Worth pursuing further or negative?

[DASHER3]

Hi! I will give you a quick rundown. I have had issues for over 10 years now with joint pain, extreme fatigue, canker sores, and headaches. I have had bloodwork down countless times with no answers. At one point I had a positive ANA but was never referred for further testing but my most recent test was negative. I have a history of elevated unexplained bilirubin. I had a liver ultrasound and all looked fine. Up until this point I was not tested for celiac but over the past few months my symptoms have become so severe, my joint pain and weakness is so bad some days I cannot function. Tests were neg for rheumatoid arthritis. I just got my test results back but no call from the doctor so I'm not sure what to take away except what Google tells me. I am so beyond frustrated and just want to give up. At this point I feel like I'm crazy because I was so sure this was going to be my answer. So my question, should I have my doctor run anything else since my IGA was flagged low or does the neg gliadin IGG ab confirm no celiac?  Any insight? 

 

Component	Your Value	Standard Range	Flag
GLIADIN IGA AB (DEAMIDATED)	4.1 UNITS	<20 UNITS
NEGATIVE
GLIADIN IGG AB (DEAMIDATED)	2.3 UNITS	<20 UNITS
NEGATIVE
TISSUE TRANSGLUTAMINASE IGA AB	2.8 UNITS	<20 UNITS
NEGATIVE
IGA	68 mg/dL	70 - 400 mg/dL	L

[cyclinglady]

On 4/6/2018 at 1:10 PM, DASHER3 said:

Hi! I will give you a quick rundown. I have had issues for over 10 years now with joint pain, extreme fatigue, canker sores, and headaches. I have had bloodwork down countless times with no answers. At one point I had a positive ANA but was never referred for further testing but my most recent test was negative. I have a history of elevated unexplained bilirubin. I had a liver ultrasound and all looked fine. Up until this point I was not tested for celiac but over the past few months my symptoms have become so severe, my joint pain and weakness is so bad some days I cannot function. Tests were neg for rheumatoid arthritis. I just got my test results back but no call from the doctor so I'm not sure what to take away except what Google tells me. I am so beyond frustrated and just want to give up. At this point I feel like I'm crazy because I was so sure this was going to be my answer. So my question, should I have my doctor run anything else since my IGA was flagged low or does the neg gliadin IGG ab confirm no celiac?  Any insight? 

 

Component	Your Value	Standard Range	Flag
GLIADIN IGA AB (DEAMIDATED)	4.1 UNITS	<20 UNITS
NEGATIVE
GLIADIN IGG AB (DEAMIDATED)	2.3 UNITS	<20 UNITS
NEGATIVE
TISSUE TRANSGLUTAMINASE IGA AB	2.8 UNITS	<20 UNITS
NEGATIVE
IGA	68 mg/dL	70 - 400 mg/dL	L

In the case of celiac disease testing, the Immunoglobulin A (IgA) is used as a control test (to see if the IgA celiac test work).     Your result is just out of range, but it is valid for celiac testing.  Keep in mind that some celiacs are seronegative, if the GI suspects celiac disease you would proceed to biopsy via endoscopy.  

You might not have celiac disease, but a gluten sensitivity.  That means no intestinal damage, but many of the same symptoms.  There is no testing for a gluten sensitivity, but you can trial the gluten-free diet for six months to see if you improve.  Consider the AIP (Autoimmune paleo) diet as well.  In small studies it has been show to be effective in putting patients (specifically IBD patients) in remission.  

I hope you feel better soon.