Interpreting Enterolab Results

[Ken70]

I forced my father to get tested through Enterolabs. These are his results. It clearly shows he has gluten and casein sensitivity but does the fecal fat score mean he is probably Celiac?

A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value

Fecal Antigliadin IgA21(Normal Range <10 Units)

Fecal Antitissue Transglutaminase IgA29 Units(Normal Range <10 Units)

Quantitative Microscopic Fecal Fat Score1275 Units(Normal Range <300 Units)

Fecal anti-casein (cow

[ravenwoodglass]

I would say with his other scores yes even if he is not technically gene defined celiac. He is most likely not absorbing much of anything at this point. Hopefully this will turn around quickly once he is gluten and casien free. I would get him on the diet as soon as possible. He also should be taking a good gluten free supplement and an additonal sublingual B12. With a malabsorption score that high I would consider having that rechecked after 3 and again at 6 months to make sure that he is improving.

As you probally already know it is vital that you check every single med he is on, there are no labeling or gluten restrictions for medication. Do not trust the pharmacist, some are great but most have neither the time nor the information available.

[CarlaB]

Not necessarily. There is someone on the board with a high fecal fat score, yet does not have celiac disease nor the gene though she is gluten intolerant.

Bacterial dysbiosis can also cause fat in the stool.

[Ken70]

Not necessarily. There is someone on the board with a high fecal fat score, yet does not have celiac disease nor the gene though she is gluten intolerant.

Bacterial dysbiosis can also cause fat in the stool.

Do you think fish oil pills taken daily could influence these results?

[CarlaB]

No.

[nora-n]

All the tests for gluten sensitivity are positive, and milk too.

Gene test not finished yet.

This is my interpretation.

What are your gene results?

nora

[Ken70]

All the tests for gluten sensitivity are positive, and milk too.

Gene test not finished yet.

This is my interpretation.

What are your gene results?

nora

There are no gene results yet. I dont even know if Enterolab does this. Do we need a seperate blood test for the gene test?

I am having a hard time understanding how something like this can come on to a man in his 60's and not before this. My superfit uncle (fathers brother) died from lung cancer a few years ago. He didn't smoke and took great care of himself.

I am undiagnosed and that is the way I am going to stay. I have been gluten free for 6 months and casein free for 2 months. Huge difference but not all the way there yet.

[mftnchn]

Do you think fish oil pills taken daily could influence these results?

Enterolab instructions say to avoid taking these three days before the test. I did this, and when my malabsorption was sky high, asked my allergist about it. He said that even if my body is slow to process and empty (hence my question did I still have these in my system?, taking these would not be enough to cause the malabsorption to be so high.

But yes there are many causes of malabsorption, so that is not diagnostic for celiac. Only the positive test panel together is suggestive.

[ravenwoodglass]

There are no gene results yet. I dont even know if Enterolab does this. Do we need a seperate blood test for the gene test?

I am having a hard time understanding how something like this can come on to a man in his 60's and not before this. My superfit uncle (fathers brother) died from lung cancer a few years ago. He didn't smoke and took great care of himself.

I am undiagnosed and that is the way I am going to stay. I have been gluten free for 6 months and casein free for 2 months. Huge difference but not all the way there yet.

If you had ordered the gene test they would have sent you a cheek swab to do it with. I don't remember how much it is, I think it was around $100. I just ordered mine out of curiosity 4 years after I was diagnosed and because my DD had her genes done and used that as a way to say 'see I don't have celiac and will never develop it because I don't have the gene'. I am proof positive that non celiac gene defined celiac can be just as life threatening and altering as any with the celiac genes.

As to how this could show up in someone who is 60, well he most likely had indications of it for years that he may have assumed were normal bouts of illness. Celiac also has a way of excaberating when when are ill or under stress. Many women will develop noticable symptoms after preganacy and for both sexes mental or physical stress can trigger it.

[Ken70]

Final Results are in for Enterolab gene test. Do you concur that my father should stop eating gluten and casein? I did an elimination diet to diagnose myself and I am now gluten and casein free. It has made a big difference but I am still strugling with the occasion glutening.

A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value

Fecal Antigliadin IgA 21 (Normal Range <10 Units)

Fecal Antitissue Transglutaminase IgA 29 Units (Normal Range <10 Units)

Quantitative Microscopic Fecal Fat Score 1275 Units (Normal Range <300 Units)

Fecal anti-casein (cow's milk) IgA antibody 15 Units (Normal Range <10 Units)

HLA-DQB1 Molecular analysis, Allele 1 0301

HLA-DQB1 Molecular analysis, Allele 2 0501

Serologic equivalent: HLA-DQ 3,1 (Subtype 7,5)

Interpretation of Fecal Antigliadin IgA: Intestinal antigliadin IgA antibody was elevated, indicating that you have active dietary gluten sensitivity. For optimal health, resolution of symptoms (if you have them), and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well.

Interpretation of Fecal Antitissue Tra! nsglutam inase IgA: You have an autoimmune reaction to the human enzyme tissue transglutaminase, secondary to dietary gluten sensitivity.

Interpretation of Quantitative Microscopic Fecal Fat Score: A fecal fat score greater than or equal to 300 Units indicates there is an increased amount of dietary fat in the stool which usually is due to gluten-induced small intestinal malabsorption/damage when associated with gluten sensitivity. Values between 300-600 Units are mild elevations, 600-1000 Units moderate elevations, and values greater than 1000 Units are severe elevations. Any elevated fecal fat value should be rechecked in one year after treatment to ensure that it does not persist because chronic fat malabsorption is associated with osteoporosis among other nutritional deficiency syndromes.

Interpretation of Fecal anti-casein (cow's milk) IgA antibody: Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic "sensitivity" to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.

Interpretation Of HLA-DQ Testing: Although you do not possess the main genes predisposing to celiac sprue (HLA-DQ2 or HLA-DQ8), HLA gene analysis reveals that you have two copies of a gene that pr! edispose s to gluten sensitivity (DQ1 or DQ3 not subtype 8). Having two copies of a gluten sensitive gene, means that each of your parents, and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity may be more severe.

[confused]

I have the aame genes as ur father, and am diagnosed celiac threw blood work and confirmed Dh. Your father should give up gluten and casein as soon as he can.

paula

[nora-n]

DQ7 and DQ5:

Now DQ7 is very similar to DQ8, a main celiac gene. There is an article on DQ7 and celiac here:

Open Original Shared Link and they found some celiacs who were DQ7.

DQ5 is a subtype of DQ1 and several people on the forums with neurological symptoms report they are DQ1 or double DQ1.

Dr. Hadjivassiliou writes in several papers that about 20% of his gluten ataxia subjects are DQ1.

"we have found a similar HLA association to that seen in patients with celiac disease: 70% of patients have the HLA DQ2 (30% in the general population), 9% have the HLA DQ8, and the remainder have HLA DQ1. The finding of an additional HLA marker (DQ1) seen in the remaining 20% of our patients may represent an important difference between the genetic susceptibility of patients with neurological presentation to those with gastrointestinal presentation within the range of gluten sensitivity.

" See also other papers by Hadjivassiliou (like in www.pubmed.com)

nora