from inappropriate selection of immature T cells during their development in the thymus. T cells are normally selected so that they recognize but don't respond in an inappropriate way to self-proteins- T cells that respond too strongly to self-proteins are normally directed to die before they finish developing, a failsafe which is broken in people with autoimmune disease. It has nothing to do with cells in the peripheral organs not being able to signal that they are "self". I'll stop there so as not to nerd out too much, but I couldn't read on much further anyway.

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Interesting. I guess it just shows how much misinformation there is out there. This topic in particular, is proving very difficult to know what is true / false and which is out of date. Hmm

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Spend some quality time on Pubmed instead of Google. :) Pubmed is a database of peer-reviewed scientific literature run by the National Library of Medicine. It's a little harder to read, and sometimes finding a full article requires a trek to your local campus biomedical library, but more and more articles are available online for free and you can learn a fair amount just skimming abstracts. Look for review articles, as those are usually more of an overview.

http://www.ncbi.nlm.nih.gov/pubmed/

If you have something that looks really interesting and you can't quite understand it, there are enough scientists around the board that we can probably sort it out for you.

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Spend some quality time on Pubmed instead of Google. :) Pubmed is a database of peer-reviewed scientific literature run by the National Library of Medicine. It's a little harder to read, and sometimes finding a full article requires a trek to your local campus biomedical library, but more and more articles are available online for free and you can learn a fair amount just skimming abstracts. Look for review articles, as those are usually more of an overview.

http://www.ncbi.nlm.nih.gov/pubmed/

If you have something that looks really interesting and you can't quite understand it, there are enough scientists around the board that we can probably sort it out for you.

Thanks for the web suggestion Skylark! Do you have any specific articles on auto immune problems that you would recommend?

It is hard to know what really is what medically with celiac and auto immune conditions period--especially for us lay people--plus it seems difficult for many doctors. Auto immune conditions seem so counter intuitive if you get what I mean-- i.e., we have an over active immune system rather than the usual under active one when someone is not feeling well.

Bea

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I usually start searching with a phrase like maybe "autoimmunity mechanism". A list of articles will come up, many of them very detailed. On the right is a little tab where you can select review articles. Look through the reviews to find one that's free online and start reading. You will see related articles on the right too as you're browsing reviews and you can often find more interesting articles that way. At the end of every scientific article there is a reference list and nowadays they are often linked and you can read at least the abstract of things the author mentions. It IS technical, and you will learn as you go. Wikipedia is helpful sometimes, when you need to understand more biology.

You will find conflicting views, conflicting results, and a lot of questions, which is how science works. We always present the data, so that people can form their own opinions or put the data into a different context. Sometimes an experimental result doesn't make a lot of sense until years later when more is known about the immune system.

I am only really familiar with the celiac literature so I'm afraid I don't have any specific recommendations as far as autoimmune researchers to look for.

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Thanks for the web suggestion Skylark! Do you have any specific articles on auto immune problems that you would recommend?

It is hard to know what really is what medically with celiac and auto immune conditions period--especially for us lay people--plus it seems difficult for many doctors. Auto immune conditions seem so counter intuitive if you get what I mean-- i.e., we have an over active immune system rather than the usual under active one when someone is not feeling well.

Bea

Nerd alert again- a lot of why you feel sick when you have, say, a cold is due to your very active immune system spitting out inflammatory chemicals and causing tissue damage in the process of clearing the infection. And fever is actually good- it upregulates heat shock proteins that help cells recognize infection. Autoimmune cells are behaving in a similar inflammatory manner, except that there's no target infection to clear, just one's own cells.

I've also noticed from watching my grad advisor and dissertation committee members teach immunology to med students that the vast majority of med students don't give a toss about immunology beyond what they need to memorize for the test or the basics of very specific diseases. That is why so many medical doctors don't seem to have much of a clue about autoimmune disease.

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I've also noticed from watching my grad advisor and dissertation committee members teach immunology to med students that the vast majority of med students don't give a toss about immunology beyond what they need to memorize for the test or the basics of very specific diseases. That is why so many medical doctors don't seem to have much of a clue about autoimmune disease.

The vast majority of med students don't give a toss about much of anything when it comes to basic biology. It's much like working with undergraduates, where there is an unhealthy concern for what will be on the tests and things are learned by rote rather than by mechanistic understanding.

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Thanks for the article. That was easy to understand & made a lot of sense ;)

FooGirlsMom

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    • I have posted on here before. DQ2, brother with celiac, DGP iGA was the only mildly elevated test. Was gluten-free so did 6 week challenge last winter. Negative biopsy. I am gluten-free now but do go out to eat. Prior to the challenge my health was good. Since then I have: Chest pain, pain between shoulder blades, periods of shortness of breath, heart palpitations, one instance of a heart arrythmia episode, neck is tender to touch on one side (they kept saying sinuses or TMJ which my dentist vetoed) ear ache, bowels never sink. Numbness and tingling. Blood pressure variations. Could be doing chores and feel dizzy and it might be 84/52.  not super low, but not typical for me if I'm running around the house.While other days I am mildly hypertensive. Recently lost 5 lbs in 8 days without trying. Recently electrolytes were low, alkaline phosphatese was low. Ferritin started dropping so started liquid iron 2-3 times per day 4 months ago. Primary watching that, I am not anemic but we are nowhere near iron overload either.  GI doc was a dick. Did not even know DGP replaced older tests and he was very condescending When I begged him for help recently and told me to get a second opinion which is exactly what I plan on doing.  I now have pain in my upper GI area. It is tender to touch. I had my gallbladder out in 97 along with a stone and infection in my bile duct. It hurts in this area. Pancreatic enzymes look fine, liver enzymes fine. Pancreatic ultrasound fine. I will now be doing a EUS Soon to look at bile duct, pancreas and liver.   so a typical day for me is that I might feel fine for a while and then suddenly feel like I'm going to pass out. really dizzy, numbness in odd places, like my body has been hijacked. I will typically eat a bunch of food something high protein and in about an hour or so I start to feel better. However, then my upper stomach starts to hurt in place of the passing out feeling. blood sugars are also normal. After getting the " it must be panic attacks" and condescending looks a million times my primary finally ordered an ultrasound of my sore neck and there is an abnormality in my thyroid which she says looks like possibly Hashti's. Except for one time, all my serum TSH tests were normal. We have more blood work on Monday. As I have not put on any weight and there are other symptoms that are closer to Graves.  Has anyone else had any thyroid issues that followed doing a gluten challenge?  where is your stomach pain? Do you have it above or below your belly button? Mine feels like it's in the pancreas area, like 2-3 inches above the belly button and when I push on it it's tender, but not all the time. sometimes i feel it in my back. 
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