Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Gene Test Results Negative

gatita

Recommended Posts

gatita Enthusiast
gatita
Posted

Here are my gene test results, so it seems it is NOT celiac. Which is good news for my relatives. :) I guess this narrows what I have down to NCGI, but my GI doc is doing an endo in a couple weeks anyway....

I'm not doubting the interpretation, but can anyone decipher what this means? I get what the first two are and am lost after that.

---------------------------------

Interpretation --- The patient does not have the HLA-DQ variants associated with celiac disease.

More than 97% of celiac patients carry either HLA-DQ2(DQA1*05/DQB1*02) or HLA-DQ8(DQA1*03/DQB1*0302) or both.

Hla-Dq2 Negative

Hla-Dq8 Negative

Hla-Dqa1 -- 01

Hla-Dqa1 -- 02

Hla-Dqb1 -- 0303

Hla-Dqb1 -- 0603

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


kareng Grand Master
kareng
Posted

Unless you are in the 3% that don't have the genes they test for?

gatita Enthusiast
gatita
Posted
  • Author

Oh.... I didn't think of that. Maybe that's why he's doing the scope anyway. <_<

Celiac Mindwarp Community Regular
Celiac Mindwarp
Posted

I was told if I don't have the genes, I ain't celiac (I don't have the genes). Does anyone have any information about the other 3%?

mushroom Proficient
mushroom
Posted

I was told if I don't have the genes, I ain't celiac (I don't have the genes). Does anyone have any information about the other 3%?

ravenwoodglass belongs in that 3%. You can find out what it did to her :wacko:

gatita Enthusiast
gatita
Posted
  • Author

So my GI seems to be sure I am celiac negative, given my blood tests were also neg. I'm at a loss as to why he's doing the endo, plus I'm supposed to start a gluten challenge on Sunday. Why would I do a gluten challenge and biopsy if he is convinced I'm negative anyway?

I tend to think that I'm probably not in that "less than 3 percent" group -- I mean those are pretty slim odds. I have to accept that all of the most sophisticated tests say I'm not celiac. I guess the biopsy will be the last test.

I'm kind of freaking out about what to do next because I still can't eat gluten and I seem to have a wheat allergy, as in the puffy face and all. So little is known about NCGI... Are all the potential complications the same? Do I need to be as strict? I don't mind being gluten-strict in my own home, but I do sometimes feel bad giving friends and family the once-over in their own kitchens. Can I lay off them a little if I don't have celiac?? :(

----

Also, does anybody know what the last four gene tests mean, if anything?

Hla-Dqa1 -- 01

Hla-Dqa1 -- 02

Hla-Dqb1 -- 0303

Hla-Dqb1 -- 0603

gatita Enthusiast
gatita
Posted
  • Author

OK answering some of my own questions here :) . It looks like the Hla-Dqb1 -- 0303 is the same as DQ9? Is that right? And DQ9 is now possibly linked to a "pre-disposure" to celiac and/or gluten intolerance:

Open Original Shared Link

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Ninja Contributor
Ninja
Posted

Actually, I've read studies wherein they've found up to 6-8% (I think) being negative for both the alpha and beta chains of DQ2 and DQ8 (which includes, by default, DQ7.5), the study had a very large cohort as well. Let me see if I can dig it up...

EDIT: Here are a couple I've read a long the way.... still digging for the study that showed only 93% of the celiac cohort showed DQ2 and/or DQ8.

Open Original Shared Link

Open Original Shared Link

Open Original Shared Link - In this article Dr. Fasano acknowledges that 2-3% of people diagnosed with Celiac do not have the genes.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      132,589
    • Most Online (within 30 mins)
      7,748
    GigiConnie
    Newest Member
    GigiConnie
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • amantelchi
      Stomach hurts with movement

      By amantelchi · Posted

      I'd like to clarify: Is the pain you describe in the area just below your chest constant, or does it only appear when you start moving?
    • Jmartes71
      Shingles - Could It Be Related to Gluten/ Celiac

      By Jmartes71 · Posted

      Shingles is dormant and related to chicken pox when one has had in the past.Shingles comes out when stress is heightened.I had my 3rd Shingles in 2023.
    • knitty kitty
      Shingles - Could It Be Related to Gluten/ Celiac

      By knitty kitty · Posted

      Here's one more that shows Lysine also helps alleviate pain! Exploring the Analgesic Potential of L-Lysine: Molecular Mechanisms, Preclinical Evidence, and Implications for Pharmaceutical Pain Therapy https://pmc.ncbi.nlm.nih.gov/articles/PMC12114920/
    • Flash1970
      Shingles - Could It Be Related to Gluten/ Celiac

      By Flash1970 · Posted

      Thank you for the links to the articles.  Interesting reading. I'll be telling my brother in law because he has a lot of pain
    • Scott Adams
      gluten-free Oatmeal

      By Scott Adams · Posted

      Oats naturally contain a protein called avenin, which is similar to the gluten proteins found in wheat, barley, and rye. While avenin is generally considered safe for most people with celiac disease, some individuals, around 5-10% of celiacs, may also have sensitivity to avenin, leading to symptoms similar to gluten exposure. You may fall into this category, and eliminating them is the best way to figure this out. Some people substitute gluten-free quinoa flakes for oats if they want a hot cereal substitute. If you are interested in summaries of scientific publications on the topic of oats and celiac disease, we have an entire category dedicated to it which is here: https://www.celiac.com/celiac-disease/oats-and-celiac-disease-are-they-gluten-free/   
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.