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What do these mean?!

TWilson9608
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TWilson9608 Newbie
TWilson9608
Posted

Hello. My youngest daughter (8 y/o) was recently diagnosed with Celiac Disease, thorough labs and biopsies. It was suggested that our who family be tested and so I immediately began that process. My middle daughter (15 y/o) labs came in with a positive IGA of 13 but the transgluten was negative. What could this mean? My middle daughter is being referred to the pros GI specialist that my youngest goes to but her pediatric doctor is running a great deal more labs to look into other autoimmune disorders as well. I am being told, regardless of the negative portion that she does have Celiacs and obviously they'll need to confirm with biopsies, but both the labs and the pediatrician say its celiac...Can anyone clarify this more for me because I can't seem to find the correct search online to find the answers that I am looking for and my anxiety is through the roof right now! TIA

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cyclinglady Grand Master
cyclinglady
Posted
8 minutes ago, TWilson9608 said:

Hello. My youngest daughter (8 y/o) was recently diagnosed with Celiac Disease, thorough labs and biopsies. It was suggested that our who family be tested and so I immediately began that process. My middle daughter (15 y/o) labs came in with a positive IGA of 13 but the transgluten was negative. What could this mean? My middle daughter is being referred to the pros GI specialist that my youngest goes to but her pediatric doctor is running a great deal more labs to look into other autoimmune disorders as well. I am being told, regardless of the negative portion that she does have Celiacs and obviously they'll need to confirm with biopsies, but both the labs and the pediatrician say its celiac...Can anyone clarify this more for me because I can't seem to find the correct search online to find the answers that I am looking for and my anxiety is through the roof right now! TIA

Which IgA was it (and the lab range)?

  • Anti-tissue transglutaminase (tTG)
  • Anti-endomysium (EMA)
  • Anti-deamidated gliadin peptides (DGP)

It only takes one positive on any of these three tests to further investigate (e.g. biopsies via endoscopy).  

TWilson9608 Newbie
TWilson9608
Posted
  • Author
(edited)

Celiac IGA Gliadian Deamidatedb13

IGA Transglutamainase 0.3

Edited by TWilson9608
cyclinglady Grand Master
cyclinglady
Posted

Okay, the information based on what you provided earlier (13 positive) seems to indicate that she needs to be elevated by a Gastroenterologist.  She has a positive on the DGP IgA, which is like me.  I have never had a positive on the EMA or the TTG even in follow up testing. The celiac tests are not perfect.  It is one reason why there are several.  Do not let your screening doctor (maybe your PED) tell you that she is not positive because she did not get a positive on the TTG.  

  It is a lot to take in, but knowing a diagnosis is so important.  Hang in there.  I get it.  I have a daughter too!  

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