Solanine and Nickel

[knitty kitty]

Solanine and Nickel was brought up in another post.  I thought a continuation of the discussion in its own thread would be beneficial.  

Solanine is a glycoalkaloid present in nightshades (tomatoes, potatoes, eggplants and peppers). 

 

"Naturally occurring glycoalkaloids in potatoes aggravate intestinal inflammation in two mouse models of inflammatory bowel disease"

https://pubmed.ncbi.nlm.nih.gov/12479649/

 

"Risk assessment of glycoalkaloids in feed and food, in particular in potatoes and potato‐derived products

EFSA Panel on Contaminants in the Food Chain (CONTAM)"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417869/#!po=0.0880282

 

Intestinal permeability can lead to Small Intestinal Bacterial Overgrowth....

"The Relationship between Small-Intestinal Bacterial Overgrowth and Intestinal Permeability in Patients with Irritable Bowel Syndrome"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852716/#:~:text=Small-intestinal bacterial overgrowth (SIBO,inflammation in the intestinal mucosa.

 

"Small intestinal bacterial overgrowth syndrome"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890937/#!po=0.505051

 

Small Intestinal Bacterial Overgrowth is common in Celiac Disease.

SIBO causes absorption problems.  Those SIBO bacteria are competing with you for those nutrients, vitamins and minerals you eat, causing deficiencies....

 

"Nutritional consequences of intestinal bacterial overgrowth"

https://pubmed.ncbi.nlm.nih.gov/7805370/#:~:text=Clinically%2C patients present with nonspecific,%2C fat malabsorption%2C and malnutrition.

 

"Thiamine Acquisition Strategies Impact Metabolism and Competition in the Gut Microbe Bacteroides thetaiotaomicron"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613172/

 

Which came first? The chicken or the egg?

"SIBO, IBS, and Constipation: Unrecognized Thiamine Deficiency?"

https://www.hormonesmatter.com/sibo-ibs-constipation-thiamine-deficiency/

 

"Thiamine Deficiency - A Potential Cause of SIBO and other Gut Dysfunction?"

https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo#:~:text=Thiamine deficiency reduces brush border,liver%2C kidney%2C and heart.

 

 

Why thiamine is important in the discussion about Solanine....

"Sulfur compounds reduce potato toxins during extrusion cooking"

https://pubmed.ncbi.nlm.nih.gov/11409974/

Thiamine contains these sulfur compounds that get rid of the alkaloids in nightshades.

And where does nickel come in?

Thiamine can cheated those pesky heavy metals like arsenic, lead, mercury, nickel, etc...

 

"Influence of thiamine and ascorbic acid supplementation on the antidotal efficacy of thiol chelators in experimental lead intoxication"

https://pubmed.ncbi.nlm.nih.gov/3240094/

 

"Utilize thiamine disulfide chelating agent to handle the method for heavy metal in the waste water"

https://patents.google.com/patent/CN1069008A/en

 

Autistic children have high levels of heavy metals....

 

"Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study"

https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/1020278

 

About TTFD: A Thiamine Derivative"

https://www.pnas.org/content/115/42/10532

 

Seems there's a thiamine deficiency worldwide.....

"News Feature: Deadly deficiency at the heart of an environmental mystery"

https://www.pnas.org/content/115/42/10532