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    Jefferson Adams
    Jefferson Adams

    By Jefferson Adams •

    Bio-physical Characteristics of Gastrointestinal Mucosa of Celiac Patients: Comparison with Control Subjects and Effect of Gluten-Free Diet

    Reviewed and edited by a celiac disease expert.
    Bio-physical Characteristics of Gastrointestinal Mucosa of Celiac Patients: Comparison with Control Subjects and Effect of Gluten-Free Diet - Photo: CC -- spec-ta-cles
    Caption: Photo: CC -- spec-ta-cles

    Celiac.com 11/28/2011 - Celiac disease often results in "leaky" intestinal mucosa. This development may involve changes in hydrophobicity of the mucus surface barrier along with changes of the epithelial barrier.

    A team of researchers recently compared bio-physical aspects of gastrointestinal mucosa of celiac patients with control subjects, along with the effects of gluten free diet on each group.

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    Photo: CC -- spec-ta-clesThe research team included Stefania Bertolazzi, Francesco Lanzarotto, Barbara Zanini, Chiara Ricci, Vincenzo Villanacci, and Alberto Lanzini.

    The team set out to compare duodenal hydrophobicity as an index of mucus barrier integrity in 38 patients studied before and 68 patients during gluten-free diet, and in 90 control subjects. They also checked for regional differences of hydrophobicity in the gastro-intestinal tract.

    The team gauged hydrophobicity by measuring the contact angle (CA) (Rame Hart 100/10 goniometer) created by a single drop of water applied to intestinal mucosal biopsies.

    Once the team pooled the results and evaluated the control groups, patients with histologically normal duodenal biopsies showed significantly higher CA (620 + 90)  than patients with biopsies showing Marsh 1-2 (580 + 100; p<0.02) and Marsh 3 lesions (570+ 100; p<0.02).

    Among the control group, the action sequence of hydrofobicity along the gastrointestinal tract follows the pattern: gastric antrum> corpus> rectum> duodenum> oesophagus> ileum.

    From these results, the team concludes that people with celiac disease experience reduced hydrophobicity of duodenal mucous layer, and a reduced ability to repel luminal contents. This may may contribute to the increased intestinal permeability seen in celiac disease.

    This change in hydrofobicity corresponds to the severity of the mucosal lesions in the patient, and is not completely reversed by gluten-free diet.

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    Guest Allen G. Reiter

    Guest Allen G. Reiter

    Posted

    It would be helpful for this article to be written in layman's terms. I doubt that most readers will understand its point.

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    Guest dot

    I get it, but what do I do about it?

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    Guest Laurie Massey

    Guest Laurie Massey

    Posted

    I get it, but what do I do about it?

    My sentiments exactly!!! What are we to do about permeability and malabsorption issues???

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    Guest Jane

    I agree. Layman's terms. Had to look up a number of words.....takes a great deal of time in this busy world.

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    Guest Gloria Brown

    Guest Gloria Brown

    Posted

    For celiacs gluten can irreversibly damage the intestinal lining, so that its contents "leak" into the rest of the body, a set-up for eventual major disease. At the moment, eating fresh food only and keeping one's environment gluten-free, are one's best defense.

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    Guest Robena

    I totally agree with Dot. I get it because I live with it, but how do I get rid of it?

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    Guest Suzanne

    Guest Suzanne

    Posted

    I understand that they are saying that we who are gluten-intolerant are not able to form a protective layer to keep the contents of our intestines inside (so some leaks out into the bloodstream). What do they mean, however, by that not being resolved by a gluten-free diet? Never? Do we always have a leaky gut? (I have heard that another gut gate-keeper that allows permeability, called Zonulin, also remains elevated in celiac disease--sounds like we're doomed!)

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    Guest admin
    I agree. Layman's terms. Had to look up a number of words.....takes a great deal of time in this busy world.

    We do our best to update our glossary...note that you can click on many of the terms to get a definition.

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    Guest lAURA
    It would be helpful for this article to be written in layman's terms. I doubt that most readers will understand its point.

    I agree. What the heck is it telling us?

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  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     

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