Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Genes -- Are You Cd Positive?

Professor

Recommended Posts

Professor Rookie
Professor
Posted

I was just reading the HLA types that are responsible for celiac disease, and then dug mine (printout of my genes) out of my file drawer (I have them because I was tested for a bone marrow transplant). They listed several HLA types on the site I was reading, and say that almost everyone with celiac disease has one of those in the first group, but the few that don't almost always have this other one. Be darned if I don't have both -- one in the first group, and also the one that is the "back-up!" :o Unbelievable, huh? Guess I was just bound to get celiac disease.

So I was wondering how many also have the gene that causes celiac disease, or if you were tested?

Patty

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


KaitiUSA Enthusiast
KaitiUSA
Posted

Yep I have the celiac disease gene. That's one thing they tested me for in the blood test I had done

celiac3270 Collaborator
celiac3270
Posted

Me, too

mommida Enthusiast
mommida
Posted

My daughter has 2 genes for Celiac. DQ2 and Dq8.

red345 Apprentice
red345
Posted

If you're referring to the DQ2 and DQ8, mine were negative, though I am a Type 1 Diabetic. That was also the case for my family member, whose blood and biopsies at one time read positive for Celiac. And that is exactly why I've never bought into this, at least in her case.

Professor Rookie
Professor
Posted
  • Author
If you're referring to the DQ2 and DQ8 . . .

Well, I guess that must be an abbreviated description -- sorry I don't know it as such. The full typing assays, and my own molecular diagnostics reports list them fully:

"The majority of celiac disease patients carry the DRB1*0301- DQA1*0501- DQB1*0201 haplotype (the DR3, DQ2 haplotype) or are DRB1*11/12-DQA1*0505- DQB1*0301/ DRB1*07- DQA1*0201- DQB1*0202 heterozygotes (carry the DR5-DQ7/DR7-DQ2 haplotypes). Almost all the celiac patients who are DQA1*05 and DB1*02 negative bear the DRB1*04, DQA1*0301, DQB1*0302 haplotype (i.e., DR4-DQ8 )."

So, unfortunately I can only answer your question with another question: are we referring to the same thing? I think so. :unsure: But thanks for replying.

Patty

(Citation:

Open Original Shared Link )

Maggie1956 Rookie
Maggie1956
Posted

:huh: Umm...well my blood test came back positive. So did my biopsy. <_< Is that what you mean? I'm really quite uneducated, when it comes to all the medical terms.

Cheers :)

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


MySuicidalTurtle Enthusiast
MySuicidalTurtle
Posted

I don't know but I think I would since my Mother and brother both have Celiacs.

red345 Apprentice
red345
Posted

Excellent question, professor. I'll take another look into this. I know that there has been some confusion along the way in her case. Her medical reports detail testing for the DQ2 and DQ8, both of which were negative. I can say for certain that these tests also are defined in my medical history. I did research this at one time and the lab titles seemed to go along with what I was reading, but I will try to go back and take another look here at some point.

I must compliment you for the type of investigation you are attempting here. Great work.

burdee Enthusiast
burdee
Posted

My Enterolab test results (back in 7/04) indicated that I "have a copy of one of the main genes that predisposes to gluten sensitivity and celiac sprue, HLA-DQ3, subtype 8 (HLA-DQ8). This genotype also can predispose to microscopic colitis and other autoimmune syndromes".

BURDEE

KaitiUSA Enthusiast
KaitiUSA
Posted

I have the HLA-DQ2 gene. Does anybody know if this gene comes from both parents?

gf4life Enthusiast
gf4life
Posted

It can come from either parent or from both if you have two copies or one of each.

My daughter and I both have one copy of DQ2. My boys don't have either but are still gluten intolerant. They both have DQ3, subtype 7. DQ3, subtype 8 is the one referred to as DQ8. I am still wondering if they have missed the fact that other subtypes of DQ3 can cause problems with gluten. I have all of the children on the gluten-free diet, since they all responded so well to the diet. Almost all of their health problems went away and their growth has been amazing.

God bless,

Mariann

KaitiUSA Enthusiast
KaitiUSA
Posted

Thanks:) If I have 2 copies of the gene that would mean it came from both parents correct?

Also, when I was tested for the gene would they have told me if there was more than one copy of the gene in the results?

We are trying to figure out which side it came frome it seems both sides of the family think it is the other side that has the gene and they aren't being to easy about getting tested <_<

Thank you all for your help :D

gf4life Enthusiast
gf4life
Posted
Also, when I was tested for the gene would they have told me if there was more than one copy of the gene in the results?

They would not necessarily tell you if you had more than one copy. They would only be required to tell you if you were positive for the gene or not. It would be a good idea for your parents to be tested, regardless of if there are two copies of the gene, or if they have symptoms. But I do understand about them not being easy about getting tested. My husband won't be tested, and my father is convinced that it isn't an issue. I have 6 siblings and only one has tried to be tested, and her doctor is clueless as to what tests to order. My sister decided to let it go for now, since she doesn't plan on following the gluten-free diet anyhow!

God bless,

Mariann

KaitiUSA Enthusiast
KaitiUSA
Posted

gf4life-Thank you so much. That info definately helps out so much. My parents have both been tested. Digestive problems run in the family on both sides and we suspect possibly some cousins ,grandma, and others that may have celiac. They aren't necessarily convinced either and it's hard because we can only tell them so much and give them so much info. I guess when their symptoms get bad enough they will be tested. Again thanks and God bless! :D

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. xxnonamexx
      - xxnonamexx replied to xxnonamexx's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      32

      My journey is it gluten or fiber?

      I made it through the holiday w/o being glutened. I had my brother cook with gluten-free breadcrumbs and I didn't get sick. I baked cookies with gluten-free flour and had dry ingredients for cookies in ziplock bag. I also made gluten cookies as well and guess I did good washing to avoid CC. My wife also went to a french bakery and bought a gluten-free flourless...
    2. xxnonamexx
      - xxnonamexx replied to xxnonamexx's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      32

      My journey is it gluten or fiber?

      What do you mean it would not allow any celiac to eat gluten again. I think if this helps cross contamination when eating out at a non dedicated gluten-free restaurant this would be nice not to encounter the pains. But is their a daily enzyme to take to help strengthen the digestive system?
    3. SamAlvi
      - SamAlvi replied to SamAlvi's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      2

      High TTG-IgG and Normal TTG-IgA

      Hi, thank you for the reply. Unfortunately, no other antibody tests were ordered. I am a 32-year-old male. About two months ago, I ate pancakes and then developed severe diarrhea that lasted the entire day. At night, I became unconscious due to fluid loss and was admitted to the ER, where I received IV fluids. Two days later, I ate bread again and once...
    4. trents
      - trents replied to SamAlvi's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      2

      High TTG-IgG and Normal TTG-IgA

      Welcome to the celiac.com community, @SamAlvi! Were there any other antibody tests ordered? Particularly, was there a "total IGA" test ordered to check for IGA deficiency. When people are IGA deficient, celiac panel IGA test scores, such as the TTG-IGA, are likely not valid. If a total IGA test was not ordered, I would request such to be done. Note:...
    5. Scott Adams
      0

      Homemade Gluten-Free Egg Drop Soup

  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      132,844
    • Most Online (within 30 mins)
      7,748
    donnawebb265
    Newest Member
    donnawebb265
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • xxnonamexx
      My journey is it gluten or fiber?

      By xxnonamexx · Posted

      I made it through the holiday w/o being glutened. I had my brother cook with gluten-free breadcrumbs and I didn't get sick. I baked cookies with gluten-free flour and had dry ingredients for cookies in ziplock bag. I also made gluten cookies as well and guess I did good washing to avoid CC. My wife also went to a french bakery and bought a gluten-free flourless chocolate cake dedicated gluten-free it was out of this world. 
    • xxnonamexx
      My journey is it gluten or fiber?

      By xxnonamexx · Posted

      What do you mean it would not allow any celiac to eat gluten again. I think if this helps cross contamination when eating out at a non dedicated gluten-free restaurant this would be nice not to encounter the pains. But is their a daily enzyme to take to help strengthen the digestive system? 
    • SamAlvi
      High TTG-IgG and Normal TTG-IgA

      By SamAlvi · Posted

      Hi, thank you for the reply. Unfortunately, no other antibody tests were ordered. I am a 32-year-old male. About two months ago, I ate pancakes and then developed severe diarrhea that lasted the entire day. At night, I became unconscious due to fluid loss and was admitted to the ER, where I received IV fluids. Two days later, I ate bread again and once more developed severe diarrhea. I ended up in the ER again and received IV fluids. In my country, Pakistan, doctors are unfortunately not very thorough, so they treated me for a stomach infection. I visited three or four doctors, including a gastroenterologist, but it seemed like they just wanted to keep me on medications and IV fluids. Eventually, I did some digging myself and started connecting the dots. For years, I’ve had excessive gas buildup and frequent loose stools, but I never paid much attention to it. I also cannot easily digest dairy products. Two years ago, I had a CBC test that showed iron deficiency. My doctor told me to eat more meat and said it was nothing serious. However, for the past five years, I’ve also had severe motion sickness, which I never experienced before. Whenever I get on a bus or in a car, I sometimes lose consciousness for 10–20 seconds and wake up sweaty, and occasionally I feel the need to vomit. After more research on the internet, I came across gluten and celiac disease, so I got two related tests (TTG-IgA & TTG IgG) done along with a stool test and another CBC. The stool test showed weakly positive blood. Ever since eating those pancakes and bread, I’ve had a burning sensation in my gut. My doctor reviewed my tests, he told me to completely stop eating gluten and started me on IV fluids for 20 days, saying that I had severe inflammation in my gut. It has now been two months since I quit gluten, and I’m still not sure whether this is celiac disease or gluten intolerance. I don’t really trust doctors in Pakistan, so I thought I might get some help here.
    • trents
      High TTG-IgG and Normal TTG-IgA

      By trents · Posted

      Welcome to the celiac.com community, @SamAlvi! Were there any other antibody tests ordered? Particularly, was there a "total IGA" test ordered to check for IGA deficiency. When people are IGA deficient, celiac panel IGA test scores, such as the TTG-IGA, are likely not valid. If a total IGA test was not ordered, I would request such to be done. Note: "Total IGA" goes by other names as well. I will include a primer on celiac disease antibody testing which does a good job in covering the nomenclature variations connected with the various tests. Elevated IGG scores can certainly indicate celiac disease but they are more likely than elevated IGA tests to be caused by something else.  
    • GlorietaKaro
      Am I nuts?

      By GlorietaKaro · Posted

      Thank you— yes, valid and essential— The issue either doctors is that every one I have tried to talk to about this has essentially rolled their eyes and dismissed me as a hypochondriac, which gets discouraging. I believe a diagnosis would help me to be taken seriously by doctors as well as being validating, but can carry on without it.    There are many, probably most people in my area of my age and gender, who avoid gluten, but many just avoid it casually— eating the occasional plate of wheat pasta or a delicious-looking dessert, or baking cookies with wheat flour for gatherings.  That is not an option for me. I don’t eat other people’s cooking or go to restaurants that do not have strict cross- contamination procedures. It can be boring and lonely, and people do look at me as if I am being a bit dramatic but weeks of symptoms after a single small exposure has taught me to respect my experience.    Thank you very much for your response— sometimes I just need to hear that I am not crazy—
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.