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- Scott Adams replied to Lotte18's topic in Publications & Publicity5Prospective CRISPR research
The HLA-DQ2 and HLA-DQ8 genes are part of the immune system’s antigen-presentation system—they help immune cells recognize and respond to foreign proteins like bacteria or viruses. In people with celiac disease, those same molecules happen to bind certain gluten fragments very effectively and present them to T-cells, which can trigger the autoimmune reaction in ... -
- Aretaeus Cappadocia replied to jenniber's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms16Disaccharide deficient, confusing biopsy results, no blood test
If you or your brother have children, they should be informed about all of this because they would have an increased risk for celiac themselves. I imagine you would have told your children (if you have any) but your brother might be inclined to dismiss it. -
- Scott Adams commented on Scott Adams's blog entry in Gluten Busters: Gluten-Free Product Alerts by Celiac.com10
Simple Mills and Made Good Foods Products May Contain Gluten Levels Above the FDA's Allowable Limit of 20 ppm
I don't want to boost their link, but if you wish to go down that rabbit hole here are some old comments on our articles: https://www.celiac.com/celiac-disease/are-gluten-free-cheerios-really-unsafe-for-celiacs-r3903/page/6/?tab=comments#comment-18332 -
- trents replied to Ben Cohen's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms7How much gluten do I need to eat prior to testing?
@Ben Cohen, make sure you ask your physician to order a test called "Immunoglobulin A (IgA)" (aka, "total IGA"), which tests for IGA deficiency, along with the tTG-IgA. The tTG-IgA is the primary test used these days to check for celiac disease but if you are IGA deficient, the tTG-IgA will not be accurate. Some physicians neglect to check for IGA deficiency...- 1
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- Dr. Gunn replied to Ben Cohen's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms7How much gluten do I need to eat prior to testing?
Before putting yourself through the disruption of a gluten challenge, you might want to check and see if you carry the celiac risk genes DQ2 and/or DQ8. If you don't carry the genes your celiac disease risk is below 1%. If you do have the genes, a gluten challenge followed by antibody testing would be the next steps for a proper medical diagnosis.- 1
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By Scott Adams · Posted
The HLA-DQ2 and HLA-DQ8 genes are part of the immune system’s antigen-presentation system—they help immune cells recognize and respond to foreign proteins like bacteria or viruses. In people with celiac disease, those same molecules happen to bind certain gluten fragments very effectively and present them to T-cells, which can trigger the autoimmune reaction in the small intestine. There’s quite a bit of immunology research on how these HLAs function generally, and much of the current celiac research focuses on interrupting that specific gluten-presentation pathway rather than altering the genes themselves. Regarding the wheat issue, you’re right that supply chain separation would still matter. Even if gene-edited wheat produced fewer or less immunogenic gluten proteins, it would still need careful handling to avoid mixing with conventional wheat. The main advantage researchers are exploring is reducing the specific gluten peptides that trigger celiac immune reactions, which could potentially make wheat safer at the biological level. But even if such wheat proves helpful, it probably wouldn’t eliminate the need for gluten-free production controls or kitchen cross-contamination precautions. -
By Aretaeus Cappadocia · Posted
If you or your brother have children, they should be informed about all of this because they would have an increased risk for celiac themselves. I imagine you would have told your children (if you have any) but your brother might be inclined to dismiss it. -
@Ben Cohen, make sure you ask your physician to order a test called "Immunoglobulin A (IgA)" (aka, "total IGA"), which tests for IGA deficiency, along with the tTG-IgA. The tTG-IgA is the primary test used these days to check for celiac disease but if you are IGA deficient, the tTG-IgA will not be accurate. Some physicians neglect to check for IGA deficiency, operating on the outdated assumption that it only occurs in young children. Here is an article outlining the various antibody tests that can be ordered to detect celiac disease: Another thing to keep in mind is that, as Dr. Gunn indicated, if the antibody testing is positive, your physician will likely want to confirm those results with a biopsy which would require you to remain on the gluten challenge.
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Before putting yourself through the disruption of a gluten challenge, you might want to check and see if you carry the celiac risk genes DQ2 and/or DQ8. If you don't carry the genes your celiac disease risk is below 1%. If you do have the genes, a gluten challenge followed by antibody testing would be the next steps for a proper medical diagnosis.
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Typical, I suppose.
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