IgA deficiency

[Thrillrose]

Hello, 

Two of my children have been diagnosed with coeliac disease. I was tested as well and my TT IgA and deamidated gliadin were both normal but the IgA was deficient. 

My dr said that doesn't mean much. But then my sister was tested and her result was the same as mine! Her dr told her to cut out gluten as she obviously has a reaction to it. 

And then of course I start googling and find out that her dr seems to be correct. And that if we don't cut out gluten now, coeliac disease may develop. 

Does anyone know any more about this??

 

thanks 

 

 

 

[cyclinglady]

If you are iga deficient, then any of the iGA-based celiac tests (e.g. DGP Iga or TTg iga) are invalid.  Your doctor can order other celiac antibody tests: EMA or the tTG IgG or DGP IGG).  It sounds like your doctor only ordered then iga versions.  Not good, in your case because of your igA defciency.  

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Welcome to the forum!  

 

 

[Nolev]

Totally agree with cyclinglady. I am IgA deficient as well. Scores a healthy zero on the IgA based tests - false negative as it turns out. Finally got the TTG-IgG version and voila I broke the test - really. >15 was positive for celiac and I had >250!! IgA deficiency is genetic. You need to follow this chart and you can see clearly what tests you need. Good luck. Open Original Shared Link

[Nolev]

Oh and let me clarify - based on the tests you say you had you only know you are IgA deficient. You have no information on your celiac diagnosis until you take the IgG versions. Then you will know if you likely have celiac or not. Next step would be endoscopy. If you have celiac, you need to be gluten-free for life. You don't develop celiac by eating gluten. You simply get much much worse and proceed to damage your intestines and put yourself at risk for other diseases such as lymphoma and diabetes. You would already have celiac if the TTG-IgG test comes back positive, if that makes sense. Then the gluten-free diet reverses the symptoms. Hope that helps clarify 

[Thrillrose]

Great info! Thanks so much. 

[Irene Joanne]

I am deficient in IGA- thankfully the lab that processed my lab work- also did the IgG blood work. This was positive as well as the biopsy.