Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Interesting Article About Autoimmune Diease
0

13 posts in this topic

I'm not sure how popular this article is, but somebody over at another forum linked me to it. Sorry if it's old news! It give me a wealth of knowledge, that I didn't previously have. Despite tens of hours of reading about Celiacs. It explains what autoimmune disorders are, their possible causes and the links with the gut and even explains why we're sick, from a cellular level.

I did post a link, on another thread I made but the thread was about UK Dr's and fear most of you will never read it! haha

I've not quite digested it all yet. I'll need to read it a couple of times to fully understand, but it's a very interesting read. It's a huge post, so be warned. But it somehow kept my attention.

The article isn't focused on Celiacs but more on autoimmune disorders but it's very apt.

Anyway, check it out and let me know what you think. Understanding Autoimmune Diseases

0

Share this post


Link to post
Share on other sites


Ads by Google:

Thank you for posting this! I found it really interesting, I'm bookmarking it.

0

Share this post


Link to post
Share on other sites

Thanks for posting that article. I'm about halfway through it and hope to finish it up later today. Very informative. I have a lot of the signs of an autoimmune condition.

0

Share this post


Link to post
Share on other sites

Um... That's a really bad article. It's taking some legitimate science and spinning a ridiculous story from it. Note the complete lack of scientific references and all the scare words.

1

Share this post


Link to post
Share on other sites

Um... That's a really bad article. It's taking some legitimate science and spinning a ridiculous story from it. Note the complete lack of scientific references and all the scare words.

This. Also, the T cell biology is out of date and what is there is highly inaccurate. As a T cell immunologist, I am actually offended that someone wrote this article with so many inaccuracies. T cell-based autoimmunity results from inappropriate selection of immature T cells during their development in the thymus. T cells are normally selected so that they recognize but don't respond in an inappropriate way to self-proteins- T cells that respond too strongly to self-proteins are normally directed to die before they finish developing, a failsafe which is broken in people with autoimmune disease. It has nothing to do with cells in the peripheral organs not being able to signal that they are "self". I'll stop there so as not to nerd out too much, but I couldn't read on much further anyway.

1

Share this post


Link to post
Share on other sites




Interesting. I guess it just shows how much misinformation there is out there. This topic in particular, is proving very difficult to know what is true / false and which is out of date. Hmm

0

Share this post


Link to post
Share on other sites

Spend some quality time on Pubmed instead of Google. :) Pubmed is a database of peer-reviewed scientific literature run by the National Library of Medicine. It's a little harder to read, and sometimes finding a full article requires a trek to your local campus biomedical library, but more and more articles are available online for free and you can learn a fair amount just skimming abstracts. Look for review articles, as those are usually more of an overview.

http://www.ncbi.nlm.nih.gov/pubmed/

If you have something that looks really interesting and you can't quite understand it, there are enough scientists around the board that we can probably sort it out for you.

2

Share this post


Link to post
Share on other sites

Spend some quality time on Pubmed instead of Google. :) Pubmed is a database of peer-reviewed scientific literature run by the National Library of Medicine. It's a little harder to read, and sometimes finding a full article requires a trek to your local campus biomedical library, but more and more articles are available online for free and you can learn a fair amount just skimming abstracts. Look for review articles, as those are usually more of an overview.

http://www.ncbi.nlm.nih.gov/pubmed/

If you have something that looks really interesting and you can't quite understand it, there are enough scientists around the board that we can probably sort it out for you.

Thanks for the web suggestion Skylark! Do you have any specific articles on auto immune problems that you would recommend?

It is hard to know what really is what medically with celiac and auto immune conditions period--especially for us lay people--plus it seems difficult for many doctors. Auto immune conditions seem so counter intuitive if you get what I mean-- i.e., we have an over active immune system rather than the usual under active one when someone is not feeling well.

Bea

0

Share this post


Link to post
Share on other sites

I usually start searching with a phrase like maybe "autoimmunity mechanism". A list of articles will come up, many of them very detailed. On the right is a little tab where you can select review articles. Look through the reviews to find one that's free online and start reading. You will see related articles on the right too as you're browsing reviews and you can often find more interesting articles that way. At the end of every scientific article there is a reference list and nowadays they are often linked and you can read at least the abstract of things the author mentions. It IS technical, and you will learn as you go. Wikipedia is helpful sometimes, when you need to understand more biology.

You will find conflicting views, conflicting results, and a lot of questions, which is how science works. We always present the data, so that people can form their own opinions or put the data into a different context. Sometimes an experimental result doesn't make a lot of sense until years later when more is known about the immune system.

I am only really familiar with the celiac literature so I'm afraid I don't have any specific recommendations as far as autoimmune researchers to look for.

0

Share this post


Link to post
Share on other sites

Thanks for the web suggestion Skylark! Do you have any specific articles on auto immune problems that you would recommend?

It is hard to know what really is what medically with celiac and auto immune conditions period--especially for us lay people--plus it seems difficult for many doctors. Auto immune conditions seem so counter intuitive if you get what I mean-- i.e., we have an over active immune system rather than the usual under active one when someone is not feeling well.

Bea

Nerd alert again- a lot of why you feel sick when you have, say, a cold is due to your very active immune system spitting out inflammatory chemicals and causing tissue damage in the process of clearing the infection. And fever is actually good- it upregulates heat shock proteins that help cells recognize infection. Autoimmune cells are behaving in a similar inflammatory manner, except that there's no target infection to clear, just one's own cells.

I've also noticed from watching my grad advisor and dissertation committee members teach immunology to med students that the vast majority of med students don't give a toss about immunology beyond what they need to memorize for the test or the basics of very specific diseases. That is why so many medical doctors don't seem to have much of a clue about autoimmune disease.

2

Share this post


Link to post
Share on other sites

I've also noticed from watching my grad advisor and dissertation committee members teach immunology to med students that the vast majority of med students don't give a toss about immunology beyond what they need to memorize for the test or the basics of very specific diseases. That is why so many medical doctors don't seem to have much of a clue about autoimmune disease.

The vast majority of med students don't give a toss about much of anything when it comes to basic biology. It's much like working with undergraduates, where there is an unhealthy concern for what will be on the tests and things are learned by rote rather than by mechanistic understanding.

1

Share this post


Link to post
Share on other sites

Thanks for the article. That was easy to understand & made a lot of sense ;)

FooGirlsMom

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      103,918
    • Total Posts
      919,627
  • Topics

  • Posts

    • Weird things people have said
      I've had people say strange things about celiac to me lately... Like someone said, "Oh I'm just a mild celiac so I don't have to worry about cross-contamination." And then someone else said that they're celiac but things have calmed down now so they can have a bit of gluten here and there. And I told my doctor that back in 2014 I thought I had been gluten free but I actually wasn't because I had been repeatedly glutening myself with an old colander. And he just looked at me like I was insane, like a colander?? Sure... I'm not crazy, right? Even if you have no symptoms you have to avoid cross-contamination because you can be doing damage internally right? You can never have 'just a bit'. And a colander is a big source of cross-contamination right?? I know all this but why do these other people not? Why does my doctor not know? So confusing and spreading misinformation... And then they look at me like *I'M* crazy.
    • fructose malabsorption and gluten intolerant
      Look up FODMAPS.   That might clarify things for you.  There really are a lot of diet recommendations so make sure you bring a list of questions regarding foods to your doctor's  and dietician's appointments.  
    • Recovery?
      Thank you for sharing those web sites. I will look at them. We have been gluten free since December so it's been a while. Once, he had a gluten free beer, the kind that they take the gluten out, and his legs felt very heavy and had a more difficult time walking. I really don't want to experiment.  Although I am very careful about what we eat, I am concerned that some of our medication could contain gluten. Is there any easier way to tell if medication has gluten. I did find a website which listed drugs and known gluten but every drug was on it or was determined to be gluten free
    • fructose malabsorption and gluten intolerant
      I don't have celiac but doctors or amazed I don't so they told me to fallow the gluten-free diet like I have it... any way I was wondering if one can have corn, corn starch if they have fructose malabsorption. I am so confused on what I can and can't have.. i have an appt next week hopefully with a dietitian... also can you have sugar free stuff since it's not sugar.. I'm reading online and I'm getting a bunch of mixed info on both. 
    • Depression / anxiety issues
      Hi all.  Still feeling the same way this past week. I'm thinking of dropping dairy starting from today, I don't know if I have a problem with it or not, but I drink 2 coffees a day with milk. I'm just constantly tired all the time, and getting trough the day is pretty hard, I noticed a couple of weeks ago that my sleep was improving but the last couple of days I have been waking up at least 3 times during the night, then when I get up in the morning it feels like I have been hit by a bus, like I haven't slept at all. I keep waking up during the night needing to drink water as I feel dehydrated, I don't know why as I drink 2-3 litres of water everyday 
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

    • Jmg  »  admin

      Hello Admin!
      I don't know whether this is of interest to post on your articles feed:
      http://pratt.duke.edu/about/news/window-guts-brain
      Kind Regards,
      Matt
      · 2 replies
    • celiac sharon  »  cyclinglady

      Hello cycling lady, have you noticed my picture is showing up as you?  Have no idea why but it's rather disconcerting to see my picture and your words 😉  Do you know how to fix it?  You seem to have far more experience with this board than I do
      · 1 reply
    • Larry Gessner  »  cyclinglady

      Hi There, I don't know if there is a place for videos in the forum. I just watched "The Truth About Gluten" I think it is a good video. I would like to share it somewhere but don't know where it should go. Any help would be greatly appreciated.
      Here is the link if you have never watched it.
      https://youtu.be/IU6jVEwpjnE Thank You,
      Larry
      · 2 replies
  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      60,962
    • Most Online
      1,763

    Newest Member
    Ktowncaroline
    Joined