Emerging Celiac Disease Treatments: Will Any Allow Gluten Consumption Again? (+Video)

I am glad that there are so many things that are so many studies out there.

I thought that CNP-101, or TAK-101 was already in phase 2 studies. Also, I have read some conflicting comments that KAN-101 was very recently terminated early, even though it has shown very promising results. A participant was told that they are losing too much funding from our current administration (which is absolutely abhorrent). Does anyone know what the real story is? 

I find it rather annoying to see the "1% of the global population," endlessly repeated when the latest study out of Italy puts it at 1.6%.  Why are we downplaying our own importance here?

"An Italian study found that 1 in every 60 children has celiac disease, a rate higher than expected. The study, led by Elena Lionetti, conducted a mass screening of children age 5-11 from eight different Italian provinces and found the overall prevalence of celiac disease to be 1.6%, a much greater percentage than previously thought."

You bring up a valid and important point. The persistent citation of the "1% of the global population" figure can indeed feel outdated, especially when newer, well-conducted studies like the one from Italy suggest that the actual prevalence—particularly in children—may be significantly higher. The Italian study by Elena Lionetti showing a 1.6% rate in screened children highlights how undiagnosed celiac disease still is, and that mass screenings reveal a more accurate picture than symptom-based diagnoses alone. However, more studies are needed to confirm that the overall global prevalence is higher than 1%, which is why the default level cited is still 1%.

How about we turn the tables and start using the 1.6% until that is challenged with these so called "needed" studies?  I for one feel trust Elena Lionetti's study.  It was a mass screening and no one is contesting it so why not go with that?  If there are doubters out there they can cough up the research dollars to prove otherwise.  We should not be voluntarily downplaying ourselves.  It's absurd.

It is a single study done on children within a single country in Europe, so it's results can't be projected onto the entire world for both adults and children, and over all ethnic groups in the world. The 1% figure is an approximation based on the results of many studies that have been done worldwide on both adults and children.

We know that many of those studies are outdated.  The prevalence of new testing capabilities is continually changing the landscape.  And as you say it's an approximation, not gospel.  The real number is unknown and may never be known.  Are we all so complacent that we are just going to keep echoing the 1% figure?  Why aren't we elevating Lionetti's study instead of treating it like a quaint anecdote?  No one in any other country, anywhere in this world benefits from a lesser number.  What if the prevalence of this disease is 1.9% in say Lithuania?  Or 2% in Kentucky?  There may never be conclusive testing done in either place.  The 1% figure is just as much a projection as the 1.6% would be.  Furthermore, if the 1% is supposed to factor in this multiplicity of studies, it should now include the results of Lionetti's study.  Surely her study would increase the percentage by something!  

I have mixed feelings about this.  A total “cure” would be optimal, but anything less might dilute the current market influence for gluten-free foods that Celiac and gluten-intolerance sufferers have now, with products and restaurants offering gluten free foods, and food testing required for certified gluten free labeling.   I also fear that as with any medications, the list of side effects might be unacceptable to some or many and yet it will be perceived that every Celiac sufferer should just take a pill.  Those who might choose not to take medication might be treated harshly, and we might return to the days of just eat what you are given and don’t complain.  

Marish makes a good point. Even if there is an effective "pill" therapy developed, how expensive will it be and will insurances cover it?

When I was diagnosed in 2013, I did some research and came across an article from the Mayo Clinic. It suggested that approximately 40% of the global population was walking around with undiagnosed Coeliacs or, some level of Gluten Intollerance.

My Brother, exihibits the same external and Endocrynic patterns as I do, but! insists he is not a Coeliac and refuses to get tested; he added, even if he is, at his age, he has zero intention of changing his diet because he has tried my Gluten Free menu and was like, yeah, nah, not ever going to do that.

It's not to far a stretch to imagine the Mayo Clinic's revalation, (given the amount of garbage manufacturing companies put in our foods and liquids [Fluoride], [Propyline Glycol]) that their figure will become a reality.

CNP-101 sounds the most promising, I hope i'm still here in 2030 to see it come to fruition.

Footnote:

Australia has a much stricter definition of the term "Gluten Free", it's marker is 20 parts per Million, whereas, many other countries use 40 parts; we also label Oats as "Wheat Free", not "Gluten Free". the consumption of Oats has always been a hot topic of conversation. Coeliac.org cites that any consumption needs to be clinically monitored by your Endocrinologist to ensure you're not doing damage.

@N00dnutt, can you find that article from the Mayo Clinic? That one would be a handy one to have for education purposes.

Hi @trents. Apologies, I did a search for the article and cannot find it. Given it was a generalised comment in the article, it could have been removed as no citations could be applied to it.
I did find this other article produced more recently that does not surprise me, given the data it presents.
https://celiac.org/wp-content/uploads/2018/06/Global-prevalence-of-celiac-disease_GGH_2018.pdf

This Extract shows global preverlance for celiac disease, not surprising, Australia has 51-75%, shockingly, South America is 76-100%, that concerning:

Hi @trents. Apologies, I did a search for the article and cannot find it. Given it was a generalised comment in the article, it could have been removed as no citations could be applied to it.
I did find this other article produced more recently that does not surprise me, given the data it presents.
https://celiac.org/wp-content/uploads/2018/06/Global-prevalence-of-celiac-disease_GGH_2018.pdf

This Extract shows global preverlance for celiac disease, not surprising, Australia has 51-75%, shockingly, South America is 76-100%, that concerning:

Some information as to how the data was put together.