No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

High Incidence of Celiac Disease in a Long-term Study of Adolescents with Susceptibility Genotypes


Photo: CC-- Gordon

Celiac.com 03/20/2017 - Researchers really do not have really good data on rates of celiac disease in the general population of children in the United States. A team of researchers recently set out to estimate the cumulative incidence of celiac disease in adolescents born in the Denver metropolitan area.

The research team included Edwin Liu, Fran Dong, MS, Anna E. Barón, PhD, Iman Taki, BS, Jill M. Norris, MPH, PhD, Brigitte I. Frohnert, MD, PhD, Edward J. Hoffenberg, MD, and Marian Rewers, MD, PhD.

Their team collected data on HLA-DR, DQ genotypes of 31,766 infants, born from 1993 through 2004 at St. Joseph’s Hospital in Denver, from the Diabetes Autoimmunity Study in the Young. For up to 20 years, the researchers followed subjects with susceptibility genotypes for celiac disease and type 1 diabetes for development of tissue transglutaminase autoantibodies (tTGA).

The team was looking for patients who developed either celiac disease autoimmunity (CDA) or celiac disease, and they defined CDA as persistence of tTGA for at least 3 months or development of celiac disease. Marsh 2 or greater lesions in biopsies or persistent high levels of tTGA, indicated celiac disease.

Ads by Google:

For each genotype, the team assessed cumulative incidence of CDA and celiac disease. To estimate the cumulative incidence in the Denver general population, they weighted outcomes by each genotype, based on the frequency of each of these genotypes in the general population.

They found that, of 1.339 patients they studied, 66 developed CDA and met criteria for celiac disease, while 46 developed only CDA. Seropositivity for tTGA resolved spontaneously, without treatment, in 21 of the 46 patients with only CDA (46%). The team estimated the total incidence for CDA in the Denver general population at 5, 10, and 15 years of age was 2.4%, 4.3%, and 5.1% respectively; incidence values for celiac disease were 1.6%, 2.8%, and 3.1%, respectively.

This 20-year prospective study of 1.339 children with genetic risk factors for celiac disease showed the total incidence of CDA and celiac disease to be high within the first 10 years.

Although more than 5% of children may experience a period of CDA, that is, persistently high celiac autoantibodies, not all of them develop celiac disease or require gluten-free diets.

Sources:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


That's terrible. I've been wondering why you haven't been around last few days. I Should have remembered your con. I'm so sorry it wasn't what you were hoping for. We all tend to make mistakes when we're excited about stuff, makes our brains go a bit wonky. hope your dads mouth wasn't dirty ...

Yum, what's wrong with eggs and bacon? i just got some gluten-free granola yesterday that I tried this morning and it's not too bad but it's got gluten-free oats. Can you do oats?

Before being diagnosed I was almost a 100% Raisin Brain cereal eater. So I switched to Bakery on Main, Gluten Free Granola. I was having nausea, lose stool, and would get dizzy about 30 min. after eating it. Doc said to switch to Soy milk. That didn't really help either. Now I just put...

My Dr. also said that about thyroid! The appt went well. She is sending me for endoscopy and colonoscopy. She said to eat gluten one week before, which according to everything else, is not correct. My concern now is this- I didn't eat much anyhow, but I can't imagine eating 4 pieces o...

Hi, everyone. I haven't been diagnosed with Celiac disease, so I hope it's okay for me to post here. I'm a 21-year-old female who has been struggling with some chronic symptoms for about a year now. Out of nowhere, I started losing weight. To date, I've lost upwards of 70 pounds. I was ...