Biopsy confirmed no celiac, low gliadin igg but high gliadin iga?

[Gliadingoaway]

Biopsy confirmed no celiac but I did have gastritis from h pylori. Gliadin IgG was low but Gliadin IgA was high. Anyone know if this gluten sensitivity is temporary and goes away as I recover from gastritis? I avoided gluten for awhile but wonder if I should go back to gluten over time. I did eat fried wings last week with gluten by accident and felt fine afterwards. Just wondering why gliadin iga is high

[trents]

Welcome to the forum, @Gliadingoaway!

You say you "avoided gluten for awhile". What was the timing of that with regard to when the biopsy and blood draw for the celiac antibody tests were done?

If they coincided, that would explain the negative biopsy results and the mixed results in the blood antibody testing for celiac disease. Any testing for celiac disease is invalidated when a person has been on a gluten free diet leading up to the testing. Those having already embarked on the gluten free diet must restart gluten consumption in generous amounts for weeks/months prior to testing if they wish a valid diagnosis. By generous amounts, I mean at least 10g of gluten daily which is the amount found in about 4-6 slices of wheat bread.

[Scott Adams]

Your situation is intriguing—while the biopsy ruled out celiac disease, the elevated gliadin IgA (along with gastritis from H. pylori) suggests your immune system is reacting to gluten, albeit differently than in classic celiac. High gliadin IgA can occur in non-celiac gluten sensitivity (NCGS), other autoimmune conditions, or even as part of gut inflammation from H. pylori. Since active gastritis can disrupt the intestinal barrier ("leaky gut"), gluten might trigger temporary immune reactions that could calm post-recovery. The fact that you tolerated gluten accidentally doesn’t necessarily rule out sensitivity; symptoms can be delayed or cumulative. To clarify, consider retesting gliadin IgA after fully treating the H. pylori and healing your gut (ask your doctor about timing). If levels normalize, you may cautiously reintroduce gluten. If they stay high, NCGS or another immune trigger (like cross-reactivity with other foods) could be at play. For now, focus on healing the gastritis—your gluten tolerance may improve as your gut does!

[Gliadingoaway]

So i was eating tons of gluten my whole life until two months ago when i had high gliadin iga. At that time, i tested negative ttg and biopsy confirmed no celiac. I had h pylori and severe gastritis (no atrophy or ulcers).

 

fast forward today, i avoided gluten and had antibiotic treatment to erradicate the h pylori. I am feeling much better. A few days ago is when i tested negative for ttg, gliadin igg, endomysial iga. But i did test positive for gliadin iga. Pretty strange because i had gluten three days ago (accidently ate mac and cheese and fried chicken after taking the tests) and i feel fine

[Gliadingoaway]

5 hours ago, Scott Adams said:

Your situation is intriguing—while the biopsy ruled out celiac disease, the elevated gliadin IgA (along with gastritis from H. pylori) suggests your immune system is reacting to gluten, albeit differently than in classic celiac. High gliadin IgA can occur in non-celiac gluten sensitivity (NCGS), other autoimmune conditions, or even as part of gut inflammation from H. pylori. Since active gastritis can disrupt the intestinal barrier ("leaky gut"), gluten might trigger temporary immune reactions that could calm post-recovery. The fact that you tolerated gluten accidentally doesn’t necessarily rule out sensitivity; symptoms can be delayed or cumulative. To clarify, consider retesting gliadin IgA after fully treating the H. pylori and healing your gut (ask your doctor about timing). If levels normalize, you may cautiously reintroduce gluten. If they stay high, NCGS or another immune trigger (like cross-reactivity with other foods) could be at play. For now, focus on healing the gastritis—your gluten tolerance may improve as your gut does!

Thank you!

[Scott Adams]

18 hours ago, Gliadingoaway said:

So i was eating tons of gluten my whole life until two months ago when i had high gliadin iga. At that time, i tested negative ttg and biopsy confirmed no celiac. I had h pylori and severe gastritis (no atrophy or ulcers).

 

fast forward today, i avoided gluten and had antibiotic treatment to erradicate the h pylori. I am feeling much better. A few days ago is when i tested negative for ttg, gliadin igg, endomysial iga. But i did test positive for gliadin iga. Pretty strange because i had gluten three days ago (accidently ate mac and cheese and fried chicken after taking the tests) and i feel fine

This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. According to this article your two positive DGP-IgA tests mean:

Quote

The DGP-IgA test is considered to have high sensitivity and specificity. In general, the DGP-IgA test has been reported to have a sensitivity ranging from 75% to 95% and a specificity ranging from 90% to 100%. Overall, the DGP tests, including DGP-IgA and DGP-IgG, exhibit a sensitivity of approximately 85-95% and a specificity of about 95-98%.