Weak positive anti-ttg igA?

[Jesmar]

Hi all. 

I am an 18 year old male. Recently I had anti ttg-igA tested and it came back as 9.1 IU/ml (weak positive) (increased from previous test which was 5.6iU/mL) . What does this mean please? I am booked for an endoscopy however, i am negative for both HLA DQ2 and DQ8. I have a family history of coeliac. 

[trents]

Welcome to the forum community, @Jesmar!

The HLA DQ2 and DQ8 genes were the original halotypes identified with the potential to develop celiac disease. Since then, other genes have been discovered that apparently afford a predisposition to celiac disease. As is always the case, these new discoveries are not yet common knowledge and not yet widely dispersed in the medical community. It is not genetically as black and white as we once thought.

[Jesmar]

Very true. I also suffered from candidiasis which had affected my intestines and toes. I think this might have triggered my gluten intolerance/celiac.

[Scott Adams]

Be sure to keep eating gluten daily until all testing is completed. 

Here is more info about how to do a gluten challenge for a celiac disease blood panel, or for an endoscopy:

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"...in order to properly diagnose celiac disease based on serology and duodenal histology, doctors need patients to be on gluten-containing diets, even if they are causing symptoms, and this is called a "gluten challenge."

• Eat gluten prior to celiac disease blood tests: The amount and length of time can vary, but is somewhere between 2 slices of wheat bread daily for 6-8 weeks and 1/2 slice of wheat bread or 1 wheat cracker for 12 weeks 12 weeks;
• Eat gluten prior to the endoscopic biopsy procedure: 2 slices of wheat bread daily for at least 2 weeks;

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and this recent study recommends 4-6 slices of wheat bread per day: