Is Lactose Intolerance, In Part, responsible for Refractory Celiac Disease?

[Posterboy]

To All,

I came across some research on Lactose intolerance as  trigger for a Celiac diagnosis in a Gluten Free eating person recently.

And it got me thinking could the approx. 40 Percent of Celiac's patient not responding to a gluten free diet really be Lactose Intolerance instead.

Here is the article on Refractory Celiac disease in those Celiac's patients whose disease is not well controlled on a gluten free diet.

Then I found this research that shows Lactose (really Casein probably) can be the trigger for a Celiac diagnosis in someone who is Lactose Intolerant.

See this thread where I note certain connections in Celiac disease that people have not put 2 + 2 together (yet) to notice these connections.

 

Here is the Abstract on this topic entitled "[Anti-tissue transglutaminase antibodies not related to gluten intake]" from Cows Milk Protein...Instead.

https://pubmed.ncbi.nlm.nih.gov/29555204/

From the linked thread on Refractory Celiac disease.....so I won't have to type it all again...

I will quote the full abstract for those who might be following this.

Abstract

"Introduction: Anti-tissue transglutaminase antibodies (tTG) have high specificity for coeliac disease (celiac disease). However, positive anti-tTG antibodies have been described in non-coeliac patients. Aim To assess positive anti-tTG antibodies not related to gluten intake.

Patients and methods: Retrospective review and follow up conducted on patients with suspected celiac disease (increase anti-tTG levels and gastrointestinal symptoms) but with atypical serology results, positive anti-tTG with gluten free diet and a decrease in anti-tTG levels despite gluten intake.

Results: A total of 9 cases were reviewed in which 5 cases had Marsh 3 involvement in the initial biopsy, and were diagnosed with celiac disease (Group A). They began a gluten free diet and also a cow's milk protein (CMP) free diet because of their nutritional status. When CMP was re-introduced, anti-tTG increased, and returned to normal after the CMP was withdrawn again. The other 4 patients had a normal initial biopsy (Group B). Gluten was not removed from their diet, but they started a CMP free diet because a non IgE mediated CMP allergy was suspected. Symptoms disappeared, and anti-tTG was normal after CMP free diet with gluten intake. All the patients had susceptibility haplotype HLA DQ2/DQ8.

Conclusions: CMP ingestion after an exclusion diet can induce an increase in anti-tTG in some coeliac subjects. CMP can produce this immune response if there were no gluten transgressions. This response has also been observed in non-IgE mediated CMP allergy patients with the susceptibility haplotype HLA DQ2/DQ8."

IF you know it wasn't the gluten then Milk/Dairy is the next logical thing to removed from your diet!

And there should be more awareness of this connection and why I started this thread so people can reference it in the future.

Often 44% is quoted as the percent a first degree relative might have of going on to develop Celiac disease when one relative has it....

This possibility of Casein Protein also triggering a Celiac diagnosis explains this figure/connection nicely!

We also know becoming low in Thiamine can trigger thin our villi and trigger a Lactose Intolerance in the process .  It is an Elegant Theory!

I would love to hear other's people's insights and opinion's on this exciting research.

IF this is true then It (removing Dairy/Lactose/Caseins from their diet) could really help those Refractory Celiac disease still suffering from an unknown cause such as removing Dairy (Casein) from their diet to see if their Refractory Celiac disease doesn't THEN get better.

The above research PROVES IT is happening.  And 40 Percent is a common rate for whic Lactose Intolerance occurs, at least in part, in certain ethnicity's???

Is this also happen in Celiac patients at  a similar rate the Doctor's haven't figured this out yet???

I hope this is helpful but it is not medical advice.

Posterboy,

[Scott Adams]

It's definitely a possible explanation. Good work putting this info together and making the connection.

[GodsGal]

Interesting to think about. There could be a connection.

[Posterboy]

On 5/27/2021 at 7:33 PM, Scott Adams said:

It's definitely a possible explanation. Good work putting this info together and making the connection.

Scott,

 I would write a Posterboy blog post about this association / connection / relationship if I  had the time.....but what really needs to be done is an article written about it on Celiac.com

You do good summary's....

Why this isn't on the front page of every news paper in the USA/World??? I will never know!

Lactose intolerance is being Diagnosed, in some Celiac's at least, (I have learned to say over the years, in part)....this is ground breaking research!!!

IT explains why not ALL Celiac's respond to a gluten free diet perfectly....

Because other things IE food allergens in one diet like Casein / Lactose is also triggering the same reaction in Celiac's.

It explains the 40% Percent of Celiac's almost to a "T" that don't get better on a Gluten Free diet, alone.

I once wrote a prose piece about this called "Gluten Juneteenth"......other's need to hear/know/understand that NCGS can be triggered by Dairy/Lactose (Casein) really in their diet!

And Celiac.com IS where they need to read it.....

It takes time for people to digest new information.....but if no body ever talks about it....

NO change ever happens.....You (Celiac.com) can help people  TODAY by telling them NCGS can be triggered in 40 Percent of Celiac's..... a gluten like reaction from Casein/Lactose in their diets....

It IS too good of research to be ignored.....

But I sure wish more doctor's new about this connection / Association.

IT can help people today.....while it takes another 15 to 20 years for the doctor's to accept it and adopt it as  medical fact.

As I said in another prose piece once.....When Medical Myth becomes medical fact.....people suffer unnecessarily....and I believe this is what is happening here!

It is a medical fact....that Casein is triggering a reaction being diagnosed in Celiac's as refractory Celiac disease....but because this research has been ignored for 2+ years already then the doctor's and their Celiac patients are not aware of this connection.

Celiac.com can raise the awareness factor by doing an article about this connection / association!

So it doesn't stay hidden for another 15 to 20  years!!!

As always I hope this is helpful but it is not medical advice.

2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the Grace of God,

[Jackie Garrett]

On 5/31/2021 at 9:25 PM, Posterboy said:

Scott,

 I would write a Posterboy blog post about this association / connection / relationship if I  had the time.....but what really needs to be done is an article written about it on Celiac.com

You do good summary's....

Why this isn't on the front page of every news paper in the USA/World??? I will never know!

Lactose intolerance is being Diagnosed, in some Celiac's at least, (I have learned to say over the years, in part)....this is ground breaking research!!!

IT explains why not ALL Celiac's respond to a gluten free diet perfectly....

Because other things IE food allergens in one diet like Casein / Lactose is also triggering the same reaction in Celiac's.

It explains the 40% Percent of Celiac's almost to a "T" that don't get better on a Gluten Free diet, alone.

I once wrote a prose piece about this called "Gluten Juneteenth"......other's need to hear/know/understand that NCGS can be triggered by Dairy/Lactose (Casein) really in their diet!

And Celiac.com IS where they need to read it.....

It takes time for people to digest new information.....but if no body ever talks about it....

NO change ever happens.....You (Celiac.com) can help people  TODAY by telling them NCGS can be triggered in 40 Percent of Celiac's..... a gluten like reaction from Casein/Lactose in their diets....

It IS too good of research to be ignored.....

But I sure wish more doctor's new about this connection / Association.

IT can help people today.....while it takes another 15 to 20 years for the doctor's to accept it and adopt it as  medical fact.

As I said in another prose piece once.....When Medical Myth becomes medical fact.....people suffer unnecessarily....and I believe this is what is happening here!

It is a medical fact....that Casein is triggering a reaction being diagnosed in Celiac's as refractory Celiac disease....but because this research has been ignored for 2+ years already then the doctor's and their Celiac patients are not aware of this connection.

Celiac.com can raise the awareness factor by doing an article about this connection / association!

So it doesn't stay hidden for another 15 to 20  years!!!

As always I hope this is helpful but it is not medical advice.

2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the Grace of God,

I absolutely 100% agree, I believe sadly, that lactose/casein could be the underlying cause of these gluten intolerances. But I know how to get myself better by avoiding milk, such a shame as I have always loved dairy but it doesn’t love me. It took me years to work this out because we’re always told how good it is for us so I never thought it possibly could be milk, I feel a sigh of relief that I now know the reason and can get on with life. But I had to work this out for myself nobody told me, it’s not out there enough, I believe we all have our limitations with Lactose. Such a shame it’s in so many things that we are ingesting that you wouldn’t even think it would be in, it’s not on the labels, but I hope this soon changes.