High Gliadin IgA numbers after Covid

[ffordbush]

I have been following a strict gluten free diet and had Covid two weeks ago...one week ago I had bloodwork done and the doctor called and said that my numbers were off the charts.  I have examined everything I have eaten and there is nothing with gluten.  Is it possible that Covid skewed the numbers?  I see there are studies regarding people testing positive for celiac after covid so it would stand to reason that it might skew the numbers.  Just want to know if anyone else has experienced this?

[trents]

Since your original bloodwork and diagnosis, have you had any celiac antibody tests done pre covid? In other words, since the original celiac diagnosis and going gluten free but before covid, do you have any recent antibody test numbers to compare your post covid numbers to?

Edited February 23, 2024 by trents

[ffordbush]

6 minutes ago, trents said:

Since your original bloodwork and diagnosis, have you had any celiac antibody tests done pre covid? In other words, since the original celiac diagnosis and going gluten free but before covid, do you have any recent antibody test numbers to compare your post covid numbers to?

Yes, I had my numbers done in October and they were fine.  I was diagnosed Celiac in 2020 so I finally got my numbers down until this.

[trents]

Then it seems reasonable to me to assume your recent elevated numbers were caused by COVID. But I would certainly have them checked again within a few months. Having said that, can you be more specific about which antibody numbers were elevated? There are a number of antibody tests that can be run to detect celiac disease. Some are more specific to celiac disease than others and some are more sensitive than others. Can you post results pre COVID and post COVID along with reference ranges for negative vs. positive? Also, do know if the same lab was used to evaluate the blood samples post COVID as was used pre COVID. There are no industry standard reference ranges for these tests so looking at different results from different labs can be deceiving.

[ffordbush]

All of them were done at Mayo. prior and current.

Gliadin (Deamidated)Ab, IgA, S  >150 Normal Value <20.0 Interpretation Positive (>30.0)

Gliadin (Deamidated) Ab, IgG, S <10 Normal Value <20.0 (Negative) U

Tissue Transglutaminase Ab, IgA, S 13.3 Normal Value: <4.0 (Negative) U/mL

[trents]

You do not give before COVID and after COVID numbers to compare. Is what you posted from October or after COVID? 

Edited February 23, 2024 by trents

[Scott Adams]

If you're certain that your diet has been 100% gluten-free, and the only thing that changed after your last test is your recent bout with Covid-19, it seems possible that it could be related, but I've not seen specific research that indicates a connection between covid-19 causing elevated antibody levels. 

For some people there are other conditions that can cause elevated Tissue Transglutaminase IgA Antibodies (tTG-IgA). This article discusses them:

 

 

[ffordbush]

2 hours ago, trents said:

You do not give before COVID and after COVID numbers to compare. Is what you posted from October or after COVID? 

Sorry about that, one week after covid.

[trents]

So, DGP-IGA is postitive at 130, DGP-IGG is negative at <10 and tTG-IGA is positive at 13.3.

Now, can you give us the same test results from October so we can compare numbers?

[knitty kitty]

@ffordbush,

Are you consuming dairy?  Has your dairy intake changed before or after having Covid?

[ffordbush]

37 minutes ago, knitty kitty said:

@ffordbush,

Are you consuming dairy?  Has your dairy intake changed before or after having Covid?

Dairy has been the same.

[knitty kitty]

@ffordbush,

Try cutting out dairy and see if your antibodies go down.  

Some people react to dairy as though it were gluten because casein (the protein in dairy) resembles gluten (the protein in wbr).  

 

Mucosal reactivity to cow's milk protein in coeliac disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810502/

[Wheatwacked]

Has your vitamin D level been tested?

"A strong significant inverse association was observed between tTG antibody levels and serum 25(OH)D... participants with positive IgA tTG antibodies was 37.2 times higher for participants with 25(OH)D < 12.5 nmol/l than those whose vitamin D status was higher "

Celiac disease and severe vitamin D deficiency: the case for anti-tissue transglutaminase antibody screening

Converting 12.5 nmol/L to ng/ml equals 5 ng/ml.  Severe vitamin D deficiency.

Literally thousands of articles and studies on vitamin D and disease have been done.  Most find a correlation between low vitamin D and high inflammation.  Does the disease cause the low D or does low D cause the disease?

Considering that since our lives have been increasingly indoors since the Industrial Revolution and since around 1970 when outdoors we are encouraged to use extreme measures to avoid UV-B, my opinion is that poor vitamin D compromises the immune system allowing the diseases to increase unimpeded.  More profit for the pharmaceuticals.

• In 2016, about 6,800 Canadians were diagnosed with melanoma and 1,200 will die from it. 
• It is estimated that more than two million Canadians are affected by autoimmune diseases.
• Estimated that 40 to 70% of Canadians has low vitamin D
•  According to the American Cancer Society, cutaneous melanoma was the fifth most common cancer in 2022, with an estimated 99,780 new cases and 7,650 deaths. 
• 50 million Americans have one or more autoimmune diseases.
• Estimated that 42% of US, Irish and UK adults have low 25(OH)D

[ffordbush]

Thank you for this, I will try cutting out dairy and see if my numbers go down.